Research output per year
Research output per year
Personal profile
Research interests
My research program focuses on:
1. Gene down regulation strategies (RNAi and antisense oligonucleotides) to understand disease pathogenesis and provide novel therapies for neurodegenerative diseases, in particular amyotrophic lateral sclerosis (ALS)
2. How dysfunction of mitochondria causes loss of motor neurons.
Areas of Clinical Interest
ALS and neurological disorders
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Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice
Schoch, K., Ezerskiy, L. A., Morhaus, M. M., Bannon, R. N., Sauerbeck, A., Shabsovich, M., Jafar-Nejad, P., Rigo, F. & Miller, T. M., Jul 6 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 27, e2100356118.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS
Shefner, J. M., Andrews, J. A., Genge, A., Jackson, C., Lechtzin, N., Miller, T. M., Cockroft, B. M., Meng, L., Wei, J., Wolff, A. A., Malik, F. I., Bodkin, C., Brooks, B. R., Caress, J., Dionne, A., Fee, D., Goutman, S. A., Goyal, N. A., Hardiman, O., Hayat, G. & 33 others, , 2021, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 22, 3-4, p. 287-299 13 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Is presymptomatic ALS perivascular?
Kreple, C., Schoch, K. & Miller, T. M., Apr 2021, In: Nature medicine. 27, 4, p. 585-586 2 p.Research output: Contribution to journal › Comment/debate
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Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis
Paganoni, S., Hendrix, S., Dickson, S. P., Knowlton, N., Macklin, E. A., Berry, J. D., Elliott, M. A., Maiser, S., Karam, C., Caress, J. B., Owegi, M. A., Quick, A., Wymer, J., Goutman, S. A., Heitzman, D., Heiman-Patterson, T. D., Jackson, C. E., Quinn, C., Rothstein, J. D., Kasarskis, E. J. & 41 others, , Jan 2021, In: Muscle and Nerve. 63, 1, p. 31-39 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
The American Genome Center (TAGC), The FALS Sequencing Consortium, The Genomics England Research Consortium, The International ALS/FTD Genomics Consortium (iAFGC), The International FTD Genetics Consortium (IFGC), The International LBD Genomics Consortium (iLBDGC), The NYGC ALS Consortium, the University of Maryland Brain and Tissue Bank and NIH NeuroBioBank & The PROSPECT Consortium, Feb 3 2021, In: Neuron. 109, 3, p. 448-460.e4Research output: Contribution to journal › Article › peer-review
10 Scopus citations