Walter Boyle

Professor of Anesthesiology, Assistant Professor of Developmental Biology, Professor of Surgery

    • 2715 Citations
    1985 …2020

    Research output per year

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    Personal profile

    Research interests

    The laboratory has two main interests. The first concerns mechanisms of vascular failure in septic shock. Ongoing studies, utilizing isolated micro-vessels and intact animal models, are directed at the identification and use of specific inhibitors for the phosphatase which degrades phosphorylated myosin as a potential therapeutic strategy to reverse the excessive vasodilation and catecholamine resistance that occur in this condition. The second focus is identification of novel biomarkers of organ injury in the urine proteome. Ongoing studies utilizing immunoassay and mass spectrometric techniques, being conducted in critically ill patients with myocardial injury and patients undergoing a timed myocardial infarction (percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy), are directed at the discovery of urinary biomarkers that can be used to identify and follow acute cardiac injury non-invasively.

    Areas of Clinical Interest

    Anesthesiology, critical care medicine

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    Research Output

    • 2715 Citations
    • 56 Article
    • 5 Letter

    Dill extract induces elastic fiber neosynthesis and functional improvement in the ascending aorta of aged mice with reversal of age-dependent cardiac hypertrophy and involvement of lysyl oxidase-like-1

    Fhayli, W., Boëté, Q., Kihal, N., Cenizo, V., Sommer, P., Boyle, W. A., Jacob, M. P. & Faury, G., Feb 2020, In : Biomolecules. 10, 2, 173.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Decision-making skills improve with critical care training: Using simulation to measure progress

    Murray, D. J., Boyle, W. A., Beyatte, M. B., Knittel, J. G., Kerby, P. W., Woodhouse, J. & Boulet, J. R., Oct 2018, In : Journal of Critical Care. 47, p. 133-138 6 p.

    Research output: Contribution to journalArticle

  • Simulation-Based Assessment of Critical Care "Front-Line" Providers

    Boyle, W. A., Murray, D. J., Beyatte, M. B., Knittel, J. G., Kerby, P. W., Woodhouse, J. & Boulet, J. R., Jun 1 2018, In : Critical care medicine. 46, 6, p. e516-e522

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Clinical effectiveness of a sedation protocol minimizing benzodiazepine infusions and favoring early dexmedetomidine: A before-after study

    Skrupky, L. P., Drewry, A. M., Wessman, B., Field, R. R., Fagley, R. E., Varghese, L., Lieu, A., Olatunde, J., Micek, S. T., Kollef, M. H. & Boyle, W. A., Apr 2 2015, In : Critical Care. 19, 1, 136.

    Research output: Contribution to journalArticle

    Open Access
  • 12 Scopus citations