• 12157 Citations
1988 …2020

Research output per year

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Personal profile

Research interests

Current research interests include investigation of hepatic ischemia-reperfusion injury, especially in the setting of liver and kidney transplantation as well as in liver resectional surgery. Basic investigations include the role of NF-?B and ER stress modulation of events associated with ischemia-reperfusion in the normal liver as well as in the setting of moderate to severe hepatic steatosis. We have an experienced staff of transplant and liver microsurgeons who have developed a rodent model of liver resectional surgery and liver transplantation to investigate ischemia reperfusion injury. In addition we have a significant infrastructure in place to support our clinical trials for ongoing clinical investigations, and maintain around 20 active trials at any given time. A second area of research focus includes the development of image-guidance in liver surgery. This clinical area of biomedical research includes the development of techniques to utilize preoperative cross-sectional imaging (CT and MR) in the conduct of liver resectional surgery as well as in ablative therapy for liver tumors. In addition to these basic research investigations, we also have a very active clinical trials group investigating new strategies for immunosuppression following liver and kidney transplantation. In addition, we have open studies investigating approved techniques for hemostatic adjuncts in patients undergoing liver resectional surgery.

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

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Research Output

A 22-year experience with pancreatic resection for metastatic renal cell carcinoma

Anderson, B., Williams, G. A., Sanford, D. E., Lu, J., Dageforde, L. A., Hammill, C. W., Fields, R. C., Hawkins, W. G., Strasberg, S. M., Doyle, M. B., Chapman, W. C. & Khan, A. S., Feb 2020, In : HPB. 22, 2, p. 312-317 6 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Adaptive Boosting (AdaBoost)-based multiwavelength spatial frequency domain imaging and characterization for ex vivo human colorectal tissue assessment

    Li, S., Zeng, Y., Chapman, W. C., Erfanzadeh, M., Nandy, S., Mutch, M. & Zhu, Q., Jun 1 2020, In : Journal of Biophotonics. 13, 6, e201960241.

    Research output: Contribution to journalArticle

  • Assessment of Hepatic Arterial Infusion of Floxuridine in Combination with Systemic Gemcitabine and Oxaliplatin in Patients with Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial

    Cercek, A., Boerner, T., Tan, B. R., Chou, J. F., Gönen, M., Boucher, T. M., Hauser, H. F., Do, R. K. G., Lowery, M. A., Harding, J. J., Varghese, A. M., Reidy-Lagunes, D., Saltz, L., Schultz, N., Kingham, T. P., D'Angelica, M. I., Dematteo, R. P., Drebin, J. A., Allen, P. J., Balachandran, V. P. & 11 others, Lim, K. H., Sanchez-Vega, F., Vachharajani, N., Majella Doyle, M. B., Fields, R. C., Hawkins, W. G., Strasberg, S. M., Chapman, W. C., Diaz, L. A., Kemeny, N. E. & Jarnagin, W. R., Jan 2020, In : JAMA oncology. 6, 1, p. 60-67 8 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system

    Yang, G., Amidi, E., Chapman, W., Luo, H., Huang, K., Nandy, S., Mostafa, A., Shihab Uddin, K. M., Zhou, S., Abdelal, H., Alipour, Z., Chatterjee, D., Mutch, M. & Zhu, Q., Jan 1 2020, Photons Plus Ultrasound: Imaging and Sensing 2020. Oraevsky, A. A. & Wang, L. V. (eds.). SPIE, 112400A. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11240).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • Clinicopathologic determinants of pathologic treatment response in neoadjuvant treated rectal adenocarcinoma

    González, I., Bauer, P. S., Chapman, W. C., Alipour, Z., Rais, R., Liu, J. & Chatterjee, D., Apr 2020, In : Annals of Diagnostic Pathology. 45, 151452.

    Research output: Contribution to journalArticle

  • 1 Scopus citations