• 2381 Citations
1979 …2020

Research output per year

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Personal profile

Research interests

Molecular imaging enables visualization, characterization, and measurement of biological events (specifically relevant to diagnosis and therapeutic interventions) at both molecular and cellular levels in vivo. In the 21st century, molecular imaging is envisioned to play a pivotal role in drug development (determining target-sensitivity, -specificity, and dose efficacy), diagnosis and staging of disease states, identifying new biomarkers, and improving disease management (early diagnosis, new therapeutics, improving prognosis, and patient stratification). Our laboratory works at the interface of synthetic chemistry (organic and inorganic), medicinal chemistry (radiological molecular imaging), and biology. We design and develop molecular probes potentially capable of interrogating important biochemical pathways across multiple disciplines via interdisciplinary research. Some of the active research areas within our laboratory include the design and synthesis of small organic molecules and peptides for diagnosis of diseases, to understand protein-protein interactions via imaging of reporter gene expression in vivo, and employ these reagents to study biological mechanism(s). Additionally, our research interests include design and development of SPECT and PET tracers for probing the role of transporter-mediated drug resistance pathways in cancer biology, the blood-brain barrier, neurodegenerative diseases (Alzheimer’s Disease), and cardiovascular diseases (myocardial perfusion imaging).

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Research Output

  • 2381 Citations
  • 64 Article
  • 6 Review article
  • 1 Chapter
  • 1 Editorial

Fluselenamyl: Evaluation of radiation dosimetry in mice and pharmacokinetics in brains of non-human primate

Sundaram, G. S. M., Jones, L., Zhou, Y., Laforest, R. & Sharma, V., Mar 1 2020, In : Nuclear Medicine and Biology. 82-83, p. 33-40 8 p.

Research output: Contribution to journalArticle

  • PET Radiopharmaceuticals for Imaging Chemotherapy-Induced Cardiotoxicity

    Sivapackiam, J., Sharma, M., Schindler, T. H. & Sharma, V., Aug 1 2020, In : Current Cardiology Reports. 22, 8, 62.

    Research output: Contribution to journalReview article

    Open Access
  • 68Ga-Galmydar: A PET imaging tracer for noninvasive detection of Doxorubicin-induced cardiotoxicity

    Sivapackiam, J., Kabra, S., Speidel, S., Sharma, M., Laforest, R., Salter, A., Rettig, M. P. & Sharma, V., May 2019, In : PloS one. 14, 5, e0215579.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    68 Ga-Galmydar: Biodistribution and radiation dosimetry studies in rodents

    Sivapackiam, J., Laforest, R. & Sharma, V., Apr 2018, In : Nuclear Medicine and Biology. 59, p. 29-35 7 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Live-cell fluorescence imaging: Assessment of thioflavin T uptake in human epidermal carcinoma cells

    Sundaram, G. S. M., Binz, K., Sharma, V., Yeung, M. & Sharma, V., Jan 1 2018, In : MedChemComm. 9, 6, p. 946-950 5 p.

    Research output: Contribution to journalArticle