Research in the Gonzalez-Perez lab is aimed to understand the molecular and cellular mechanisms whereby membrane proteins, particularly ion channels and receptors, mediate host defense in neural and epithelial cells in the contexts of homeostasis and inflammation. Our research is currently focused on studying the role of the calcium and voltage-activated potassium channels (BK) in intestinal epithelial (patho)physiology, and in neuroinflammation. We employ an approach that combines the use of several KO mouse models, mouse or human organoids, and heterologous expression system to perform patch clamp electrophysiology, molecular biology, biochemical methods, live-tissue imaging, and behavioral assays. At present, the lab research program consists of two lines seeking to understand:

1) The protective effects of BK channels containing the regulatory subunit LRRC26 against intestinal inflammation.
2) The contribution of BK channels to opioid-induced hyperalgesia and chronic pain.