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Personal profile

Research interests

I am interested in the molecular mechanisms of anesthetic and lipid modulation of neural receptors and ion channels.

Areas of Clinical Interest

Coronary artery bypass grafting, prosthetic valve repair/replacement, heart transplant, lung transplant.

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Research Output

  • 392 Citations
  • 21 Article
  • 1 Comment/debate

Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts

Petroff, J. T., Tong, A., Chen, L. J., Dekoster, G. T., Khan, F., Abramson, J., Frieden, C. & Cheng, W. W. L., May 5 2020, In : Analytical Chemistry. 92, 9, p. 6622-6630 9 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

    Budelier, M. M., Cheng, W. W. L., Chen, Z. W., Bracamontes, J. R., Sugasawa, Y., Krishnan, K., Mydock-McGrane, L., Covey, D. F. & Evers, A. S., Feb 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 2, p. 128-136 9 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a Ligand-gated ion channel

    Tong, A., Hsu, F. F., Schmidpeter, P. A., Nimigean, C. M., Sharp, L., Brannigan, G. & Cheng, W. W., Nov 2019, In : eLife. 8, e50766.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Multiple functional neurosteroid binding sites on gabaa receptors

    Chen, Z. W., Bracamontes, J. R., Budelier, M. M., Germann, A. L., Shin, D. J., Kathiresan, K., Qian, M. X., Manion, B., Cheng, W. W. L., Reichert, D. E., Akk, G., Covey, D. F. & Evers, A. S., Mar 2019, In : PLoS biology. 17, 3, e3000157.

    Research output: Contribution to journalArticle

    Open Access
  • 17 Scopus citations

    Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling

    Cheng, W. W. L., Budelier, M. M., Sugasawa, Y., Bergdoll, L., Queralt-Martín, M., Rosencrans, W., Rostovtseva, T. K., Chen, Z. W., Abramson, J., Krishnan, K., Covey, D. F., Whitelegge, J. P. & Evers, A. S., Oct 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 10, p. 1269-1279 11 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations