William Middleton

2025

Does surgical intervention alter the natural history of degenerative rotator cuff tears? Comparative analysis from a prospective longitudinal study

Hill, J. R., Olson, J. J., Sefko, J. A., Steger-May, K., Teefey, S. A., Middleton, W. D. & Keener, J. D., Feb 2025, In: Journal of Shoulder and Elbow Surgery. 34, 2, p. 430-440 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2024

CD4⁺ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans

Borcherding, N., Kim, W., Quinn, M., Han, F., Zhou, J. Q., Sturtz, A. J., Schmitz, A. J., Lei, T., Schattgen, S. A., Klebert, M. K., Suessen, T., Middleton, W. D., Goss, C. W., Liu, C., Crawford, J. C., Thomas, P. G., Teefey, S. A., Presti, R. M., O’Halloran, J. A. & Turner, J. S. & 2 others, Ellebedy, A. H. & Mudd, P. A., Sep 2024, In: Nature immunology. 25, 9, p. 1731-1741 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Influenza vaccination stimulates maturation of the human T follicular helper cell response

Schattgen, S. A., Turner, J. S., Ghonim, M. A., Crawford, J. C., Schmitz, A. J., Kim, H., Zhou, J. Q., Awad, W., Mettelman, R. C., Kim, W., McIntire, K. M., Haile, A., Klebert, M. K., Suessen, T., Middleton, W. D., Teefey, S. A., Presti, R. M., Ellebedy, A. H. & Thomas, P. G., Sep 2024, In: Nature immunology. 25, 9, p. 1742-1753 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Maturation of germinal center B cells after influenza virus vaccination in humans

McIntire, K. M., Meng, H., Lin, T. H., Kim, W., Moore, N. E., Han, J., McMahon, M., Wang, M., Malladi, S. K., Mohammed, B. M., Zhou, J. Q., Schmitz, A. J., Hoehn, K. B., Carreño, J. M., Yellin, T., Suessen, T., Middleton, W. D., Teefey, S. A., Presti, R. M. & Krammer, F. & 5 others, Turner, J. S., Ward, A. B., Wilson, I. A., Kleinstein, S. H. & Ellebedy, A. H., Aug 5 2024, In: Journal of Experimental Medicine. 221, 8, e20240668.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Predictors of pain development for contralateral asymptomatic degenerative rotator cuff tears based on features of an ipsilateral painful cuff tear: a prospective longitudinal cohort study

Olson, J. J., Hill, J. R., Wang, J., Sefko, J. A., Teefey, S. A., Middleton, W. D. & Keener, J. D., Feb 2024, In: Journal of Shoulder and Elbow Surgery. 33, 2, p. 234-246 13 p.

Research output: Contribution to journal › Article › peer-review

2023

Characterization of adnexal lesions using photoacoustic imaging to improve sonographic O-RADS risk assessment

Zhu, Q., Luo, H., Middleton, W. D., Itani, M., Hagemann, I. S., Hagemann, A. R., Hoegger, M. J., Thaker, P. H., Kuroki, L. M., MCourt, C. K., Mutch, D. G., Powell, M. A. & Siegel, C. L., Dec 2023, In: Ultrasound in Obstetrics and Gynecology. 62, 6, p. 891-903 13 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Contrast-Enhanced Ultrasound for Image-Guided Procedures

Russell, G., Strnad, B. S., Ludwig, D. R., Middleton, W. D., Itani, M., Khot, R., Mellnick, V. & Malone, C., Sep 2023, In: Techniques in vascular and interventional radiology. 26, 3, 100913.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Evaluation of survivorship of asymptomatic degenerative rotator cuff tears in patients 65 years and younger: a prospective analysis with long-term follow-up

Torchia, M. T., Sefko, J. A., Steger-May, K., Teefey, S. A., Middleton, W. D. & Keener, J. D., Jul 2023, In: Journal of Shoulder and Elbow Surgery. 32, 7, p. 1432-1444 13 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Improving the Efficacy of ACR TI-RADS Through Deep Learning-Based Descriptor Augmentation

