Wayne Yokoyama

2022

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

Yang, X., Garner, L. I., Zvyagin, I. V., Paley, M. A., Komech, E. A., Jude, K. M., Zhao, X., Fernandes, R. A., Hassman, L. M., Paley, G. L., Savvides, C. S., Brackenridge, S., Quastel, M. N., Chudakov, D. M., Bowness, P., Yokoyama, W. M., McMichael, A. J., Gillespie, G. M. & Garcia, K. C., Dec 22 2022, In: Nature. 612, 7941, p. 771-777 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis

Bigley, T. M., Yang, L., Kang, L. I., Saenz, J. B., Victorino, F. & Yokoyama, W. M., Mar 7 2022, In: Journal of Experimental Medicine. 219, 3, e20211403.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Human NK cells confer protection against HIV-1 infection in humanized mice

Sungur, C. M., Wang, Q., Ozantürk, A. N., Gao, H., Schmitz, A. J., Cella, M., Yokoyama, W. M. & Shan, L., Dec 15 2022, In: Journal of Clinical Investigation. 132, 24, e162694.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

Bigley, T. M., Xiong, M., Ali, M., Chen, Y., Wang, C., Serrano, J. R., Eteleeb, A., Harari, O., Yang, L., Patel, S. J., Cruchaga, C., Yokoyama, W. M. & Holtzman, D. M., Dec 2022, In: Molecular neurodegeneration. 17, 1, 10.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells

Paley, M. A., Baker, B. J., Dunham, S. R., Linskey, N., Cantoni, C., Lee, K., Hassman, L. M., Laurent, J., Roberson, E. D. O., Clifford, D. B. & Yokoyama, W. M., Jun 15 2022, In: Journal of Neuroimmunology. 367, 577860.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function

Li, S., Bern, M. D., Miao, B., Fan, C., Xing, X., Inoue, T., Piersma, S. J., Wang, T., Colonna, M., Kurosaki, T. & Yokoyama, W. M., 2022, In: eLife. 11, e77294.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Hif1α is required for nk cell metabolic adaptation during virus infection

Victorino, F., Bigley, T. M., Park, E., Yao, C. H., Benoit, J., Yang, L. P., Piersma, S. J., Lauron, E. J., Davidson, R. M., Patti, G. J. & Yokoyama, W. M., Aug 2021, In: eLife. 10, e68484.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Hobit confers tissue-dependent programs to type 1 innate lymphoid cells

Yomogida, K., Bigley, T. M., Trsan, T., Gilfillan, S., Cella, M., Yokoyama, W. M., Egawa, T. & Colonna, M., Dec 14 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 50, e2117965118.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Identification of a t-bethi quiescent exhausted cd8 t cell subpopulation that can differentiate into tim3+cx3cr1+ effectors and memory-like cells

Raju, S., Xia, Y., Daniel, B., Yost, K. E., Bradshaw, E., Tonc, E., Verbaro, D. J., Kometani, K., Yokoyama, W. M., Kurosaki, T., Satpathy, A. T. & Egawa, T., Jun 15 2021, In: Journal of Immunology. 206, 12, p. 2924-2936 13 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Innovations in MD-only physician-scientist training: Experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative

McElvaine, A. T., Hawkins-Salsbury, J. A., Arora, V. M., Gladwin, M. T., Goldenring, J. R., Huston, D. P., Krakow, D., Rhee, K., Solway, J., Steinman, R. A., Towler, D. A., Utz, P. J., Yokoyama, W. M., Simpson, R. L., Muglia, L. J., Permar, S. R. & Gbadegesin, R. A., May 2021, In: Journal of Clinical Investigation. 131, 10, e149948.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2020

Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis

Mack, M. R., Brestoff, J. R., Berrien-Elliott, M. M., Trier, A. M., Yang, T. L. B., McCullen, M., Collins, P. L., Niu, H., Bodet, N. D., Wagner, J. A., Park, E., Xu, A. Z., Wang, F., Chibnall, R., Council, M. L., Heffington, C., Kreisel, F., Margolis, D. J., Sheinbein, D., Lovato, P., & 7 othersVivier, E., Cella, M., Colonna, M., Yokoyama, W. M., Oltz, E. M., Fehniger, T. A. & Kim, B. S., Feb 26 2020, In: Science translational medicine. 12, 532, aay1005.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

cDC1 prime and are licensed by CD4⁺ T cells to induce anti-tumour immunity

Ferris, S. T., Durai, V., Wu, R., Theisen, D. J., Ward, J. P., Bern, M. D., Davidson, J. T., Bagadia, P., Liu, T., Briseño, C. G., Li, L., Gillanders, W. E., Wu, G. F., Yokoyama, W. M., Murphy, T. L., Schreiber, R. D. & Murphy, K. M., Aug 27 2020, In: Nature. 584, 7822, p. 624-629 6 p.

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Control of Viral Infection by Natural Killer Cell Inhibitory Receptors

Parikh, B. A., Bern, M. D., Piersma, S. J., Yang, L., Beckman, D. L., Poursine-Laurent, J., Plougastel-Douglas, B. & Yokoyama, W. M., Jul 28 2020, In: Cell Reports. 32, 4, 107969.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

T cell response kinetics determines neuroinfection outcomes during murine HSV infection

Lee, A. G., Scott, J. M., Fabbrizi, M. R., Jiang, X., Sojka, D. K., Miller, M. J., Baldridge, M. T., Yokoyama, W. M. & Shin, H., Mar 12 2020, In: JCI Insight. 5, 5, e134258.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through sting

Piersma, S. J., Poursine-Laurent, J., Yang, L., Barber, G. N., Parikh, B. A. & Yokoyama, W. M., Jul 2020, In: eLife. 9, p. 1-21 21 p., e56882.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2019

Activation receptor–dependent IFN-g production by NK cells is controlled by transcription, translation, and the proteasome

Piersma, S. J., Pak-Wittel, M. A., Lin, A., Plougastel-Douglas, B. & Yokoyama, W. M., Oct 1 2019, In: Journal of Immunology. 203, 7, p. 1981-1988 8 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation

Wang, X., Piersma, S. J., Elliott, J. I., Errico, J. M., Gainey, M. D., Yang, L., Nelson, C. A., Yokoyama, W. M. & Fremont, D. H., Oct 15 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 42, p. 21113-21119 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

First-onset herpesviral infection and lung injury in allogeneic hematopoietic cell transplantation

Zhou, X., O'Dwyer, D. N., Xia, M., Miller, H. K., Chan, P. R., Trulik, K., Chadwick, M. M., Hoffman, T. C., Bulte, C., Sekerak, K., Wilke, C. A., Patel, S. J., Yokoyama, W. M., Murray, S., Yanik, G. A. & Moore, B. B., 2019, In: American journal of respiratory and critical care medicine. 200, 1, p. 63-74 12 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

Ardain, A., Domingo-Gonzalez, R., Das, S., Kazer, S. W., Howard, N. C., Singh, A., Ahmed, M., Nhamoyebonde, S., Rangel-Moreno, J., Ogongo, P., Lu, L., Ramsuran, D., de la Luz Garcia-Hernandez, M., K. Ulland, T., Darby, M., Park, E., Karim, F., Melocchi, L., Madansein, R., Dullabh, K. J., & 16 othersDunlap, M., Marin-Agudelo, N., Ebihara, T., Ndung’u, T., Kaushal, D., Pym, A. S., Kolls, J. K., Steyn, A., Zúñiga, J., Horsnell, W., Yokoyama, W. M., Shalek, A. K., Kløverpris, H. N., Colonna, M., Leslie, A. & Khader, S. A., Jun 27 2019, In: Nature. 570, 7762, p. 528-532 5 p.

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Inducible down-regulation of MHC class I results in natural killer cell tolerance

Bern, M. D., Parikh, B. A., Yang, L., Beckman, D. L., Poursine‑Laurent, J. & Yokoyama, W. M., Jan 1 2019, In: Journal of Experimental Medicine. 216, 1, p. 99-116 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

In the absence of natural killer cell activation donor-specific antibody mediates chronic, but not acute, kidney allograft rejection

Yagisawa, T., Tanaka, T., Miyairi, S., Tanabe, K., Dvorina, N., Yokoyama, W. M., Valujskikh, A., Baldwin, W. M. & Fairchild, R. L., Feb 2019, In: Kidney International. 95, 2, p. 350-362 13 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9

Stephens, C. J., Lauron, E. J., Kashentseva, E., Lu, Z. H., Yokoyama, W. M. & Curiel, D. T., Mar 28 2019, In: Journal of Controlled Release. 298, p. 128-141 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection

Matta, S. K., Olias, P., Huang, Z., Wang, Q., Park, E., Yokoyama, W. M. & Sibley, L. D., Aug 27 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17480-17491 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

Park, E., Patel, S., Wang, Q., Andhey, P., Zaitsev, K., Porter, S., Hershey, M., Bern, M., Plougastel-Douglas, B., Collins, P., Colonna, M., Murphy, K. M., Oltz, E., Artyomov, M., Sibley, L. D. & Yokoyama, W. M., Aug 2019, In: eLife. 8, e47605.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges

Jash, A., Zhou, Y. W., Gerardo, D. K., Ripperger, T. J., Parikh, B. A., Piersma, S., Jamwal, D. R., Kiela, P. R., Boon, A. C. M., Yokoyama, W. M., Hsieh, C. S. & Bhattacharya, D., Dec 1 2019, In: Scientific reports. 9, 1, 15257.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2018

A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

Wang, X., Piersma, S. J., Nelson, C. A., Dai, Y. N., Christensen, T., Lazear, E., Yang, L., Sluijter, M., van Hall, T., Hansen, T. H., Yokoyama, W. M. & Fremont, D. H., Dec 1 2018, In: eLife. 7, e38667.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Cross-priming induces immunodomination in the presence of viral MHC class I inhibition

Lauron, E. J., Yang, L., Elliott, J. I., Gainey, M. D., Fremont, D. H. & Yokoyama, W. M., Feb 2018, In: PLoS pathogens. 14, 2, e1006883.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Cutting edge: Local proliferation of uterine tissue-resident NK cells during decidualization in mice

Sojka, D. K., Yang, L., Plougastel-Douglas, B., Higuchi, D. A., Anne Croy, B. & Yokoyama, W. M., Nov 1 2018, In: Journal of Immunology. 201, 9, p. 2551-2556 6 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

WDFY4 is required for cross-presentation in response to viral and tumor antigens

Theisen, D. J., Davidson, J. T., Briseño, C. G., Gargaro, M., Lauron, E. J., Wang, Q., Desai, P., Durai, V., Bagadia, P., Brickner, J. R., Beatty, W. L., Virgin, H. W., Gillanders, W. E., Mosammaparast, N., Diamond, M. S., Sibley, L. D., Yokoyama, W., Schreiber, R. D., Murphy, T. L. & Murphy, K. M., Nov 9 2018, In: Science. 362, 6415, p. 694-699 6 p.

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

2017

A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion

Patel, S. J., Zhao, G., Penna, V. R., Park, E., Lauron, E. J., Harvey, I. B., Beatty, W. L., Plougastel-Douglas, B., Poursine-Laurent, J., Fremont, D. H., Wang, D. & Yokoyama, W. M., May 1 2017, In: Journal of virology. 91, 9, e02463-16.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

CD8+ T cells prevent lethality from neonatal murine roseolovirus infection

Patel, S. J. & Yokoyama, W. M., Nov 1 2017, In: Journal of Immunology. 199, 9, p. 3212-3221 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Contribution of inhibitory receptor TIGIT to NK cell education

He, Y., Peng, H., Sun, R., Wei, H., Ljunggren, H. G., Yokoyama, W. M. & Tian, Z., Jul 2017, In: Journal of Autoimmunity. 81, p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Cutting edge: Human CD49e^- NK cells are tissue resident in the liver

Aw Yeang, H. X., Piersma, S. J., Lin, Y., Yang, L., Malkova, O. N., Miner, C., Krupnick, A. S., Chapman, W. C. & Yokoyama, W. M., Feb 15 2017, In: Journal of Immunology. 198, 4, p. 1417-1422 6 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Immunoreceptor tyrosine-based inhibitory motif–dependent functions of an MHC class I-specific NK cell receptor

Bern, M. D., Beckman, D. L., Ebihara, T., Taffner, S. M., Poursine-Laurent, J., White, J. M. & Yokoyama, W. M., Oct 3 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 40, p. E8440-E8447

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice

Almishaal, A. A., Mathur, P. D., Hillas, E., Chen, L., Zhang, A., Yang, J., Wang, Y., Yokoyama, W. M., Firpo, M. A. & Park, A. H., Aug 2017, In: PLoS pathogens. 13, 8, e1006599.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K. W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J., Bearden, A. R., Lavine, K. J., Yokoyama, W. M., Hawkins, W. G., Fields, R. C., Randolph, G. J. & DeNardo, D. G., Aug 15 2017, In: Immunity. 47, 2, p. 323-338.e6

Research output: Contribution to journal › Article › peer-review

Open Access

353 Scopus citations

2016

Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance

Arefanian, S., Schäll, D., Chang, S., Ghasemi, R., Higashikubo, R., Zheleznyak, A., Guo, Y., Yu, J., Asgharian, H., Li, W., Gelman, A. E., Kreisel, D., French, A. R., Zaher, H., Plougastel-Douglas, B., Maggi, L., Yokoyama, W., Beer-Hammer, S. & Krupnick, A. S., Dec 1 2016, In: OncoImmunology. 5, 12, e1238543.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s

