Research output per year
Research output per year
Personal profile
Research interests
We are interested in characterizing the impact of rare genetic variation - SNPs, INDELs, CNVs, methylation differences - in pediatric cancer. We adapt the latest genomic technologies and bioinformatic algorithms to perform population-based research. From the DNA sequencing results, we will develop in vitro systems to study the functional impact of genetic variation.
Areas of Clinical Interest
Pediatric cancer, pediatric blood disorders, pediatric brain tumor, pediatric oncology, pediatrics; cancer predisposition
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A non-stop identity complex (Nic) supervises enterocyte identity and protects from premature aging
Neta-Erez, Israitel, L., Bitman-Lotan, E., Wong, W. H., Raz, G., Cornelio-Parra, D. V., Danial, S., Brodsly, NA. F., Belova, E., Maksimenko, O., Georgiev, P., Druley, T., Mohan, R. & Orian, A., Feb 2021, In: eLife. 10, p. 1-52 52 p., e62312.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification
Maurya, S., Yang, W., Tamai, M., Zhang, Q., Erdmann-Gilmore, P., Bystry, A., Martins Rodrigues, F., Valentine, M. C., Wong, W. H., Townsend, R. & Druley, T. E., 2021, (Accepted/In press) In: Epigenetics.Research output: Contribution to journal › Article › peer-review
Open Access -
Cancer therapy shapes the fitness landscape of clonal hematopoiesis
Bolton, K. L., Ptashkin, R. N., Gao, T., Braunstein, L., Devlin, S. M., Kelly, D., Patel, M., Berthon, A., Syed, A., Yabe, M., Coombs, C. C., Caltabellotta, N. M., Walsh, M., Offit, K., Stadler, Z., Mandelker, D., Schulman, J., Patel, A., Philip, J., Bernard, E. & 44 others, , Nov 1 2020, In: Nature Genetics. 52, 11, p. 1219-1226 8 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation
Wong, W. H., Bhatt, S., Trinkaus, K., Pusic, I., Elliott, K., Mahajan, N., Wan, F., Switzer, G. E., Confer, D. L., DiPersio, J., Pulsipher, M. A., Shah, N. N., Sees, J., Bystry, A., Blundell, J. R., Shaw, B. E. & Druley, T. E., Jan 15 2020, In: Science translational medicine. 12, 526, eaax6249.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring
Crowgey, E. L., Mahajan, N., Wong, W. H., Gopalakrishnapillai, A., Barwe, S. P., Kolb, E. A. & Druley, T. E., Mar 4 2020, In: BMC Medical Genomics. 13, 1, 32.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations