Wenhua Chu

Michel, L. S., Dyroff, S., Brooks, F. J., Spayd, K. J., Lim, S., Engle, J. T., Phillips, S., Tan, B., Wang-Gillam, A., Bognar, C., Chu, W., Zhou, D., Mach, R. H., Laforest, R. & Chen, D. L., Apr 2019, In: Radiology. 291, 1, p. 271 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

2 Scopus citations

2018

Copper-mediated nucleophilic radiobromination of aryl boron precursors: Convenient preparation of a radiobrominated PARP-1 inhibitor

Zhou, D., Chu, W., Voller, T. & Katzenellenbogen, J. A., May 16 2018, In: Tetrahedron Letters. 59, 20, p. 1963-1967 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation

Hou, C., Hsieh, C. J., Li, S., Lee, H., Graham, T. J., Xu, K., Weng, C. C., Doot, R. K., Chu, W., Chakraborty, S. K., Dugan, L. L., Mintun, M. A. & Mach, R. H., Mar 21 2018, In: ACS Chemical Neuroscience. 9, 3, p. 578-586 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Preliminary evaluation of a novel ¹⁸F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer

Zhou, D., Xu, J., Mpoy, C., Chu, W., Kim, S. H., Li, H., Rogers, B. E. & Katzenellenbogen, J. A., Nov 2018, In: Nuclear Medicine and Biology. 66, p. 26-31 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2017

Evaluation of aromatic radiobromination by nucleophilic substitution using diaryliodonium salt precursors

Zhou, D., Kim, S. H., Chu, W., Voller, T. & Katzenellenbogen, J. A., Jul 1 2017, In: Journal of Labelled Compounds and Radiopharmaceuticals. 60, 9, p. 450-456 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

PET of poly (ADP-ribose) polymerase activity in cancer: Preclinical assessment and first in-human studies

Michel, L. S., Dyroff, S., Brooks, F. J., Spayd, K. J., Lim, S., Engle, J. T., Phillips, S., Tan, B., Wang-Gillam, A., Bognar, C., Chu, W., Zhou, D., MacH, R. H., Laforest, R. & Chen, D. L., Mar 2017, In: Radiology. 282, 2, p. 453-463 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells

McDonald, E. S., Mankoff, J., Makvandi, M., Chu, W., Chu, Y., Mach, R. H. & Zeng, C., May 6 2017, In: Biochemical and Biophysical Research Communications. 486, 3, p. 788-795 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2016

Optimized and automated radiosynthesis of [¹⁸F]DHMT for translational imaging of reactive oxygen species with positron emission tomography

Zhang, W., Cai, Z., Li, L., Ropchan, J., Lim, K., Boutagy, N. E., Wu, J., Stendahl, J. C., Chu, W., Gropler, R., Sinusas, A. J., Liu, C. & Huang, Y., Dec 1 2016, In: Molecules. 21, 12, 1696.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2015

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils

Chu, W., Zhou, D., Gaba, V., Liu, J., Li, S., Peng, X., Xu, J., Dhavale, D., Bagchi, D. P., D'Avignon, A., Shakerdge, N. B., Bacskai, B. J., Tu, Z., Kotzbauer, P. T. & Mach, R. H., Jul 15 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6002-6017 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

Facile purification and click labeling with 2-[¹⁸F]fluoroethyl azide using solid phase extraction cartridges

Zhou, D., Chu, W., Peng, X., McConathy, J., Mach, R. H. & Katzenellenbogen, J. A., Feb 11 2015, In: Tetrahedron Letters. 56, 7, p. 952-954 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Imaging Caspase-3 Activation as a Marker of Apoptosis-Targeted Treatment Response in Cancer

Chen, D. L., Engle, J. T., Griffin, E. A., Miller, J. P., Chu, W., Zhou, D. & Mach, R. H., Jun 1 2015, In: Molecular Imaging and Biology. 17, 3, p. 384-393 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Imaging pulmonary inducible nitric oxide synthase expression with PET

Huang, H. J., Isakow, W., Byers, D. E., Engle, J. T., Griffin, E. A., Kemp, D., Brody, S. L., Gropler, R. J., Miller, J. P., Chu, W., Zhou, D., Pierce, R. A., Castro, M., Mach, R. H. & Chen, D. L., Jan 1 2015, In: Journal of Nuclear Medicine. 56, 1, p. 76-81 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

2014

Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo

Chu, W., Chepetan, A., Zhou, D., Shoghi, K. I., Xu, J., Dugan, L. L., Gropler, R. J., Mintun, M. A. & Mach, R. H., Jul 7 2014, In: Organic and Biomolecular Chemistry. 12, 25, p. 4421-4431 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Functional assays to define agonists and antagonists of the sigma-2 receptor

Zeng, C., Rothfuss, J. M., Zhang, J., Vangveravong, S., Chu, W., Li, S., Tu, Z., Xu, J. & Mach, R. H., Mar 1 2014, In: Analytical Biochemistry. 448, 1, p. 68-74 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Synthesis, [¹⁸F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography

Zhou, D., Chu, W., Xu, J., Jones, L. A., Peng, X., Li, S., Chen, D. L. & Mach, R. H., Mar 1 2014, In: Bioorganic and Medicinal Chemistry. 22, 5, p. 1700-1707 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ₂ receptor ligands

Bai, S., Li, S., Xu, J., Peng, X., Sai, K., Chu, W., Tu, Z., Zeng, C. & Mach, R. H., May 22 2014, In: Journal of Medicinal Chemistry. 57, 10, p. 4239-4251 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2013

Positron emission tomography imaging of dopamine D₂ receptors using a highly selective radiolabeled D₂ receptor partial agonist

Xu, J., Vangveravong, S., Li, S., Fan, J., Jones, L. A., Cui, J., Wang, R., Tu, Z., Chu, W., Perlmutter, J. S. & Mach, R. H., May 1 2013, In: NeuroImage. 71, p. 168-174 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2012

Highly efficient click labeling using 2-[¹⁸F]fluoroethyl azide and synthesis of an ¹⁸FN-hydroxysuccinimide ester as conjugation agent

Zhou, D., Chu, W., Dence, C. S., Mach, R. H. & Welch, M. J., Nov 2012, In: Nuclear Medicine and Biology. 39, 8, p. 1175-1181 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody

Chen, D. L., Zhou, D., Chu, W., Herrbrich, P., Engle, J. T., Griffin, E., Jones, L. A., Rothfuss, J. M., Geraci, M., Hotchkiss, R. S. & Mach, R. H., Jan 2012, In: Nuclear Medicine and Biology. 39, 1, p. 137-144 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Sigma-2 ligands induce tumour cell death by multiple signalling pathways

Zeng, C., Rothfuss, J., Zhang, J., Chu, W., Vangveravong, S., Tu, Z., Pan, F., Chang, K. C., Hotchkiss, R. & Mach, R. H., Feb 14 2012, In: British Journal of Cancer. 106, 4, p. 693-701 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

Synthesis, radiolabeling and initial in vivo evaluation of [ ¹¹C]KSM-01 for imaging PPAR-α receptors

Solingapuram Sai, K. K., Kil, K. E., Tu, Z., Chu, W., Finck, B. N., Rothfuss, J. M., Shoghi, K. I., Welch, M. J., Gropler, R. J. & Mach, R. H., Oct 1 2012, In: Bioorganic and Medicinal Chemistry Letters. 22, 19, p. 6233-6236 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2011

Effect of cyclosporin A on the uptake of D₃-selective PET radiotracers in rat brain

Tu, Z., Li, S., Xu, J., Chu, W., Jones, L. A., Luedtke, R. R. & Mach, R. H., Jul 2011, In: Nuclear Medicine and Biology. 38, 5, p. 725-739 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

Xu, J., Zeng, C., Chu, W., Pan, F., Rothfuss, J. M., Zhang, F., Tu, Z., Zhou, D., Zeng, D., Vangveravong, S., Johnston, F., Spitzer, D., Chang, K. C., Hotchkiss, R. S., Hawkins, W. G., Wheeler, K. T. & MacH, R. H., 2011, In: Nature communications. 2, 1, 380.

Research output: Contribution to journal › Article › peer-review

Open Access

282 Scopus citations

Resorufin analogs preferentially bind cerebrovascular amyloid: Potential use as imaging ligands for cerebral amyloid angiopathy

Han, B. H., Zhou, M. L., Vellimana, A. K., Milner, E., Kim, D. H., Greenberg, J. K., Chu, W., MacH, R. H. & Zipfel, G. J., 2011, In: Molecular neurodegeneration. 6, 1, 86.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay

Chu, W., Rothfuss, J., Zhou, D. & MacH, R. H., Apr 15 2011, In: Bioorganic and Medicinal Chemistry Letters. 21, 8, p. 2192-2197 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2010

[³H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)- butyl)benzamide: A selective radioligand for dopamine D₃ receptors. II. Quantitative analysis of dopamine D₃ and D₂ receptor density ratio in the caudate-putamen

Xu, J., Hassanzadeh, B., Chu, W., Tu, Z., Jones, L. A., Luedtke, R. R., Perlmutter, J. S., Mintun, M. A. & Mach, R. H., Jun 2010, In: Synapse. 64, 6, p. 449-459 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2009

[¹⁸F]- and [¹¹C]-Labeled N-benzyl-isatin sulfonamide analogues as PET tracers for Apoptosis: Synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [ ¹¹C]WC-98

Zhou, D., Chu, W., Chen, D. L., Wang, Q., Reichert, D. E., Rothfuss, J., D'Avignon, A., Welch, M. J. & MacH, R. H., 2009, In: Organic and Biomolecular Chemistry. 7, 7, p. 1337-1348 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

[³H]4-(dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl]benzamide, a selective radioligand for dopamine D₃ receptors. I. In vitro characterization

Xu, J., Chu, W., Tu, Z., Jones, L. A., Luedtke, R. R., Perlmutter, J. S., Mintun, M. A. & Mach, R. H., Sep 2009, In: Synapse. 63, 9, p. 717-728 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography

Chen, D. L., Zhou, D., Chu, W., Herrbrich, P. E., Jones, L. A., Rothfuss, J. M., Engle, J. T., Geraci, M., Welch, M. J. & Mach, R. H., Aug 2009, In: Nuclear Medicine and Biology. 36, 6, p. 651-658 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in rats

Kumar, R., Riddle, L. R., Griffin, S. A., Chu, W., Vangveravong, S., Neisewander, J., Mach, R. H. & Luedtke, R. R., May 2009, In: Neuropharmacology. 56, 6-7, p. 956-969 14 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ₂ receptor ligands: Synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents

Chu, W., Xu, J., Zhou, D., Zhang, F., Jones, L. A., Wheeler, K. T. & Mach, R. H., Feb 1 2009, In: Bioorganic and Medicinal Chemistry. 17, 3, p. 1222-1231 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6

Chu, W., Rothfuss, J., Chu, Y., Zhou, D. & Mach, R. H., Apr 23 2009, In: Journal of Medicinal Chemistry. 52, 8, p. 2188-2191 4 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

2007

Isatin sulfonamide analogs containing a Michael addition acceptor: A new class of caspase 3/7 inhibitors

Chu, W., Rothfuss, J., D'Avignon, A., Zeng, C., Zhou, D., Hotchkiss, R. S. & Mach, R. H., Jul 26 2007, In: Journal of Medicinal Chemistry. 50, 15, p. 3751-3755 5 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

2006

Synthesis, radiolabeling, and in vivo evaluation of an ¹⁸F-labeled isatin analog for imaging caspase-3 activation in apoptosis

Zhou, D., Chu, W., Rothfuss, J., Zeng, C., Xu, J., Jones, L., Welch, M. J. & Mach, R. H., Oct 1 2006, In: Bioorganic and Medicinal Chemistry Letters. 16, 19, p. 5041-5046 6 p.

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

2005

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: Synthesis, in vitro activity, and molecular modeling studies

Chu, W., Zhang, J., Zeng, C., Rothfuss, J., Tu, Z., Chu, Y., Reichert, D. E., Welch, M. J. & Mach, R. H., Dec 1 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7637-7647 11 p.

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D ₃ receptor ligands

Chu, W., Tu, Z., McElveen, E., Xu, J., Taylor, M., Luedtke, R. R. & MacH, R. H., Jan 3 2005, In: Bioorganic and Medicinal Chemistry. 13, 1, p. 77-87 11 p.

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Synthesis and in vivo evaluation of [¹¹C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis

Tu, Z., Chu, W., Zhang, J., Dence, C. S., Welch, M. J. & Mach, R. H., Jul 2005, In: Nuclear Medicine and Biology. 32, 5, p. 437-443 7 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

2000

Anodic amide oxidation/olefin metathesis strategies: Developing a unified approach to the synthesis of bicyclic lactam peptidomimetics

Beal, L. M., Liu, B., Chu, W. & Moeller, K. D., Dec 22 2000, In: Tetrahedron. 56, 52, p. 10113-10125 13 p.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

1999

The synthesis of bicyclic lactam based His-Pro building blocks: The effect of substituent polarity on an intramolecular bond migration

Chu, W. & Moeller, K. D., Nov 5 1999, In: Tetrahedron Letters. 40, 45, p. 7939-7943 5 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

1998

Thyrotropin releasing hormone analogs: A building block approach to the construction of tetracyclic peptidomimetics

Chu, W., Perlman, J. H., Gershengorn, M. C. & Moeller, K. D., Nov 1998, In: Bioorganic and Medicinal Chemistry Letters. 8, 21, p. 3093-3096 4 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Wenhua Chu

Research output

Search results