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Timothy Miller

Clayson Professor of Neurology

    • 9449 Citations
    1984 …2020

    Research output per year

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    Personal profile

    Research interests

    My research program focuses on: 1. Gene down regulation strategies (RNAi and antisense oligonucleotides) to understand disease pathogenesis and provide novel therapies for neurodegenerative diseases, in particular amyotrophic lateral sclerosis (ALS) 2. How dysfunction of mitochondria causes loss of motor neurons.

    Areas of Clinical Interest

    ALS and neurological disorders

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    Research Output

    Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities

    Andrews, J. A., Berry, J. D., Baloh, R. H., Carberry, N., Cudkowicz, M. E., Dedi, B., Glass, J., Maragakis, N. J., Miller, T. M., Paganoni, S., Rothstein, J. D., Shefner, J. M., Simmons, Z., Weiss, M. D. & Bedlack, R. S., Jan 1 2020, (Accepted/In press) In : Muscle and Nerve.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    A viral toolkit for recording transcription factor-DNA interactions in live mouse tissues

    Cammack, A. J., Moudgil, A., Chen, J., Vasek, M. J., Shabsovich, M., McCullough, K., Yen, A., Lagunas, T., Maloney, S. E., He, J., Chen, X., Hooda, M., Wilkinson, M. N., Miller, T. M., Mitra, R. D. & Dougherty, J. D., May 5 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 18, p. 10003-10014 12 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system

    Pomper, N., Liu, Y., Hoye, M. L., Dougherty, J. D. & Miller, T. M., Dec 1 2020, In : Scientific reports. 10, 1, 4921.

    Research output: Contribution to journal › Article

    Open Access

    • Phase 1-2 Trial of antisense oligonucleotide tofersen for SOD1 ALS

    Miller, T., Cudkowicz, M., Shaw, P. J., Andersen, P. M., Atassi, N., Bucelli, R. C., Genge, A., Glass, J., Ladha, S., Ludolph, A. L., Maragakis, N. J., McDermott, C. J., Pestronk, A., Ravits, J., Salachas, F., Trudell, R., Van Damme, P., Zinman, L., Bennett, C. F., Lane, R. & 11 others, Sandrock, A., Runz, H., Graham, D., Houshyar, H., McCampbell, A., Nestorov, I., Chang, I., McNeill, M., Fanning, L., Fradette, S. & Ferguson, T. A., Jul 9 2020, In : New England Journal of Medicine. 383, 2, p. 109-119 11 p.

    Research output: Contribution to journal › Article

    • 7 Scopus citations

    Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis

    Paganoni, S., Macklin, E. A., Hendrix, S., Berry, J. D., Elliott, M. A., Maiser, S., Karam, C., Caress, J. B., Owegi, M. A., Quick, A., Wymer, J., Goutman, S. A., Heitzman, D., Heiman-Patterson, T., Jackson, C. E., Quinn, C., Rothstein, J. D., Kasarskis, E. J., Katz, J., Jenkins, L. & 39 others, Ladha, S., Miller, T. M., Scelsa, S. N., Vu, T. H., Fournier, C. N., Glass, J. D., Johnson, K. M., Swenson, A., Goyal, N. A., Pattee, G. L., Andres, P. L., Babu, S., Chase, M., Dagostino, D., Dickson, S. P., Ellison, N., Hall, M., Hendrix, K., Kittle, G., McGovern, M., Ostrow, J., Pothier, L., Randall, R., Shefner, J. M., Sherman, A. V., Tustison, E., Vigneswaran, P., Walker, J., Yu, H., Chan, J., Wittes, J., Cohen, J., Klee, J., Leslie, K., Tanzi, R. E., Gilbert, W., Yeramian, P. D., Schoenfeld, D. & Cudkowicz, M. E., Sep 3 2020, In : The New England journal of medicine. 383, 10, p. 919-930 12 p.

    Research output: Contribution to journal › Article