Barinov, L., Jairaj, A., Middleton, W. D., Beland, Kirsch, J., Filice, R. W., Reverter, J. L., Arguelles, I. & Grant, E. G., Dec 2023, In: Journal of Digital Imaging. 36, 6, p. 2392-2401 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Persons with HIV Develop Spike-Specific Lymph Node Germinal Center Responses following SARS-CoV-2 Vaccination

Quinn, M., Parra-Rodriguez, L., Alsoussi, W. B., Ayres, C., Klebert, M. K., Liu, C., Suessen, T., Scheaffer, S. M., Middleton, W. D., Teefey, S. A., Powderly, W. G., Diamond, M. S., Presti, R. M., Ellebedy, A. H., Turner, J. S., O’Halloran, J. A. & Mudd, P. A., Apr 1 2023, In: Journal of Immunology. 210, 7, p. 947-958 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

Alsoussi, W. B., Malladi, S. K., Zhou, J. Q., Liu, Z., Ying, B., Kim, W., Schmitz, A. J., Lei, T., Horvath, S. C., Sturtz, A. J., McIntire, K. M., Evavold, B., Han, F., Scheaffer, S. M., Fox, I. F., Mirza, S. F., Parra-Rodriguez, L., Nachbagauer, R., Nestorova, B. & Chalkias, S. & 13 others, Farnsworth, C. W., Klebert, M. K., Pusic, I., Strnad, B. S., Middleton, W. D., Teefey, S. A., Whelan, S. P. J., Diamond, M. S., Paris, R., O’Halloran, J. A., Presti, R. M., Turner, J. S. & Ellebedy, A. H., May 18 2023, In: Nature. 617, 7961, p. 592-598 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

2022

Analysis and Classification of Postcatheterization Femoral Arteriovenous Fistulas Based on Color Doppler Examinations

Middleton, W. D. & Robinson, K. A., Jan 2022, In: Journal of Ultrasound in Medicine. 41, 1, p. 207-216 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Detection and management of bleeding in the setting of image-guided percutaneous needle biopsy

Strnad, B. S., Itani, M. & Middleton, W. D., Aug 2022, In: Abdominal Radiology. 47, 8, p. 2681-2696 16 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Germinal centre-driven maturation of B cell response to mRNA vaccination

Kim, W., Zhou, J. Q., Horvath, S. C., Schmitz, A. J., Sturtz, A. J., Lei, T., Liu, Z., Kalaidina, E., Thapa, M., Alsoussi, W. B., Haile, A., Klebert, M. K., Suessen, T., Parra-Rodriguez, L., Mudd, P. A., Whelan, S. P. J., Middleton, W. D., Teefey, S. A., Pusic, I. & O’Halloran, J. A. & 3 others, Presti, R. M., Turner, J. S. & Ellebedy, A. H., Apr 7 2022, In: Nature. 604, 7904, p. 141-145 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

207 Scopus citations

Management of Incidentally Detected Gallbladder Polyps: Society of Radiologists in Ultrasound Consensus Conference Recommendations

Kamaya, A., Fung, C., Szpakowski, J. L., Fetzer, D. T., Walsh, A. J., Alimi, Y., Bingham, D. B., Corwin, M. T., Dahiya, N., Gabriel, H., Park, W. G., Porembka, M. R., Rodgers, S. K., Tublin, M. E., Yuan, X., Zhang, Y. & Middleton, W. D., Nov 2022, In: Radiology. 305, 2, p. 277-289 13 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Optimization of Patient Positioning for the Sonographic Evaluation of Gallstone Impaction: Analysis of Gallbladder Orientation Based on Computed Tomography

Zulfiqar, M., Calhoun, B., Shetty, A., Jyoti, A. & Middleton, W., Dec 1 2022, In: Ultrasound Quarterly. 38, 4, p. 341-345 5 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

SARS-CoV-2 mRNA Vaccination Causes Prolonged Increased Cortical Thickening and Vascularity in Ipsilateral Axillary Lymph Nodes

Teefey, S. A., Middleton, W. D., Turner, J. S., Ellebedy, A. H., Suessen, T., Wallendorf, M., O'Halloran, J. A. & Presti, R., Nov 2022, In: Journal of Ultrasound in Medicine. 41, 11, p. 2849-2858 10 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

SJTRC Study Team, Feb 17 2022, In: Cell. 185, 4, p. 603-613.e15

Research output: Contribution to journal › Article › peer-review

Open Access

191 Scopus citations

Survey Study on the Experience, Practice Patterns, and Preferences of the Fellows of the Society of Radiologists in Ultrasound for Evaluation and Management of Gallbladder Polyps Detected With Ultrasound

Middleton, W. D., Fung, C., Dahiya, N., Szpakowski, J. L., Corwin, M. T., Fetzer, D. T., Gabriel, H., Rodgers, S. K., Tublin, M. E., Walsh, A. J. & Kamaya, A., Jun 1 2022, In: Ultrasound Quarterly. 38, 2, p. 96-102 7 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Ultrasonography of Superficial Soft-Tissue Masses: Society of Radiologists in Ultrasound Consensus Conference Statement

Jacobson, J. A., Middleton, W. D., Allison, S. J., Dahiya, N., Lee, K. S., Levine, B. D., Lucas, D. R., Murphey, M. D., Nazarian, L. N., Siegel, G. W. & Wagner, J. M., Jul 2022, In: Radiology. 304, 1, p. 18-30 13 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Ultrasound-Guided Thrombin Injection for the Treatment of Bleeding Following Kidney and Liver Biopsies

Hoegger, M. J. & Middleton, W. D., Jan 2022, In: Journal of Ultrasound in Medicine. 41, 1, p. 247-253 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2021

Analysis of malignant thyroid nodules that do not meet ACR TI-RADS criteria for fine-needle aspiration

Middleton, W. D., Teefey, S. A., Tessler, F. N., Hoang, J. K., Reading, C. C., Langer, J. E., Beland, M. D., Szabunio, M. M. & Desser, T. S., Feb 2021, In: American Journal of Roentgenology. 216, 2, p. 471-478 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Comparison of Thyroid Risk Categorization Systems and Fine-Needle Aspiration Recommendations in a Multi-Institutional Thyroid Ultrasound Registry

Hoang, J. K., Middleton, W. D., Langer, J. E., Schmidt, K., Gillis, L. B., Nair, S. S., Watts, J. A., Snyder, R. W., Khot, R., Rawal, U. & Tessler, F. N., Dec 2021, In: Journal of the American College of Radiology. 18, 12, p. 1605-1613 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Effect of decreasing the ACR TI-RADS point assignment for punctate echogenic foci when they occur in mixed solid and cystic thyroid nodules

Teefey, S. A., Middleton, W. D., Reading, C. C., Langer, J. E., Beland, M. D., Szabunio, M. M. & Desser, T. S., Feb 2021, In: American Journal of Roentgenology. 216, 2, p. 479-485 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Mapping the Ultrasound Landscape to Define Point-of-Care Ultrasound and Diagnostic Ultrasound: A Proposal From the Society of Radiologists in Ultrasound and ACR Commission on Ultrasound

Patel, M. D., Horrow, M. M., Kamaya, A., Frates, M. C., Dahiya, N., Golding, L., Chong, W. K., Gerena, M., Ghate, S., Glanc, P., Goldbach, A. R., Gupta, S., Hill, P. A., Johnson, S. I., Kocher, M. R., Rubin, E., Sohaey, R., Waltz, J. T., Wolfman, D. J. & Middleton, W. D., Jan 2021, In: Journal of the American College of Radiology. 18, 1, p. 42-52 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Right-sided scrotal varicocele and its association with malignancy: a multi-institutional study

Itani, M., Kipper, B., Corwin, M. T., Burgan, C. M., Fetzer, D. T., Shenoy-Bhangle, A. S., Althubaity, A., Loehfelm, T. W., Middleton, W. D. & Fananapazir, G., May 2021, In: Abdominal Radiology. 46, 5, p. 2140-2145 6 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Role of blood oxygenation saturation in ovarian cancer diagnosis using multi-spectral photoacoustic tomography

Amidi, E., Yang, G., Uddin, K. M. S., Luo, H., Middleton, W., Powell, M., Siegel, C. & Zhu, Q., Apr 2021, In: Journal of Biophotonics. 14, 4, e202000368.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2020

Contrast-enhanced US for the interventional radiologist: Current and emerging applications

Malone, C. D., Fetzer, D. T., Monsky, W. L., Itani, M., Mellnick, V. M., Velez, P. A., Middleton, W. D., Averkiou, M. A. & Ramaswamy, R. S., Mar 1 2020, In: Radiographics. 40, 2, p. 562-588 27 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Guidelines for Ultrasound in the Radiology Department during the COVID-19 Pandemic

Sheth, S., Fetzer, D., Frates, M., Needleman, L., Middleton, W., Jones, J., Podrasky, A. & Gettle, L. M., 2020, In: Ultrasound Quarterly. 36, 3, p. 200-205 6 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Imaging of abdominal wall masses, masslike lesions, and diffuse processes

Ballard, D. H., Mazaheri, P., Oppenheimer, D. C., Lubner, M. G., Menias, C. O., Pickhardt, P. J., Middleton, W. D. & Mellnick, V. M., May 1 2020, In: Radiographics. 40, 3, p. 684-706 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Investigating the Effect of Thyroid Nodule Location on the Risk of Thyroid Cancer

Jasim, S., Baranski, T. J., Teefey, S. A. & Middleton, W. D., Mar 2020, In: Thyroid. 30, 3, p. 401-407 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

Method Comparison for Detection and Measurement of Rotator Cuff Tears: Office-based Bedside Ultrasonography by a Single Physiatrist versus Imaging Center–based Ultrasonography by Two Expert Musculoskeletal Radiologists

Tang, C. T., Decker, G., Steger-May, K., Middleton, W. & Teefey, S., Jun 1 2020, In: PM and R. 12, 6, p. 563-572 10 p.

Research output: Contribution to journal › Article › peer-review

Prevalence and risk factors for development of subscapularis and biceps pathology in shoulders with degenerative rotator cuff disease: a prospective cohort evaluation

Mehta, S. K., Teefey, S. A., Middleton, W., Steger-May, K., Sefko, J. A. & Keener, J. D., Mar 2020, In: Journal of Shoulder and Elbow Surgery. 29, 3, p. 451-458 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Thyroid Nodule Malignancy Risk Stratification Using a Convolutional Neural Network

Stib, M. T., Pan, I., Merck, D., Middleton, W. D. & Beland, M. D., 2020, In: Ultrasound Quarterly. 36, 2, p. 164-172 9 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Update on ACR TI-RADS: Successes, challenges, and future directions, from the AJR special series on radiology reporting and data systems

Hoang, J. K., Middleton, W. D. & Tessler, F. N., 2020, In: American Journal of Roentgenology. 216, 3, p. 570-578 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

2019

Classification of human ovarian cancer using functional, spectral, and imaging features obtained from in vivo photoacoustic imaging

Amidi, E., Mostafa, A., Nandy, S., Yang, G., Middleton, W., Siegel, C. & Zhu, Q., May 1 2019, In: Biomedical Optics Express. 10, 5, p. 2303-2317 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Formulating a Treatment Plan in Suspected Lymphoma: Ultrasound-Guided Core Needle Biopsy Versus Core Needle Biopsy and Fine-Needle Aspiration of Peripheral Lymph Nodes

Drylewicz, M. R., Watkins, M. P., Shetty, A. S., Lin, M. F., Salter, A., Bartlett, N. L., Middleton, W. D. & Yano, M., Mar 2019, In: Journal of Ultrasound in Medicine. 38, 3, p. 581-586 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Management of thyroid nodules seen on us images: Deep learning may match performance of radiologists

Buda, M., Wildman-Tobriner, B., Hoang, J. K., Thayer, D., Tessler, F. N., Middleton, W. D. & Mazurowski, M. A., 2019, In: Radiology. 292, 3, p. 695-701 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

158 Scopus citations

Using artificial intelligence to revise ACR TI-RADS risk stratification of thyroid nodules: Diagnostic accuracy and utility

Wildman-Tobriner, B., Buda, M., Hoang, J. K., Middleton, W. D., Thayer, D., Short, R. G., Tessler, F. N. & Mazurowski, M. A., 2019, In: Radiology. 292, 1, p. 112-119 8 p.

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

2018

Bleeding complications after percutaneous liver biopsy: Do subcapsular lesions pose a higher risk?

Potretzke, T. A., Saling, L. J., Middleton, W. D. & Robinson, K. A., Jul 2018, In: American Journal of Roentgenology. 211, 1, p. 204-210 7 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Comparison of performance characteristics of American college of radiology TI-RADS, Korean society of thyroid radiology TIRADS, and American thyroid association guidelines

Middleton, W. D., Teefey, S. A., Reading, C. C., Langer, J. E., Beland, M. D., Szabunio, M. M. & Desser, T. S., May 2018, In: American Journal of Roentgenology. 210, 5, p. 1148-1154 7 p.

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Interobserver variability of sonographic features used in the American college of radiology thyroid imaging reporting and data system

Hoang, J. K., Middleton, W. D., Farjat, A. E., Teefey, S. A., Abinanti, N., Boschini, F. J., Bronner, A. J., Dahiya, N., Hertzberg, B. S., Newman, J. R., Scanga, D., Vogler, R. C. & Tessler, F. N., Jul 2018, In: American Journal of Roentgenology. 211, 1, p. 162-167 6 p.

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Reduction in thyroid nodule biopsies and improved accuracy with American college of radiology thyroid imaging reporting and data system

Hoang, J. K., Middleton, W. D., Farjat, A. E., Langer, J. E., Reading, C. C., Teefey, S. A., Abinanti, N., Boschini, F. J., Bronner, A. J., Dahiya, N., Hertzberg, B. S., Newman, J. R., Scanga, D., Vogler, R. C. & Tessler, F. N., Apr 2018, In: Radiology. 287, 1, p. 185-193 9 p.

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Thyroid imaging reporting and data system (TI-RADS): A user's guide

Tessler, F. N., Middleton, W. D. & Grant, E. G., Apr 2018, In: Radiology. 287, 1, p. 29-36 8 p.

Research output: Contribution to journal › Article › peer-review

179 Scopus citations

2017

ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee

Tessler, F. N., Middleton, W. D., Grant, E. G., Hoang, J. K., Berland, L. L., Teefey, S. A., Cronan, J. J., Beland, M. D., Desser, T. S., Frates, M. C., Hammers, L. W., Hamper, U. M., Langer, J. E., Reading, C. C., Scoutt, L. M. & Stavros, A. T., May 2017, In: Journal of the American College of Radiology. 14, 5, p. 587-595 9 p.

Research output: Contribution to journal › Article › peer-review

1669 Scopus citations

Multiinstitutional analysis of thyroid nodule risk stratification using the American College of radiology thyroid imaging reporting and data system

Middleton, W. D., Teefey, S. A., Reading, C. C., Langer, J. E., Beland, M. D., Szabunio, M. M. & Desser, T. S., Jun 2017, In: American Journal of Roentgenology. 208, 6, p. 1331-1341 11 p.

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

2016

Testicular Microlithiasis: What should you recommend?

Winter, T. C., Kim, B., Lowrance, W. T. & Middleton, W. D., Jun 2016, In: American Journal of Roentgenology. 206, 6, p. 1164-1169 6 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

2015

A prospective evaluation of survivorship of asymptomatic degenerative rotator cuff tears

Keener, J. D., Galatz, L. M., Teefey, S. A., Middleton, W. D., Steger-May, K., Stobbs-Cucchi, G., Patton, R. & Yamaguchi, K., Jan 21 2015, In: Journal of Bone and Joint Surgery - American Volume. 97, 2, p. 89-98 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

Managing incidental thyroid nodules detected on imaging: White paper of the ACR incidental thyroid findings committee

Hoang, J. K., Langer, J. E., Middleton, W. D., Wu, C. C., Hammers, L. W., Cronan, J. J., Tessler, F. N., Grant, E. G. & Berland, L. L., Feb 1 2015, In: Journal of the American College of Radiology. 12, 2, p. 143-150 8 p.

Research output: Contribution to journal › Article › peer-review

277 Scopus citations

Misinterpretation of the American college of radiology white paper on managing incidental thyroid nodules

Hoang, J. K., Langer, J. E., Middleton, W. D., Wu, C. C., Hammers, L. W., Cronan, J. J., Tessler, F. N., Grant, E. G. & Berland, L. L., May 1 2015, In: Thyroid. 25, 5, p. 469-470 2 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

William Middleton

Research output

Search results