Todd Druley

Research Output

Research Output per year

1997 2020

• 2585 Citations
• 54 Article
• 2 Letter
• 2 Review article
• 1 Book
• 2 More
  • 1 Foreword/postscript
  • 1 Comment/debate

Research Output per year

Research Output per year

Search results

• Article

  Adaptation of the targeted capture Methyl-Seq platform for the mouse genome identifies novel tissue-specific DNA methylation patterns of genes involved in neurodevelopment

  Hing, B., Ramos, E., Braun, P., McKane, M., Jancic, D., Tamashiro, K. L. K., Lee, R. S., Michaelson, J. J., Druley, T. E. & Potash, J. B., Jan 1 2015, In: Epigenetics. 10, 7, p. 581-596 16 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Methylation
  • Genome
  • Liver
  • hydrogen sulfite
  • Genes
  14 Scopus citations

• Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites

  Uli, N., Michelen-Gomez, E., Ramos, E. I. & Druley, T. E., Sep 2018, In: PloS one. 13, 9, e0203147.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methylation
  • Estrogen Receptor alpha
  • estrogen receptors
  • methylation
  • Genes
  1 Scopus citations

• Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity

  Druley, T. E., Stein, W. D. & Roninson, I. B., Apr 10 2001, In: Biochemistry. 40, 14, p. 4312-4322 11 p.

  Research output: Contribution to journal › Article › peer-review

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Nucleotides
  • Adenosine Triphosphate
  • Vinblastine
  • Adenosine Diphosphate
  56 Scopus citations

• Cancer therapy shapes the fitness landscape of clonal hematopoiesis

  Bolton, K. L., Ptashkin, R. N., Gao, T., Braunstein, L., Devlin, S. M., Kelly, D., Patel, M., Berthon, A., Syed, A., Yabe, M., Coombs, C. C., Caltabellotta, N. M., Walsh, M., Offit, K., Stadler, Z., Mandelker, D., Schulman, J., Patel, A., Philip, J., Bernard, E. & 44 others, Gundem, G., Ossa, J. E. A., Levine, M., Martinez, J. S. M., Farnoud, N., Glodzik, D., Li, S., Robson, M. E., Lee, C., Pharoah, P. D. P., Stopsack, K. H., Spitzer, B., Mantha, S., Fagin, J., Boucai, L., Gibson, C. J., Ebert, B. L., Young, A. L., Druley, T., Takahashi, K., Gillis, N., Ball, M., Padron, E., Hyman, D. M., Baselga, J., Norton, L., Gardos, S., Klimek, V. M., Scher, H., Bajorin, D., Paraiso, E., Benayed, R., Arcila, M. E., Ladanyi, M., Solit, D. B., Berger, M. F., Tallman, M., Garcia-Closas, M., Chatterjee, N., Diaz, L. A., Levine, R. L., Morton, L. M., Zehir, A. & Papaemmanuil, E., Nov 1 2020, In: Nature Genetics. 52, 11, p. 1219-1226 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoiesis
  • Mutation
  • Clone Cells
  • DNA Damage
  • Neoplasms

• Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study

  Druley, T. E., Wang, L., Lin, S. J., Lee, J. H., Zhang, Q., Daw, E. W., Abel, H. J., Chasnoff, S. E., Ramos, E. I., Levinson, B. T., Thyagarajan, B., Newman, A. B., Christensen, K., Mayeux, R. & Province, M. A., Apr 9 2016, In: BMC Geriatrics. 16, 1, 80.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Healthy Aging
  • Pedigree
  • Phenotype
  • Genes
  • Telomere
  15 Scopus citations

• Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease

  Matkovich, S. J., Van Booven, D. J., Hindes, A., Kang, M. Y., Druley, T. E., Vallania, F. L. M., Mitra, R. D., Reilly, M. P., Cappola, T. P. & Dorn, G. W., Jan 4 2010, In: Journal of Clinical Investigation. 120, 1, p. 280-289 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cardiomyopathies
  • Single Nucleotide Polymorphism
  • Genes
  • Systolic Heart Failure
  • Heart Failure
  49 Scopus citations

• Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

  Young, A. L., Challen, G. A., Birmann, B. M. & Druley, T. E., Aug 22 2016, In: Nature communications. 7, 12484.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hematopoiesis
  • mutations
  • Hematopoiesis
  • sequencing
  • Stem cells
  226 Scopus citations

