• 849 Citations

Research output per year

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Personal profile

Research interests

Idiopathic diseases (particularly neuro-degenerative and oncologic) continue to make diagnosis and treatment difficult due to their undefined nature. Many of these diseases have a heritable component, and for some, it is the primary underlying etiology. With Whole Exome Sequence from a variety of patients, the identification of a large set of putative disease-causing variants is feasible. The remaining issue is to definitively identify the small set of variants that are truly causative in these polygenic conditions. We utilize new precision medicine pipelines to functionally test combinations of variants in cellular systems.

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Research Output

Domain-centric database to uncover structure of minimally characterized viral genomes

Bramley, J. C., Yenkin, A. L., Zaydman, M. A., DiAntonio, A., Milbrandt, J. D. & Buchser, W. J., Dec 1 2020, In : Scientific data. 7, 1, 202.

Research output: Contribution to journalArticle

Open Access
  • Planning and analysis of axon degeneration screening experiments

    Lovell, L., Bramley, J. & Buchser, W., 2020, Methods in Molecular Biology. Humana Press Inc., p. 63-82 20 p. (Methods in Molecular Biology; vol. 2143).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium

    Russell, K. L., Gorgulho, C. M., Allen, A., Vakaki, M., Wang, Y., Facciabene, A., Lee, D., Roy, P., Buchser, W. J., Appleman, L. J., Maranchie, J., Storkus, W. J. & Lotze, M. T., May 1 2019, In : Cancer Journal (United States). 25, 3, p. 165-177 13 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study

    Yurube, T., Buchser, W. J., Moon, H. J., Hartman, R. A., Takayama, K., Kawakami, Y., Nishida, K., Kurosaka, M., Vo, N. V., Kang, J. D., Lotze, M. T. & Sowa, G. A., May 1 2019, In : European Spine Journal. 28, 5, p. 993-1004 12 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Data Descriptor: High content screen for identifying smallmolecule LC3B-localization modulators in a renal cancer cell line

    Kolla, L., Heo, D. S., Rosenberg, D. P., Barlow, S. A., Maximova, A. A., Cassio, E. E. & Buchser, W. J., Jun 26 2018, In : Scientific data. 5, 180116.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations