William Buchser

2480

Citations

Research activity per year

Research interests

Idiopathic diseases (particularly neuro-degenerative and oncologic) continue to make diagnosis and treatment difficult due to their undefined nature. Many of these diseases have a heritable component, and for some, it is the primary underlying etiology. With Whole Exome Sequence from a variety of patients, the identification of a large set of putative disease-causing variants is feasible. The remaining issue is to definitively identify the small set of variants that are truly causative in these polygenic conditions. We utilize new precision medicine pipelines to functionally test combinations of variants in cellular systems.

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41 Article
2 Review article
1 Chapter
1 Conference contribution
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- 1 Editorial
- 1 Short survey

Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation
Yurube, T., Buchser, W. J., Zhang, Z., Silwal, P., Lotze, M. T., Kang, J. D., Sowa, G. A. & Vo, N. V., Mar 2024, In: JOR Spine. 7, 1, e1303.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination
Greene, S. E., Huang, Y., Kim, W., Liebeskind, M. J., Chandrasekaran, V., Liu, Z., Deepak, P., Paley, M. A., Lew, D., Yang, M., Matloubian, M., Gensler, L. S., Nakamura, M. C., O'Hallaran, J. A., Presti, R. M., Whelan, S. P. J., Buchser, W. J., Kim, A. H. J. & Weil, G. J., Feb 2023, In: Journal of Clinical Virology Plus. 3, 1, 100135.
Research output: Contribution to journal › Article › peer-review

Open Access
The DUSP domain of pseudophosphatase MK-STYX interacts with G3BP1 to decrease stress granules
Smailys, J., Jiang, F., Prioleau, T., Kelley, K., Mitchell, O., Nour, S., Ali, L., Buchser, W., Zavada, L. & Hinton, S. D., Aug 2023, In: Archives of Biochemistry and Biophysics. 744, 109702.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes
Zaydman, M. A., Little, A. S., Haro, F., Aksianiuk, V., Buchser, W. J., Diantonio, A., Gordon, J. I., Milbrandt, J. & Raman, A. S., 2022, In: eLife. 11, e74104.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Defining the risk of SARS-CoV-2 variants on immune protection
DeGrace, M. M., Ghedin, E., Frieman, M. B., Krammer, F., Grifoni, A., Alisoltani, A., Alter, G., Amara, R. R., Baric, R. S., Barouch, D. H., Bloom, J. D., Bloyet, L. M., Bonenfant, G., Boon, A. C. M., Boritz, E. A., Bratt, D. L., Bricker, T. L., Brown, L., Buchser, W. J. & Carreño, J. M. & 110 others, Cohen-Lavi, L., Darling, T. L., Davis-Gardner, M. E., Dearlove, B. L., Di, H., Dittmann, M., Doria-Rose, N. A., Douek, D. C., Drosten, C., Edara, V. V., Ellebedy, A., Fabrizio, T. P., Ferrari, G., Fischer, W. M., Florence, W. C., Fouchier, R. A. M., Franks, J., García-Sastre, A., Godzik, A., Gonzalez-Reiche, A. S., Gordon, A., Haagmans, B. L., Halfmann, P. J., Ho, D. D., Holbrook, M. R., Huang, Y., James, S. L., Jaroszewski, L., Jeevan, T., Johnson, R. M., Jones, T. C., Joshi, A., Kawaoka, Y., Kercher, L., Koopmans, M. P. G., Korber, B., Koren, E., Koup, R. A., LeGresley, E. B., Lemieux, J. E., Liebeskind, M. J., Liu, Z., Livingston, B., Logue, J. P., Luo, Y., McDermott, A. B., McElrath, M. J., Meliopoulos, V. A., Menachery, V. D., Montefiori, D. C., Mühlemann, B., Munster, V. J., Munt, J. E., Nair, M. S., Netzl, A., Niewiadomska, A. M., O’Dell, S., Pekosz, A., Perlman, S., Pontelli, M. C., Rockx, B., Rolland, M., Rothlauf, P. W., Sacharen, S., Scheuermann, R. H., Schmidt, S. D., Schotsaert, M., Schultz-Cherry, S., Seder, R. A., Sedova, M., Sette, A., Shabman, R. S., Shen, X., Shi, P. Y., Shukla, M., Simon, V., Stumpf, S., Sullivan, N. J., Thackray, L. B., Theiler, J., Thomas, P. G., Trifkovic, S., Türeli, S., Turner, S. A., Vakaki, M. A., van Bakel, H., VanBlargan, L. A., Vincent, L. R., Wallace, Z. S., Wang, L., Wang, M., Wang, P., Wang, W., Weaver, S. C., Webby, R. J., Weiss, C. D., Wentworth, D. E., Weston, S. M., Whelan, S. P. J., Whitener, B. M., Wilks, S. H., Xie, X., Ying, B., Yoon, H., Zhou, B., Hertz, T., Smith, D. J., Diamond, M. S., Post, D. J. & Suthar, M. S., May 26 2022, In: Nature. 605, 7911, p. 640-652 13 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
104 Scopus citations

William Buchser

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Research interests

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Collaborations and top research areas from the last five years

Dive into details

Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination

The DUSP domain of pseudophosphatase MK-STYX interacts with G3BP1 to decrease stress granules

Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

Defining the risk of SARS-CoV-2 variants on immune protection

William Buchser

Personal profile

Research interests

Fingerprint

Collaborations and top research areas from the last five years

Research output

Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination

The DUSP domain of pseudophosphatase MK-STYX interacts with G3BP1 to decrease stress granules

Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

Defining the risk of SARS-CoV-2 variants on immune protection