• Clonal hematopoiesis and risk of acute myeloid leukemia

  Young, A. L., Spencer Tong, R., Birmann, B. M. & Druley, T. E., 2019, In: Haematologica. 104, 12, p. 2410-2417 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoiesis
  • Acute Myeloid Leukemia
  • Mutation
  • Clone Cells
  • Alleles
  16 Scopus citations

• Congenital neurodevelopmental anomalies in pediatric and young adult cancer

  Wong-Siegel, J. R., Johnson, K. J., Gettinger, K., Cousins, N., McAmis, N., Zamarione, A. & Druley, T. E., Oct 2017, In: American Journal of Medical Genetics, Part A. 173, 10, p. 2670-2679 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Young Adult
  • Pediatrics
  • Neoplasms
  • Child
  • Infant Death
  4 Scopus citations

• Detection of rare genomic variants from pooled sequencing using SPLINTER

  Vallania, F., Ramos, E., Cresci, S., Mitra, R. D. & Druley, T. E., Jun 23 2012, In: Journal of Visualized Experiments. 64, p. 1-9 9 p., e3943.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA
  • Genetic Variation
  • Genes
  • Alleles
  • Genome
  6 Scopus citations

• Distal chromosome 16p11.2 duplications containing SH2B1 in patients with scoliosis

  Sadler, B., Haller, G., Antunes, L., Bledsoe, X., Morcuende, J., Giampietro, P., Raggio, C., Miller, N., Kidane, Y., Wise, C. A., Amarillo, I., Walton, N., Seeley, M., Johnson, D., Jenkins, C., Jenkins, T., Oetjens, M., Tong, R. S., Druley, T. E., Dobbs, M. B. & 1 others, Gurnett, C. A., Jul 1 2019, In: Journal of Medical Genetics. 56, 7, p. 427-433 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromosome Duplication
  • Scoliosis
  • Chromosomes
  • Exome
  • Electronic Health Records
  3 Scopus citations

• Dnmt3a regulates T-cell development and suppresses T-ALL transformation

  Kramer, A. C., Kothari, A., Wilson, W. C., Celik, H., Nikitas, J., Mallaney, C., Ostrander, E. L., Eultgen, E., Martens, A., Valentine, M. C., Young, A. L., Druley, T. E., Figueroa, M. E., Zhang, B. & Challen, G. A., Nov 1 2017, In: Leukemia. 31, 11, p. 2479-2490 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • T-Lymphocytes
  • Methyltransferases
  • Genetic Models
  • Precision Medicine
  15 Scopus citations

• Early outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI

  Druley, T. E., Hayashi, R., Mansur, D. B., Zhang, Q., Barnes, Y., Trinkaus, K., Witty, S., Thomas, T., Klein, E. E., DiPersio, J. F., Adkins, D. & Shenoy, S., 2009, In: Bone Marrow Transplantation. 43, 4, p. 307-314 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematologic Neoplasms
  • Unrelated Donors
  • Pediatrics
  • Tissue Donors
  • Child
  8 Scopus citations

• Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation

  Wong, W. H., Bhatt, S., Trinkaus, K., Pusic, I., Elliott, K., Mahajan, N., Wan, F., Switzer, G. E., Confer, D. L., DiPersio, J., Pulsipher, M. A., Shah, N. N., Sees, J., Bystry, A., Blundell, J. R., Shaw, B. E. & Druley, T. E., Jan 15 2020, In: Science translational medicine. 12, 526, eaax6249.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoietic Stem Cell Transplantation
  • Clone Cells
  • Tissue Donors
  • Mutation
  • Hematopoietic Stem Cells
  5 Scopus citations

• Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring

  Crowgey, E. L., Mahajan, N., Wong, W. H., Gopalakrishnapillai, A., Barwe, S. P., Kolb, E. A. & Druley, T. E., Mar 4 2020, In: BMC Medical Genomics. 13, 1, 32.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Residual Neoplasm
  • Gene Fusion
  • Leukemia
  • RNA Sequence Analysis
  • Limit of Detection
  1 Scopus citations

• Excess congenital non-synonymous variation in leukemia-associated genes in MLL- Infant leukemia: A Children's Oncology Group report

  Valentine, M. C., Linabery, A. M., Chasnoff, S., Hughes, A. E. O., Mallaney, C., Sanchez, N., Giacalone, J., Heerema, N. A., Hilden, J. M., Spector, L. G., Ross, J. A. & Druley, T. E., Jun 2014, In: Leukemia. 28, 6, p. 1235-1241 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukemia
  • Child
  • Genes
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Acute Myeloid Leukemia
  18 Scopus citations

• Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly

  Ramos, E. I., Bien-Willner, G. A., Li, J., Hughes, A. E. O., Giacalone, J., Chasnoff, S., Kulkarni, S., Parmacek, M., Cole, F. S. & Druley, T. E., May 2014, In: Clinical Genetics. 85, 5, p. 423-432 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Serum Response Factor
  • Microcephaly
  • Genetic Variation
  • Transcription Factors
  • Brain
  5 Scopus citations

• Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: The long life family study

  Lee, J. H., Cheng, R., Honig, L. S., Feitosa, M., Kammerer, C. M., Kang, M. S., Schupf, N., Lin, S. J., Sanders, J. L., Bae, H., Druley, T., Perls, T., Christensen, K., Province, M. & Mayeux, R., 2013, In: Frontiers in Genetics. 4, JAN, Article 310.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere
  • Genome-Wide Association Study
  • Leukocytes
  • telomerase RNA
  • Single Nucleotide Polymorphism
  38 Scopus citations

• Germline sequencing identifies rare variants in finnish subjects with familial germ cell tumors

  Crowgey, E. L., Soini, T., Shah, N., Pauniaho, S. L., Lahdenne, P., Wilson, D. B., Heikinheimo, M. & Druley, T. E., 2020, In: Application of Clinical Genetics. 13, p. 127-137 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Germ Cell and Embryonal Neoplasms
  • Teratoma
  • Endodermal Sinus Tumor
  • Genes
  • De Lange Syndrome

• Herbaspirillum species bacteremia in a pediatric oncology patient

  Ziga, E. D., Druley, T. & Burnham, C. A. D., Nov 2010, In: Journal of clinical microbiology. 48, 11, p. 4320-4321 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Herbaspirillum
  • Bacteremia
  • Pediatrics
  • Soil
  • Hematopoietic Stem Cells
  23 Scopus citations

• High-throughput discovery of rare insertions and deletions in large cohorts

  Vallania, F. L. M., Druley, T. E., Ramos, E., Wang, J., Borecki, I., Province, M. & Mitra, R. D., Dec 2010, In: Genome research. 20, 12, p. 1711-1718 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sensitivity and Specificity
  • Gene Library
  • DNA Sequence Analysis
  • Rare Diseases
  • Inborn Genetic Diseases
  43 Scopus citations

• Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4

  Philip Creamer, J., Dege, C., Ren, Q., Ho, J. T. K., Valentine, M. C., Druley, T. E. & Sturgeon, C. M., Jun 1 2017, In: Blood. 129, 22, p. 2988-2992 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells
  • Pluripotent Stem Cells
  • Mesoderm
  • Specifications
  • Gene expression
  7 Scopus citations

• Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity

  Rajan, V., Melong, N., Wong, W. H., King, B., Spencer Tong, R., Mahajan, N., Gaston, D., Lund, T., Rittenberg, D., Dellaire, G., Campbell, C. J. V., Druley, T. & Berman, J. N., Oct 2020, In: Haematologica. 105, 10, p. 2391-2399 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zebrafish
  • Hematopoietic Stem Cells
  • Acute Myeloid Leukemia
  • Cell Survival
  • Leukemia

• Integrated analysis of germline and somatic variants in ovarian cancer

  Kanchi, K. L., Johnson, K. J., Lu, C., McLellan, M. D., Leiserson, M. D. M., Wendl, M., Zhang, Q., Koboldt, D. C., Xie, M., Kandoth, C., McMichael, J. F., Wyczalkowski, M. A., Larson, D. E., Schmidt, H. K., Miller, C., Fulton, R., Spellman, P. T., Mardis, E. R., Druley, T., Graubert, T. A. & 4 others, Goodfellow, P. J., Raphael, B. J., Wilson, R. K. & Ding, L., Jan 22 2014, In: Nature communications. 5, 3156.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cancer
  • Ovarian Neoplasms
  • Genes
  • Exome
  • Loss of Heterozygosity
  152 Scopus citations

• Late toxicity of a novel allogeneic stem cell transplant using single fraction total body irradiation for hematologic malignancies in children

  Madden, L. M., Ngwube, A. I., Shenoy, S., Druley, T. E. & Hayashi, R. J., Mar 6 2015, In: Journal of Pediatric Hematology/Oncology. 37, 2, p. e94-e101

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole-Body Irradiation
  • Allogeneic Cells
  • Hematologic Neoplasms
  • Stem Cells
  • Transplants
  4 Scopus citations

• Multiplexed direct genomic selection (MDiGS): A pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection

  Alvarado, D. M., Yang, P., Druley, T. E., Lovett, M. & Gurnett, C. A., 2014, In: Nucleic acids research. 42, 10, p. e82

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacterial Artificial Chromosomes
  • Single Nucleotide Polymorphism
  • Costs and Cost Analysis
  • Chromosome Duplication
  • Clubfoot
  8 Scopus citations

• Myosin binding protein C1: A novel gene for autosomal dominant distal arthrogryposis type 1

  Gurnett, C. A., Desruisseau, D. M., McCall, K., Choi, R., Meyer, Z. I., Talerico, M., Miller, S. E., Ju, J. S., Pestronk, A., Connolly, A. M., Druley, T. E., Weihl, C. C. & Dobbs, M. B., Jan 2 2010, In: Human molecular genetics. 19, 7, p. 1165-1173 9 p., ddp587.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Distal type 1 Arthrogryposis multiplex congenita
  • Dominant Genes
  • Myosins
  • Carrier Proteins
  • Hypertrophic Cardiomyopathy
  64 Scopus citations

• NF1 glioblastoma clonal profiling reveals KMT2B mutations as potential somatic oncogenic events

  Wong, W. H., Junck, L., Druley, T. E. & Gutmann, D. H., Dec 10 2019, In: Neurology. 93, 24, p. 1067-1069 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurofibromatosis 1
  • Glioblastoma
  • Mutation
  • Autopsy
  • Septum Pellucidum
  1 Scopus citations

• Nomenclature and definition in asymmetric regional body overgrowth

  Kalish, J. M., Biesecker, L. G., Brioude, F., Deardorff, M. A., Di Cesare-Merlone, A., Druley, T., Ferrero, G. B., Lapunzina, P., Larizza, L., Maas, S., Macchiaiolo, M., Maher, E. R., Maitz, S., Martinez-Agosto, J. A., Mussa, A., Robinson, P., Russo, S., Selicorni, A. & Hennekam, R. C., Jul 2017, In: American Journal of Medical Genetics, Part A. 173, 7, p. 1735-1738 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Isolated Hemihyperplasia
  • Terminology
  15 Scopus citations

• Novel mutation in AIRE gene with autoimmune polyendocrine syndrome type 1

  Fardi Golyan, F., Ghaemi, N., Abbaszadegan, M. R., Dehghan Manshadi, S. H., Vakili, R., Druley, T. E., Rahimi, H. R. & Ghahraman, M., Nov 2019, In: Immunobiology. 224, 6, p. 728-733 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Type 1 Autoimmune polyendocrinopathy syndrome
  • Regulator Genes
  • Mutation
  • Exons
  • Genes

• Parental Age and Risk of Infant Leukaemia: A Pooled Analysis

  Marcotte, E. L., Druley, T. E., Johnson, K. J., Richardson, M., von Behren, J., Mueller, B. A., Carozza, S., McLaughlin, C., Chow, E. J., Reynolds, P. & Spector, L. G., Nov 2017, In: Paediatric and Perinatal Epidemiology. 31, 6, p. 563-572 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leukemia
  • Parents
  • Paternal Age
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Odds Ratio
  7 Scopus citations

• P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity

  Mechetner, E. B., Schott, B., Morse, B. S., Stein, W. D., Druley, T., Davis, K. A., Tsuruo, T. & Roninson, I. B., Nov 25 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 24, p. 12908-12913 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Nucleotides
  • Adenosine Triphosphate
  • ATP-Binding Cassette Transporters
  • Adenosine Triphosphatases
  161 Scopus citations

• P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation

  Druley, T. E., Stein, W. D., Ruth, A. & Roninson, I. B., Apr 10 2001, In: Biochemistry. 40, 14, p. 4323-4331 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Conformations
  • Colchicine
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Cells
  • Vinblastine
  29 Scopus citations

• Pooled sequencing of candidate genes implicates rare variants in the development of asthma following severe RSV bronchiolitis in infancy

  Torgerson, D. G., Giri, T., Druley, T. E., Zheng, J., Huntsman, S., Seibold, M. A., Young, A. L., Schweiger, T., Yin-Declue, H., Sajol, G. D., Schechtman, K. B., Hernandez, R. D., Randolph, A. G., Bacharier, L. B. & Castro, M., Nov 1 2015, In: PloS one. 10, 11, e0142649.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • bronchiolitis
  • Respiratory syncytial virus
  • Bronchiolitis
  • infancy
  • Respiratory Syncytial Viruses
  6 Scopus citations

• Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing

  Ramos, E., Levinson, B. T., Chasnoff, S., Hughes, A., Young, A. L., Thornton, K., Li, A., Vallania, F. L. M., Province, M. & Druley, T. E., Dec 6 2012, In: BMC genomics. 13, 1, 683.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exome
  • DNA
  • Population
  • Sonication
  • Costs and Cost Analysis
  15 Scopus citations

• Prevalence of clinically actionable disease variants in exceptionally long-lived families

  Carlson, P., Wojczynski, M. K., Druley, T., Lee, J. H., Zmuda, J. M. & Thyagarajan, B., Apr 10 2020, In: BMC Medical Genomics. 13, 1, 61.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Penetrance
  • Gene Frequency
  • Databases
  • Mutation
  • Genes

• Quantification of rare allelic variants from pooled genomic DNA

  Druley, T. E., Vallania, F. L. M., Wegner, D. J., Varley, K. E., Knowles, O. L., Bonds, J. A., Robison, S. W., Doniger, S. W., Hamvas, A., Cole, F. S., Fay, J. C. & Mitra, R. D., 2009, In: Nature Methods. 6, 4, p. 263-265 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Polymorphism
  • Single Nucleotide Polymorphism
  • Nucleotides
  • DNA
  • Genes
  117 Scopus citations

• Rare event detection using error-corrected DNA and RNA sequencing

  Wong, W. H., Spencer Tong, R., Young, A. L. & Druley, T. E., Aug 3 2018, In: Journal of Visualized Experiments. 2018, 138, e57509.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA
  • RNA Sequence Analysis
  • Error detection
  • DNA
  • DNA Sequence Analysis
  6 Scopus citations

• Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence

  Haller, G., Druley, T., Vallania, F. L., Mitra, R. D., Li, P., Akk, G., Steinbach, J. H., Breslau, N., Johnson, E., Hatsukami, D., Stitzel, J., Bierut, L. J. & Goate, A. M., Feb 2012, In: Human molecular genetics. 21, 3, p. 647-655 9 p., ddr498.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tobacco Use Disorder
  • Nicotine
  • African Americans
  • Smokers
  • Odds Ratio
  45 Scopus citations

• Recommendations for surveillance for children with leukemia-predisposing conditions

  Porter, C. C., Druley, T. E., Erez, A., Kuiper, R. P., Onel, K., Schiffman, J. D., Schneider, K. W., Scollon, S. R., Scott, H. S., Strong, L. C., Walsh, M. F. & Nichols, K. E., Jun 1 2017, In: Clinical Cancer Research. 23, 11, p. e14-e22

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukemia
  • Child
  • Li-Fraumeni Syndrome
  • Blood Cell Count
  • Myelodysplastic Syndromes
  34 Scopus citations

• RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts

  Azar, C., Valentine, M., Trausch-Azar, J., Druley, T., Nelson, D. M. & Schwartz, A. L., Dec 1 2018, In: Scientific reports. 8, 1, 5142.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Trophoblasts
  • RNA
  • Proteins
  • Placentation
  • Gene Expression
  10 Scopus citations

• Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

  Wong, T. N., Ramsingh, G., Young, A. L., Miller, C. A., Touma, W., Welch, J. S., Lamprecht, T. L., Shen, D., Hundal, J., Fulton, R. S., Heath, S., Baty, J. D., Klco, J. M., Ding, L., Mardis, E. R., Westervelt, P., Dipersio, J. F., Walter, M. J., Graubert, T. A., Ley, T. J. & 3 others, Druley, T. E., Link, D. C. & Wilson, R. K., Feb 26 2015, In: Nature. 518, 7540, p. 552-555 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Myeloid Leukemia
  • Mutation
  • Hematopoietic Stem Cells
  • Myelodysplastic Syndromes
  • Drug Therapy
  363 Scopus citations

• Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease

  Schuettpelz, L. G., Behrens, D., Goldsmith, M. I. & Druley, T. E., Nov 1 2009, In: Journal of Pediatric Hematology/Oncology. 31, 11, p. 870-872 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Ceftriaxone
  • Sickle Cell Anemia
  • Hemolysis
  • Brain Ischemia
  • Child
  7 Scopus citations

• Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome

  Wambach, J. A., Wegner, D. J., DePass, K., Heins, H., Druley, T. E., Mitra, R. D., An, P., Zhang, Q., Nogee, L. M., Cole, F. S. & Hamvas, A., Dec 2012, In: Pediatrics. 130, 6, p. e1575-e1582

  Research output: Contribution to journal › Article › peer-review

  • Newborn Respiratory Distress Syndrome
  • Mutation
  • Pyridinolcarbamate
  • Population
  • Pulmonary Surfactants
  55 Scopus citations

• Special Therapy and Psychosocial Needs Identified in a Multidisciplinary Cancer Predisposition Syndrome Clinic

  Groves, A. P., Gettinger, K., Druley, T. E., Kozel, B. A., Shinawi, M., Mohrmann, C., Henry, J., Jacobi, C., Trinkaus, K. & Hayashi, R. J., Mar 1 2019, In: Journal of Pediatric Hematology/Oncology. 41, 2, p. 133-136 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasms
  • Therapeutics
  • Speech Therapy
  • Occupational Therapy
  • Registries

• Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples

  Barwe, S. P., Gopalakrisnapillai, A., Mahajan, N., Druley, T. E., Kolb, E. A. & Crowgey, E. L., Mar 2020, In: Genomics and Informatics. 18, 1, e6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • leukemia
  • pediatrics
  • RNA
  • Heterografts
  • Leukemia

• Surveillance recommendations for children with overgrowth syndromes and predisposition to wilms tumors and hepatoblastoma

  Kalish, J. M., Doros, L., Helman, L. J., Hennekam, R. C., Kuiper, R. P., Maas, S. M., Maher, E. R., Nichols, K. E., Plon, S. E., Porter, C. C., Rednam, S., Schultz, K. A. P., States, L. J., Tomlinson, G. E., Zelley, K. & Druley, T. E., Jul 1 2017, In: Clinical Cancer Research. 23, 13, p. e115-e122

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepatoblastoma
  • Wilms Tumor
  • Child
  • Parturition
  • Neoplasms
  51 Scopus citations

• Synonymous ABCA3 variants do not increase risk for neonatal respiratory distress syndrome

  Wambach, J. A., Wegner, D. J., Heins, H. B., Druley, T. E., Mitra, R. D., Hamvas, A. & Cole, F. S., Jun 2014, In: Journal of Pediatrics. 164, 6, p. 1316-1321.e3

  Research output: Contribution to journal › Article › peer-review

  • Newborn Respiratory Distress Syndrome
  • Adenosine Triphosphate
  • Premature Infants
  • Silent Mutation
  • Computer Simulation
  5 Scopus citations

• The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients

  Warrington, N. M., Sun, T., Luo, J., McKinstry, R. C., Parkin, P. C., Ganzhorn, S., Spoljaric, D., Albers, A. C., Merkelson, A., Stewart, D. R., Stevenson, D. A., Viskochil, D., Druley, T. E., Forys, J. T., Reilly, K. M., Fisher, M. J., Tabori, U., Allen, J. C., Schiffman, J. D., Gutmann, D. H. & 1 others, Rubin, J. B., Jan 1 2015, In: Cancer research. 75, 1, p. 16-21 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurofibromatosis 1
  • Cyclic AMP
  • Glioma
  • Adenylyl Cyclases
  • Neurofibromatoses
  30 Scopus citations

• The evolutionary dynamics and fitness landscape of clonal hematopoiesis

  Watson, C. J., Papula, A. L., Poon, G. Y. P., Wong, W. H., Young, A. L., Druley, T. E., Fisher, D. S. & Blundell, J. R., Mar 27 2020, In: Science. 367, 6485, p. 1449-1454 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoiesis
  • Mutation
  • Genetic Fitness
  • Genetic Drift
  • Hematopoietic Stem Cells
  19 Scopus citations