William Hawkins

Professor of Surgery, Neidorff Family and Robert C Packman Professor

    • 8301 Citations
    19992020

    Research output per year

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    Personal profile

    Research interests

    Our lab develops novel therapeutic approaches to the treatment of pancreatic cancer. One project aims to create a DNA vaccine against pancreatic cancer with special emphasis on our ability to translate our discoveries into clinical trials. In addition to the vaccines we also work on ways to augment the effects of the vaccinations by modulating the immune system using chemotherapy and biologic agents. We also have developed novel therapeutics which are selective for pancreas cancer and which restore the cancers cells ability to undergo cell death (Apoptosis). All work is done with emphasis on early stage (phase I) clinical trials.

    Areas of Clinical Interest

    Minimally invasive foregut and solid organ surgery, pancreatic cancer, liver cancer, sarcoma, abdominal wall hernia, and biliary tract disease, hepatocellular cancer, hepatoma, gastric cancer, revision surgery

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    Research Output

    A 22-year experience with pancreatic resection for metastatic renal cell carcinoma

    Anderson, B., Williams, G. A., Sanford, D. E., Lu, J., Dageforde, L. A., Hammill, C. W., Fields, R. C., Hawkins, W. G., Strasberg, S. M., Doyle, M. B., Chapman, W. C. & Khan, A. S., Feb 2020, In : HPB. 22, 2, p. 312-317 6 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Ablative Five-Fraction Stereotactic Body Radiation Therapy for Inoperable Pancreatic Cancer Using Online MR-Guided Adaptation

    Hassanzadeh, C., Rudra, S., Bommireddy, A., Hawkins, W. G., Wang-Gillam, A., Fields, R. C., Cai, B., Park, J., Green, O., Roach, M., Henke, L. & Kim, H., 2020, (Accepted/In press) In : Advances in Radiation Oncology.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Assessment of Hepatic Arterial Infusion of Floxuridine in Combination with Systemic Gemcitabine and Oxaliplatin in Patients with Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial

    Cercek, A., Boerner, T., Tan, B. R., Chou, J. F., Gönen, M., Boucher, T. M., Hauser, H. F., Do, R. K. G., Lowery, M. A., Harding, J. J., Varghese, A. M., Reidy-Lagunes, D., Saltz, L., Schultz, N., Kingham, T. P., D'Angelica, M. I., Dematteo, R. P., Drebin, J. A., Allen, P. J., Balachandran, V. P. & 11 others, Lim, K. H., Sanchez-Vega, F., Vachharajani, N., Majella Doyle, M. B., Fields, R. C., Hawkins, W. G., Strasberg, S. M., Chapman, W. C., Diaz, L. A., Kemeny, N. E. & Jarnagin, W. R., Jan 2020, In : JAMA oncology. 6, 1, p. 60-67 8 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Bcell-derived IL35 drives STAT3-DependentCD8+ T-cell exclusion in pancreatic cancer

    Mirlekar, B., Michaud, D., Lee, S. J., Kren, N. P., Harris, C., Greene, K., Goldman, E. C., Gupta, G. P., Fields, R. C., Hawkins, W. G., DeNardo, D. G., Rashid, N. U., Yeh, J. J., McRee, A. J., Vincent, B. G., Vignali, D. A. A. & Pylayeva-Gupta, Y., Mar 1 2020, In : Cancer immunology research. 8, 3, p. 292-308 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations