Personal profile
Research interests
Our research is to understand the evolution and adaption of human regulatory networks, with a focus on the impact of these processes on human health and disease. In particular, we investigate the evolutionary model of mobile elements (or transposable elements) and their roles in basic biology and cancer, including their genetic and epigenetic regulation.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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An integrated view of the structure and function of the human 4D nucleome
Dekker, J., Oksuz, B. A., Zhang, Y., Wang, Y., Minsk, M. K., Kuang, S., Yang, L., Gibcus, J. H., Krietenstein, N., Rando, O. J., Xu, J., Janssens, D. H., Henikoff, S., Kukalev, A., Andréa, W., Winick-Ng, W., Kempfer, R., Pombo, A., Yu, M. & Kumar, P. & 70 others, , Jan 15 2026, In: Nature. 649, 8097, p. 759-776 18 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Distinct contributions of Etv2+ and Flk1+ progenitors to endothelial, hematopoietic, and cardiac lineages
Alleyne, D., Kim, M., Wu, J., Kwon, Y., Kim, Y. R., Kabir, A. U., Ishahak, M., Millman, J. R., Fan, C., Lee, H. J., Krchma, K., Xing, X., Lavine, K., Wang, T. & Choi, K., Jan 27 2026, In: Cell Reports. 45, 1, p. 116733 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model
DeSouza, P. A., Ishahak, M., Qu, X., McCornack, C., Annamalai, D., Mao, D. D., Vangipurapu, R., Fu, Y., Vessoni, A. T., Cleary, R. T., Han, R. H., Augsornworawat, P., Woodiwiss, T., Agovino, D., Sizemore, B., Kline, J., Borhani-Haghighi, M., Chen, H., Pugazenthi, S. & Yano, H. & 4 others, , Dec 2026, In: Nature communications. 17, 1, 31.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Unmasked: transposable elements as drivers and targets in cancer
Grinwald, M. F., Saintilnord, W. N. & Wang, T., Jan 2026, In: Trends in Genetics. 42, 1, p. 30-45 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Charting the regulatory landscape of TP53 on transposable elements in cancer
Qu, X., Liang, Y., McCornack, C., Xing, X., Schmidt, H., Tomlinson, C., Fronick, C., Belter, E. A., Macias-Velasco, J. F. & Wang, T., Jun 2025, In: Genome research. 35, 6, p. 1456-1471 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations