Timothy Ley

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Timothy Ley

Lewis T and Rosalind B Apple Professor of Medicine, Professor of Medicine, Professor of Genetics

 https://orcid.org/0000-0002-9913-0520

    Willing to Mentor

    Available to Mentor:

    Undergraduate Students, Post-Baccalaureate Students, PhD/MSTP Students, Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students, Postdocs, Residents and Fellows

    • 82367
      Citations
    1982 …2024

    Research activity per year

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    • 2018

      Sequencing of tumor DNA to guide cancer risk assessment and therapy

      Spencer, D. H. & Ley, T. J., Apr 10 2018, In: JAMA - Journal of the American Medical Association. 319, 14, p. 1497-1498 2 p.

      Research output: Contribution to journal › Review article › peer-review

      9 Scopus citations
    • 2012

      The pediatric cancer genome project

      Downing, J. R., Wilson, R. K., Zhang, J., Mardis, E. R., Pui, C. H., Ding, L., Ley, T. J. & Evans, W. E., Jun 2012, In: Nature Genetics. 44, 6, p. 619-622 4 p.

      Research output: Contribution to journal › Review article › peer-review

      286 Scopus citations
    • 2010

      International network of cancer genome projects

      Hudson, T. J., Anderson, W., Aretz, A., Barker, A. D., Bell, C., Bernabé, R. R., Bhan, M. K., Calvo, F., Eerola, I., Gerhard, D. S., Guttmacher, A., Guyer, M., Hemsley, F. M., Jennings, J. L., Kerr, D., Klatt, P., Kolar, P., Kusuda, J., Lane, D. P. & Laplace, F. & 241 others, Lu, Y., Nettekoven, G., Ozenberger, B., Peterson, J., Rao, T. S., Remacle, J., Schafer, A. J., Shibata, T., Stratton, M. R., Vockley, J. G., Watanabe, K., Yang, H., Yuen, M. M. F., Knoppers, B. M., Bobrow, M., Cambon-Thomsen, A., Dressler, L. G., Dyke, S. O. M., Joly, Y., Kato, K., Kennedy, K. L., Nicolás, P., Parker, M. J., Rial-Sebbag, E., Romeo-Casabona, C. M., Shaw, K. M., Wallace, S., Wiesner, G. L., Zeps, N., Lichter, P., Biankin, A. V., Chabannon, C., Chin, L., Clément, B., Alava, E. D., Degos, F., Ferguson, M. L., Geary, P., Hayes, D. N., Johns, A. L., Kasprzyk, A., Nakagawa, H., Penny, R., Piris, M. A., Sarin, R., Scarpa, A., De Vijver, M. V., Futreal, P. A., Aburatani, H., Bayés, M., Bowtell, D. D. L., Campbel, P. J., Estivill, X., Grimmond, S. M., Gut, I., Hirst, M., López-Otý́n, C., Majumder, P., Marra, M., McPherson, J. D., Ning, Z., Puente, X. S., Ruan, Y., Stunnenberg, H. G., Swerdlow, H., Velculescu, V. E., Wilson, R. K., Xue, H. H., Yang, L., Spellman, P. T., Bader, G. D., Boutros, P. C., Flicek, P., Getz, G., Guigó, R., Guo, G., Haussler, D., Heath, S., Hubbard, T. J., Jiang, T., Jones, S. M., Li, Q., López-Bigas, N., Luo, R., Muthuswamy, L., Ouellette, B. F. F., Pearson, J. V., Quesada, V., Raphael, B. J., Sander, C., Speed, T. P., Stein, L. D., Stuart, J. M., Teague, J. W., Totoki, Y., Tsunoda, T., Valencia, A., Wheeler, D. A., Wu, H., Zhao, S., Zhou, G., Lathrop, M., Thomas, G., Yoshida, T., Axton, M., Gunter, C., Miller, L. J., Zhang, J., Haider, S. A., Wang, J., Yung, C. K., Cross, A., Liang, Y., Gnaneshan, S., Guberman, J., Hsu, J., Chalmers, D. R. C., Hasel, K. W., Kaan, T. S. H., Lowrance, W. W., Masui, T., Rodriguez, L. L., Vergely, C., Bowtel, D. D. L., Cloonan, N., DeFazio, A., Eshleman, J. R., Etemadmoghadam, D., Gardiner, B. A., Kench, J. G., Sutherland, R. L., Tempero, M. A., Waddell, N. J., Wilson, P. J., Gallinger, S., Tsao, M. S., Shaw, P. A., Petersen, G. M., Mukhopadhyay, D., DePinho, R. A., Thayer, S., Shazand, K., Beck, T., Sam, M., Timms, L., Ballin, V., Ji, J., Zhang, X., Chen, F., Hu, X., Yang, Q., Tian, G., Zhang, L., Xing, X., Li, X., Zhu, Z., Yu, Y., Yu, J., Tost, J., Brennan, P., Holcatova, I., Zaridze, D., Brazma, A., Egevad, L., Prokhortchouk, E., Banks, R. E., Uhlén, M., Viksna, J., Ponten, F., Skryabin, K., Futrea, P. A., Birney, E., Borg, A., Børresen-Dale, A. L., Caldas, C., Foekens, J. A., Martin, S., Reis-Filho, J. S., Richardson, A. L., Sotiriou, C., Veer, L. V. T., Birnbaum, D., Blanche, H., Boucher, P., Boyault, S., Masson-Jacquemier, J. D., Pauporté, I., Pivot, X., Vincent-Salomon, A., Tabone, E., Theillet, C., Treilleux, I., Bioulac-Sage, P., Decaens, T., OiseDegos, F., Franco, D., Gut, M., Samuel, D., Zucman-Rossi, J., Eils, R., Brors, B., Korbe, J. O., Korshunov, A., Landgraf, P., Lehrach, H., Pfister, S., Radlwimmer, B., Reifenberger, G., Taylor, M. D., Kalle, C. V., Majumder, P. P., Rao, T. S., Pederzoli, P., Lawlor, R. T., Delledonne, M., Bardelli, A., Gress, T., Klimstra, D., Zamboni, G., Nakamura, Y., Miyano, S., Fujimoto, A., Campo, E., Sanjosé, S. D., Montserrat, E., González-Dý́az, M., Jares, P., Himmelbaue, H., Bea, S., Aparicio, S., Easton, D. F., Collins, F. S., Compton, C. C., Lander, E. S., Burke, W., Green, A. R., Hamilton, S. R., Kallioniemi, O. P., Ley, T. J., Liu, E. T. & Wainwright, B. J., Apr 15 2010, In: Nature. 464, 7291, p. 993-998 6 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      1888 Scopus citations
    • 2009

      Next-generation sequencing of cancer genomes: Back to the future

      Walter, M. J., Graubert, T. A., DiPersio, J. F., Mardis, E. R., Wilson, R. K. & Ley, T. J., 2009, In: Personalized Medicine. 6, 6, p. 653-662 10 p.

      Research output: Contribution to journal › Review article › peer-review

      21 Scopus citations
    • 2005

      Use of protease proteomics to discover granzyme B substrates

      Bredemeyer, A. J., Townsend, R. R. & Ley, T. J., 2005, In: Immunologic Research. 32, 1-3, p. 143-153 11 p.

      Research output: Contribution to journal › Review article › peer-review

      12 Scopus citations
    • 2003

      The orphan granzymes of humans and mice

      Grossman, W. J., Revell, P. A., Lu, Z. H., Johnson, H., Bredemeyer, A. J. & Ley, T. J., Oct 2003, In: Current Opinion in Immunology. 15, 5, p. 544-552 9 p.

      Research output: Contribution to journal › Review article › peer-review

      140 Scopus citations
    • 2002

      Lymphocyte-mediated cytotoxicity

      Russell, J. H. & Ley, T. J., 2002, In: Annual Review of Immunology. 20, p. 323-370 48 p.

      Research output: Contribution to journal › Review article › peer-review

      887 Scopus citations
    • 2001

      Mouse models of acute promyelocytic leukemia

      Pollock, J. L., Westervelt, P., Walter, M. J., Lane, A. A. & Ley, T. J., 2001, In: Current opinion in hematology. 8, 4, p. 206-211 6 p.

      Research output: Contribution to journal › Review article › peer-review

      23 Scopus citations
    • 2000

      The physician-scientist: Career issues and challenges at the year 2000

      Zemlo, T. R., Garrison, H. H., Partridge, N. C. & Ley, T. J., 2000, In: FASEB Journal. 14, 2, p. 221-230 10 p.

      Research output: Contribution to journal › Review article › peer-review

      195 Scopus citations
    • 1999

      Seed versus soil: The importance of the target cell for transgenic models of human leukemias

      Westervelt, P. & Ley, T. J., Apr 1 1999, In: Blood. 93, 7, p. 2143-2148 6 p.

      Research output: Contribution to journal › Review article › peer-review

      54 Scopus citations
    • 1996

      How do lymphocytes kill tumor cells?

      Graubert, T. A. & Ley, T. J., May 1996, In: Clinical Cancer Research. 2, 5, p. 785-789 5 p.

      Research output: Contribution to journal › Review article › peer-review

      29 Scopus citations

    • Regulation of azurophil granule-associated serine protease genes during myelopoiesis

      Grisolano, J. L. & Ley, T. J., 1996, In: Current opinion in hematology. 3, 1, p. 55-62 8 p.

      Research output: Contribution to journal › Review article › peer-review

      2 Scopus citations
    • 1991

      The pharmacology of hemoglobin switching: Of mice and men

      Ley, T. J., Mar 15 1991, In: Blood. 77, 6, p. 1146-1152 7 p.

      Research output: Contribution to journal › Review article › peer-review

      33 Scopus citations
    • 1985

      Augmentation of hemoglobin synthesis by S-phase specific drugs in the K562 cell line.

      Dean, A., Wu, Y. J., Ley, T., Fordis, C. M. & Schechter, A. N., 1985, In: Progress in Clinical and Biological Research. 191, p. 205-216 12 p.

      Research output: Contribution to journal › Review article › peer-review

      6 Scopus citations

    • Induction of hemoglobin F synthesis in patients with beta thalassemia.

      Ley, T. J. & Nienhuis, A. W., 1985, In: Annual review of medicine. 36, p. 485-498 14 p.

      Research output: Contribution to journal › Review article › peer-review

      14 Scopus citations
    • 1984

      Advances in thalassemia research

      Nienhuis, A. W., Anagnou, N. P. & Ley, T. J., 1984, In: Blood. 63, 4, p. 738-758 21 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      79 Scopus citations
    • 1982

      Transfusion haemosiderosis and chelation therapy.

      Ley, T. J., Griffith, P. & Nienhuis, A. W., Jun 1982, In: Clinics in Haematology. 11, 2, p. 437-464 28 p.

      Research output: Contribution to journal › Review article › peer-review

      46 Scopus citations