Tang, L., Peng, H., Zhou, J., Chen, Y., Wei, H., Sun, R., Yokoyama, W. M. & Tian, Z., Feb 1 2016, In: Journal of Autoimmunity. 67, p. 29-35 7 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis

Demehri, S., Cunningham, T. J., Manivasagam, S., Ngo, K. H., Tuchayi, S. M., Reddy, R., Meyers, M. A., DeNardo, D. G. & Yokoyama, W. M., Apr 1 2016, In: Journal of Clinical Investigation. 126, 4, p. 1458-1470 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2015

Brief report: Chikungunya viral arthritis in the United States: A mimic of seronegative rheumatoid arthritis

Miner, J. J., Yeang, H. X. A., Fox, J. M., Taffner, S., Malkova, O. N., Oh, S. T., Kim, A. H. J., Diamond, M. S., Lenschow, D. J. & Yokoyama, W. M., May 1 2015, In: Arthritis and Rheumatology. 67, 5, p. 1214-1220 7 p.

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing

Parikh, B. A., Beckman, D. L., Patel, S. J., White, J. M. & Yokoyama, W. M., Jan 14 2015, In: PloS one. 10, 1, e0116484.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells

Parikh, B. A., Piersma, S. J., Pak-Wittel, M. A., Yang, L., Schreiber, R. D. & Yokoyama, W. M., 2015, In: PLoS pathogens. 11, 12, e1005323.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

PTEN regulates natural killer cell trafficking in vivo

Leong, J. W., Schneider, S. E., Sullivan, R. P., Parikh, B. A., Anthony, B. A., Singh, A., Jewell, B. A., Schappe, T., Wagner, J. A., Link, D. C., Yokoyama, W. M. & Fehniger, T. A., Feb 17 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. E700-E709

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Runx3 specifies lineage commitment of innate lymphoid cells

Ebihara, T., Song, C., Ryu, S. H., Plougastel-Douglas, B., Yang, L., Levanon, D., Groner, Y., Bern, M. D., Stappenbeck, T. S., Colonna, M., Egawa, T. & Yokoyama, W. M., Oct 20 2015, In: Nature immunology. 16, 11, p. 1124-1133 10 p.

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection

Rapaport, A. S., Schriewer, J., Gilfillan, S., Hembrador, E., Crump, R., Plougastel, B. F., Wang, Y., Le Friec, G., Gao, J., Cella, M., Pircher, H., Yokoyama, W. M., Buller, R. M. L. & Colonna, M., 2015, In: Immunity. 43, 6, p. 1112-1124 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

The pancreas anatomy conditions the origin and properties of resident macrophages

Calderon, B., Carrero, J. A., Ferris, S. T., Sojka, D. K., Moore, L., Epelman, S., Murphy, K. M., Yokoyama, W. M., Randolph, G. J. & Unanue, E. R., Sep 21 2015, In: Journal of Experimental Medicine. 212, 10, p. 1497-1512 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

174 Scopus citations

Tissue-resident NK cells mediate ischemic kidney injury and are not depleted by anti-asialo-GM1 antibody

Victorino, F., Sojka, D. K., Brodsky, K. S., McNamee, E. N., Masterson, J. C., Homann, D., Yokoyama, W. M., Eltzschig, H. K. & Clambey, E. T., Nov 15 2015, In: Journal of Immunology. 195, 10, p. 4973-4985 13 p.

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

2014

Chronic allergic contact dermatitis promotes skin cancer

Demehri, S., Cunningham, T. J., Hurst, E. A., Schaffer, A., Sheinbein, D. M. & Yokoyama, W. M., Nov 3 2014, In: Journal of Clinical Investigation. 124, 11, p. 5037-5041 5 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation

Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., Schilling, J. D., Schwendener, R., Sergin, I., Razani, B., Forsberg, E. C., Yokoyama, W. M., Unanue, E. R., Colonna, M., Randolph, G. J. & Mann, D. L., Jan 16 2014, In: Immunity. 40, 1, p. 91-104 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

859 Scopus citations

Ischemic neurons recruit natural killer cells that accelerate brain infarction

Gan, Y., Liu, Q., Wu, W., Yin, J. X., Bai, X. F., Shen, R., Wang, Y., Chen, J., Cava, A. L., Poursine-Laurent, J., Yokoyama, W. & Shi, F. D., Feb 18 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 7, p. 2704-2709 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

166 Scopus citations

Wayne Yokoyama

Research output

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