Research output per year
Research output per year
Personal profile
Research interests
My research interests focus on the impact of CD36 deficiency on inflammation and lipid trafficking. CD36 deletion disrupts immune cell trafficking to lymph nodes and results in chronic inflammation driven by neutrophils. Humans with partial CD36 deficiency, which associates with abnormal chylomicron clearance, have more activated neutrophils in the circulation, suggesting subclinical inflammation. CD36 deletion affects the lymphatic system, rerouting more of intestinal chylomicrons to the liver, promoting hepatic steatosis and early signs of fibrosis.
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Editorial: The Role of the Lymphatic System in Lipid and Energy Metabolism, and Immune Homeostasis During Obesity and Diabetes
Cifarelli, V., Chen, H. & Scallan, J. P., Mar 4 2021, In: Frontiers in Physiology. 12, 652461.Research output: Contribution to journal › Editorial
Open Access2 Scopus citations -
Lipolytic enzymes and free fatty acids at the endothelial interface
Goldberg, I. J., Cabodevilla, A. G., Samovski, D., Cifarelli, V., Basu, D. & Abumrad, N. A., Jul 2021, In: Atherosclerosis. 329, p. 1-8 8 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
Cifarelli, V., Appak-Baskoy, S., Peche, V. S., Kluzak, A., Shew, T., Narendran, R., Pietka, K. M., Cella, M., Walls, C. W., Czepielewski, R., Ivanov, S., Randolph, G. J., Augustin, H. G. & Abumrad, N. A., Dec 2021, In: Nature communications. 12, 1, 3350.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity
Cifarelli, V., Beeman, S. C., Smith, G. I., Yoshino, J., Morozov, D., Beals, J. W., Kayser, B. D., Watrous, J. D., Jain, M., Patterson, B. W. & Klein, S., Dec 1 2020, In: Journal of Clinical Investigation. 130, 12, p. 6688-6699 12 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
The Intestinal Lymphatic System: Functions and Metabolic Implications
Cifarelli, V. & Eichmann, A., 2019, In: CMGH. 7, 3, p. 503-513 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access42 Scopus citations