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    • 77894
      Citations
    1982 …2024

    Research activity per year

    Search results

    • 2013

      DGIdb: Mining the druggable genome

      Griffith, M., Griffith, O. L., Coffman, A. C., Weible, J. V., Mcmichael, J. F., Spies, N. C., Koval, J., Das, I., Callaway, M. B., Eldred, J. M., Miller, C. A., Subramanian, J., Govindan, R., Kumar, R. D., Bose, R., Ding, L., Walker, J. R., Larson, D. E., Dooling, D. J., Smith, S. M., & 3 othersLey, T. J., Mardis, E. R. & Wilson, R. K., Dec 2013, In: Nature Methods. 10, 12, p. 1209-1210 2 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      375 Scopus citations
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

      Ley, T. J., Miller, C., Ding, L., Raphael, B. J., Mungall, A. J., Robertson, G., Hoadley, K., Triche, T. J., Laird, P. W., Baty, J. D., Fulton, L. L., Fulton, R., Heath, S. E., Kalicki-Veizer, J., Kandoth, C., Klco, J. M., Koboldt, D. C., Kanchi, K. L., Kulkarni, S., Lamprecht, T. L., & 119 othersLarson, D. E., Lin, G., Lu, C., McLellan, M. D., McMichael, J. F., Payton, J., Schmidt, H., Spencer, D. H., Tomasson, M. H., Wallis, J. W., Wartman, L. D., Watson, M. A., Welch, J., Wendl, M. C., Ally, A., Balasundaram, M., Birol, I., Butterfield, Y., Chiu, R., Chu, A., Chuah, E., Chun, H. J., Corbett, R., Dhalla, N., Guin, R., He, A., Hirst, C., Hirst, M., Holt, R. A., Jones, S., Karsan, A., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, K., Parker, J., Pleasance, E., Plettner, P., Schein, J., Stoll, D., Swanson, L., Tam, A., Thiessen, N., Varhol, R., Wye, N., Zhao, Y., Gabriel, S., Getz, G., Sougnez, C., Zou, L., Leiserson, M. D. M., Vandin, F., Wu, H. T., Applebaum, F., Baylin, S. B., Akbani, R., Broom, B. M., Chen, K., Motter, T. C., Nguyen, K., Weinstein, J. N., Zhang, N., Ferguson, M. L., Adams, C., Black, A., Bowen, J., Gastier-Foster, J., Grossman, T., Lichtenberg, T., Wise, L., Davidsen, T., Demchok, J. A., Mills Shaw, K. R., Sheth, M., Sofia, H. J., Yang, L., Downing, J. R., Eley, G., Alonso, S., Ayala, B., Baboud, J., Backus, M., Barletta, S. P., Berton, D. L., Chu, A. L., Girshik, S., Jensen, M. A., Kahn, A., Kothiyal, P., Nicholls, M. C., Pihl, T. D., Pot, D. A., Raman, R., Sanbhadti, R. N., Snyder, E. E., Srinivasan, D., Walton, J., Wan, Y., Wang, Z., Issa, J. P. J., Beau, M. L., Carroll, M., Kantarjian, H., Kornblau, S., Bootwalla, M. S., Lai, P. H., Shen, H., Van Den Berg, D. J., Weisenberger, D. J., Link, D. C., Walter, M. J., Ozenberger, B. A., Mardis, E. R., Westervelt, P., Graubert, T. A., DiPersio, J. F. & Wilson, R. K., May 30 2013, In: New England Journal of Medicine. 368, 22, p. 2059-2074 16 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      3762 Scopus citations
    • Genomic impact of transient low-dose decitabine treatment on primary AMLcells

      Klco, J. M., Spencer, D. H., Lamprecht, T. L., Sarkaria, S. M., Wylie, T., Magrini, V., Hundal, J., Walker, J., Varghese, N., Erdmann-Gilmore, P., Lichti, C. F., Meyer, M. R., Townsend, R. R., Wilson, R. K., Mardis, E. R. & Ley, T. J., Feb 28 2013, In: Blood. 121, 9, p. 1633-1643 11 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      119 Scopus citations
    • Mutational landscape and significance across 12 major cancer types

      Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., Leiserson, M. D. M., Miller, C. A., Welch, J. S., Walter, M. J., Wendl, M. C., Ley, T. J., Wilson, R. K., Raphael, B. J. & Ding, L., 2013, In: Nature. 502, 7471, p. 333-339 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      3299 Scopus citations
    • Notch signaling in acute promyelocytic leukemia

      Grieselhuber, N. R., Klco, J. M., Verdoni, A. M., Lamprecht, T., Sarkaria, S. M., Wartman, L. D. & Ley, T. J., Jul 2013, In: Leukemia. 27, 7, p. 1548-1557 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      31 Scopus citations
    • The authors reply

      Miller, C. A., Wilson, R. K. & Ley, T. J., 2013, In: New England Journal of Medicine. 369, 15, p. 1473 1 p.

      Research output: Contribution to journalLetterpeer-review

      48 Scopus citations
    • The cancer genome atlas pan-cancer analysis project

      Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Sander, C., Stuart, J. M., Chang, K., Creighton, C. J., Davis, C., Donehower, L., Drummond, J., Wheeler, D., Ally, A., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chu, A., Chuah, E., & 316 othersChun, H. J. E., Dhalla, N., Guin, R., Hirst, M., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Robertson, A. G., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Varhol, R. J., Beroukhim, R., Bhatt, A. S., Brooks, A. N., Cherniack, A. D., Freeman, S. S., Gabriel, S. B., Helman, E., Jung, J., Meyerson, M., Ojesina, A. I., Pedamallu, C. S., Saksena, G., Schumacher, S. E., Tabak, B., Zack, T., Lander, E. S., Bristow, C. A., Hadjipanayis, A., Haseley, P., Kucherlapati, R., Lee, S., Lee, E., Luquette, L. J., Mahadeshwar, H. S., Pantazi, A., Parfenov, M., Park, P. J., Protopopov, A., Ren, X., Santoso, N., Seidman, J., Seth, S., Song, X., Tang, J., Xi, R., Xu, A. W., Yang, L., Zeng, D., Auman, J. T., Balu, S., Buda, E., Fan, C., Hoadley, K. A., Jones, C. D., Meng, S., Mieczkowski, P. A., Parker, J. S., Perou, C. M., Roach, J., Shi, Y., Silva, G. O., Tan, D., Veluvolu, U., Waring, S., Wilkerson, M. D., Wu, J., Zhao, W., Bodenheimer, T., Hayes, D. N., Hoyle, A. P., Jeffreys, S. R., Mose, L. E., Simons, J. V., Soloway, M. G., Baylin, S. B., Berman, B. P., Bootwalla, M. S., Danilova, L., Herman, J. G., Hinoue, T., Laird, P. W., Rhie, S. K., Shen, H., Triche, T., Weisenberger, D. J., Carter, S. L., Cibulskis, K., Chin, L., Zhang, J., Sougnez, C., Wang, M., Getz, G., Dinh, H., Doddapaneni, H. V., Gibbs, R., Gunaratne, P., Han, Y., Kalra, D., Kovar, C., Lewis, L., Morgan, M., Morton, D., Muzny, D., Reid, J., Xi, L., Cho, J., Dicara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Liu, Y., Noble, M. S., Stojanov, P., Voet, D., Zhang, H., Zou, L., Stewart, C., Bernard, B., Bressler, R., Eakin, A., Iype, L., Knijnenburg, T., Kramer, R., Kreisberg, R., Leinonen, K., Lin, J., Liu, Y., Miller, M., Reynolds, S. M., Rovira, H., Shmulevich, I., Thorsson, V., Yang, D., Zhang, W., Amin, S., Wu, C. J., Wu, C. C., Akbani, R., Aldape, K., Baggerly, K. A., Broom, B., Casasent, T. D., Cleland, J., Dodda, D., Edgerton, M., Han, L., Herbrich, S. M., Ju, Z., Kim, H., Lerner, S., Li, J., Liang, H., Liu, W., Lorenzi, P. L., Lu, Y., Melott, J., Nguyen, L., Su, X., Verhaak, R., Wang, W., Wong, A., Yang, Y., Yao, J., Yao, R., Yoshihara, K., Yuan, Y., Yung, A. K., Zhang, N., Zheng, S., Ryan, M., Kane, D. W., Aksoy, B. A., Ciriello, G., Dresdner, G., Gao, J., Gross, B., Jacobsen, A., Kahles, A., Ladanyi, M., Lee, W., Lehmann, K. V., Miller, M. L., Ramirez, R., Rätsch, G., Reva, B., Schultz, N., Senbabaoglu, Y., Shen, R., Sinha, R., Sumer, S. O., Sun, Y., Taylor, B. S., Weinhold, N., Fei, S., Spellman, P., Benz, C., Carlin, D., Cline, M., Craft, B., Goldman, M., Haussler, D., Ma, S., Ng, S., Paull, E., Radenbaugh, A., Salama, S., Sokolov, A., Swatloski, T., Uzunangelov, V., Waltman, P., Yau, C., Zhu, J., Hamilton, S. R., Abbott, S., Abbott, R., Dees, N. D., Delehaunty, K., Ding, L., Dooling, D. J., Eldred, J. M., Fronick, C. C., Fulton, R., Fulton, L. L., Kalicki-Veizer, J., Kanchi, K. L., Kandoth, C., Koboldt, D. C., Larson, D. E., Ley, T. J., Lin, L., Lu, C., Magrini, V. J., Mardis, E. R., McLellan, M. D., McMichael, J. F., Miller, C. A., O'Laughlin, M., Pohl, C., Schmidt, H., Smith, S. M., Walker, J., Wallis, J. W., Wendl, M. C., Wilson, R. K., Wylie, T., Zhang, Q., Burton, R., Jensen, M. A., Kahn, A., Pihl, T., Pot, D., Wan, Y., Levine, D. A., Black, A. D., Bowen, J., Frick, J., Gastier-Foster, J. M., Harper, H. A., Helsel, C., Leraas, K. M., Lichtenberg, T. M., McAllister, C., Ramirez, N. C., Sharpe, S., Wise, L., Zmuda, E., Chanock, S. J., Davidsen, T., Demchok, J. A., Eley, G., Felau, I., Sheth, M., Sofia, H., Staudt, L., Tarnuzzer, R., Wang, Z., Yang, L., Zhang, J., Omberg, L., Margolin, A., Raphael, B. J., Vandin, F., Wu, H. T., Leiserson, M. D. M., Benz, S. C., Vaske, C. J., Noushmehr, H., Wolf, D., Veer, L. V. T., Anastassiou, D., Yang, T. H. O., Lopez-Bigas, N., Gonzalez-Perez, A., Tamborero, D., Xia, Z., Li, W., Cho, D. Y., Przytycka, T., Hamilton, M., McGuire, S., Nelander, S., Johansson, P., Jörnsten, R. & Kling, T., Oct 1 2013, In: Nature Genetics. 45, 10, p. 1113-1120 8 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      5204 Scopus citations
    • 2012

      An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia

      Gruber, T. A., Larson Gedman, A., Zhang, J., Koss, C. S., Marada, S., Ta, H. Q., Chen, S. C., Su, X., Ogden, S. K., Dang, J., Wu, G., Gupta, V., Andersson, A. K., Pounds, S., Shi, L., Easton, J., Barbato, M. I., Mulder, H. L., Manne, J., Wang, J., & 29 othersRusch, M., Ranade, S., Ganti, R., Parker, M., Ma, J., Radtke, I., Ding, L., Cazzaniga, G., Biondi, A., Kornblau, S. M., Ravandi, F., Kantarjian, H., Nimer, S. D., Döhner, K., Döhner, H., Ley, T. J., Ballerini, P., Shurtleff, S., Tomizawa, D., Adachi, S., Hayashi, Y., Tawa, A., Shih, L. Y., Liang, D. C., Rubnitz, J. E., Pui, C. H., Mardis, E. R., Wilson, R. K. & Downing, J. R., Nov 13 2012, In: Cancer Cell. 22, 5, p. 683-697 15 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      200 Scopus citations
    • Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells

      Young, M. A., Larson, D. E., Sun, C. W., George, D. R., Ding, L., Miller, C. A., Lin, L., Pawlik, K. M., Chen, K., Fan, X., Schmidt, H., Kalicki-Veizer, J., Cook, L. L., Swift, G. W., Demeter, R. T., Wendl, M. C., Sands, M. S., Mardis, E. R., Wilson, R. K., Townes, T. M., & 1 othersLey, T. J., May 4 2012, In: Cell Stem Cell. 10, 5, p. 570-582 13 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      168 Scopus citations
    • Breakfusion: Targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data

      Chen, K., Wallis, J. W., Kandoth, C., Kalicki-veizer, J. M., Mungall, K. L., Mungall, A. J., Jones, S. J., Marra, M. A., Ley, T. J., Mardis, E. R., Wilson, R. K., Weinstein, J. N. & Ding, L., Jul 2012, In: Bioinformatics. 28, 14, p. 1923-1924 2 p., bts272.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      46 Scopus citations
    • Clonal Architecture of Secondary Acute Myeloid Leukemia

      Walter, M. J., Shen, D., Ding, L., Shao, J., Koboldt, D. C., Chen, K., Larson, D. E., McLellan, M. D., Dooling, D., Abbott, R., Fulton, R., Magrini, V., Schmidt, H., Kalicki-Veizer, J., O'Laughlin, M., Fan, X., Grillot, M., Witowski, S., Heath, S., Frater, J. L., & 9 othersEades, W., Tomasson, M., Westervelt, P., Dipersio, J. F., Link, D. C., Mardis, E. R., Ley, T. J., Wilson, R. K. & Graubert, T. A., Mar 22 2012, In: New England Journal of Medicine. 366, 12, p. 1090-1098 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      645 Scopus citations
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

      Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., McMichael, J. F., Wallis, J. W., Lu, C., Shen, D., Harris, C. C., Dooling, D. J., Fulton, R. S., Fulton, L. L., Chen, K., Schmidt, H., & 19 othersKalicki-Veizer, J., Magrini, V. J., Cook, L., McGrath, S. D., Vickery, T. L., Wendl, M. C., Heath, S., Watson, M. A., Link, D. C., Tomasson, M. H., Shannon, W. D., Payton, J. E., Kulkarni, S., Westervelt, P., Walter, M. J., Graubert, T. A., Mardis, E. R., Wilson, R. K. & Dipersio, J. F., Jan 26 2012, In: Nature. 481, 7382, p. 506-510 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1637 Scopus citations
    • Erratum: The Pediatric Cancer Genome Project (Nature Genetics (2012) 44 (619-622))

      Downing, J. R., Wilson, R. K., Zhang, J., Mardis, E. R., Pui, C. H., Ding, L., Ley, T. J. & Evans, W. E., Sep 2012, In: Nature Genetics. 44, 9, p. 1072 1 p.

      Research output: Contribution to journalComment/debate

      Open Access
    • Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice

      Wartman, L. D., Welch, J. S., Uy, G. L., Klco, J. M., Lamprecht, T., Varghese, N., Nagarajan, R. & Ley, T. J., Oct 8 2012, In: PloS one. 7, 10, e46529.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      16 Scopus citations
    • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

      Graubert, T. A., Shen, D., Ding, L., Okeyo-Owuor, T., Lunn, C. L., Shao, J., Krysiak, K., Harris, C. C., Koboldt, D. C., Larson, D. E., McLellan, M. D., Dooling, D. J., Abbott, R. M., Fulton, R. S., Schmidt, H., Kalicki-Veizer, J., O'Laughlin, M., Grillot, M., Baty, J., Heath, S., & 10 othersFrater, J. L., Nasim, T., Link, D. C., Tomasson, M. H., Westervelt, P., Dipersio, J. F., Mardis, E. R., Ley, T. J., Wilson, R. K. & Walter, M. J., Jan 2012, In: Nature Genetics. 44, 1, p. 53-57 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      478 Scopus citations
    • Somaticsniper: Identification of somatic point mutations in whole genome sequencing data

      Larson, D. E., Harris, C. C., Chen, K., Koboldt, D. C., Abbott, T. E., Dooling, D. J., Ley, T. J., Mardis, E. R., Wilson, R. K. & Ding, L., Feb 2012, In: Bioinformatics. 28, 3, p. 311-317 7 p., btr665.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      453 Scopus citations
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

      Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., Lu, C., Chen, S. C., Wei, L., Collins-Underwood, J. R., Ma, J., Roberts, K. G., Pounds, S. B., Ulyanov, A., Becksfort, J., Gupta, P., & 49 othersHuether, R., Kriwacki, R. W., Parker, M., McGoldrick, D. J., Zhao, D., Alford, D., Espy, S., Bobba, K. C., Song, G., Pei, D., Cheng, C., Roberts, S., Barbato, M. I., Campana, D., Coustan-Smith, E., Shurtleff, S. A., Raimondi, S. C., Kleppe, M., Cools, J., Shimano, K. A., Hermiston, M. L., Doulatov, S., Eppert, K., Laurenti, E., Notta, F., Dick, J. E., Basso, G., Hunger, S. P., Loh, M. L., Devidas, M., Wood, B., Winter, S., Dunsmore, K. P., Fulton, R. S., Fulton, L. L., Hong, X., Harris, C. C., Dooling, D. J., Ochoa, K., Johnson, K. J., Obenauer, J. C., Evans, W. E., Pui, C. H., Naeve, C. W., Ley, T. J., Mardis, E. R., Wilson, R. K., Downing, J. R. & Mullighan, C. G., Jan 12 2012, In: Nature. 481, 7380, p. 157-163 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1296 Scopus citations
    • The origin and evolution of mutations in acute myeloid leukemia

      Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., Kandoth, C., Fulton, R. S., McLellan, M. D., Dooling, D. J., Wallis, J. W., Chen, K., Harris, C. C., Schmidt, H. K., Kalicki-Veizer, J. M., Lu, C., & 34 othersZhang, Q., Lin, L., O'Laughlin, M. D., McMichael, J. F., Delehaunty, K. D., Fulton, L. A., Magrini, V. J., McGrath, S. D., Demeter, R. T., Vickery, T. L., Hundal, J., Cook, L. L., Swift, G. W., Reed, J. P., Alldredge, P. A., Wylie, T. N., Walker, J. R., Watson, M. A., Heath, S. E., Shannon, W. D., Varghese, N., Nagarajan, R., Payton, J. E., Baty, J. D., Kulkarni, S., Klco, J. M., Tomasson, M. H., Westervelt, P., Walter, M. J., Graubert, T. A., Dipersio, J. F., Ding, L., Mardis, E. R. & Wilson, R. K., Jul 20 2012, In: Cell. 150, 2, p. 264-278 15 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1267 Scopus citations
    • The pediatric cancer genome project

      Downing, J. R., Wilson, R. K., Zhang, J., Mardis, E. R., Pui, C. H., Ding, L., Ley, T. J. & Evans, W. E., Jun 2012, In: Nature Genetics. 44, 6, p. 619-622 4 p.

      Research output: Contribution to journalReview articlepeer-review

      277 Scopus citations
    • Whole-genome analysis informs breast cancer response to aromatase inhibition

      Ellis, M. J., Ding, L., Shen, D., Luo, J., Suman, V. J., Wallis, J. W., Van Tine, B. A., Hoog, J., Goiffon, R. J., Goldstein, T. C., Ng, S., Lin, L., Crowder, R., Snider, J., Ballman, K., Weber, J., Chen, K., Koboldt, D. C., Kandoth, C., Schierding, W. S., & 39 othersMcMichael, J. F., Miller, C. A., Lu, C., Harris, C. C., McLellan, M. D., Wendl, M. C., Deschryver, K., Allred, D. C., Esserman, L., Unzeitig, G., Margenthaler, J., Babiera, G. V., Marcom, P. K., Guenther, J. M., Leitch, M., Hunt, K., Olson, J., Tao, Y., Maher, C. A., Fulton, L. L., Fulton, R. S., Harrison, M., Oberkfell, B., Du, F., Demeter, R., Vickery, T. L., Elhammali, A., Piwnica-Worms, H., McDonald, S., Watson, M., Dooling, D. J., Ota, D., Chang, L. W., Bose, R., Ley, T. J., Piwnica-Worms, D., Stuart, J. M., Wilson, R. K. & Mardis, E. R., Jun 21 2012, In: Nature. 486, 7403, p. 353-360 8 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      861 Scopus citations
    • 2011

      Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML

      Link, D. C., Schuettpelz, L. G., Shen, D., Wang, J., Walter, M. J., Kulkarni, S., Payton, J. E., Ivanovich, J., Goodfellow, P. J., Le Beau, M., Koboldt, D. C., Dooling, D. J., Fulton, R. S., Bender, R. H. F., Fulton, L. L., Delehaunty, K. D., Fronick, C. C., Appelbaum, E. L., Schmidt, H., Abbott, R., & 12 othersO'Laughlin, M., Chen, K., McLellan, M. D., Varghese, N., Nagarajan, R., Heath, S., Graubert, T. A., Ding, L., Ley, T. J., Zambetti, G. P., Wilson, R. K. & Mardis, E. R., Apr 20 2011, In: JAMA. 305, 15, p. 1568-1576 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      140 Scopus citations
    • PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice

      Welch, J. S., Yuan, W. & Ley, T. J., Apr 1 2011, In: Journal of Clinical Investigation. 121, 4, p. 1636-1645 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      33 Scopus citations
    • Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice

      Welch, J. S., Klco, J. M., Varghese, N., Nagarajan, R. & Ley, T. J., Feb 24 2011, In: Blood. 117, 8, p. 2460-2468 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      15 Scopus citations
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

      Walter, M. J., Ding, L., Shen, D., Shao, J., Grillot, M., McLellan, M., Fulton, R., Schmidt, H., Kalicki-Veizer, J., O'Laughlin, M., Kandoth, C., Baty, J., Westervelt, P., Dipersio, J. F., Mardis, E. R., Wilson, R. K., Ley, T. J. & Graubert, T. A., Jul 2011, In: Leukemia. 25, 7, p. 1153-1158 6 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      465 Scopus citations
    • Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

      Wartman, L. D., Larson, D. E., Xiang, Z., Ding, L., Chen, K., Lin, L., Cahan, P., Klco, J. M., Welch, J. S., Li, C., Payton, J. E., Uy, G. L., Varghese, N., Ries, R. E., Hoock, M., Koboldt, D. C., McLellan, M. D., Schmidt, H., Fulton, R. S., Abbott, R. M., & 12 othersCook, L., McGrath, S. D., Fan, X., Dukes, A. F., Vickery, T., Kalicki, J., Lamprecht, T. L., Graubert, T. A., Tomasson, M. H., Mardis, E. R., Wilson, R. K. & Ley, T. J., Apr 1 2011, In: Journal of Clinical Investigation. 121, 4, p. 1445-1455 11 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      86 Scopus citations
    • Use of whole-genome sequencing to diagnose a cryptic fusion oncogene

      Welch, J. S., Westervelt, P., Ding, L., Larson, D. E., Klco, J. M., Kulkarni, S., Wallis, J., Chen, K., Payton, J. E., Fulton, R. S., Veizer, J., Schmidt, H., Vickery, T. L., Heath, S., Watson, M. A., Tomasson, M. H., Link, D. C., Graubert, T. A., DiPersio, J. F., Mardis, E. R., & 2 othersLey, T. J. & Wilson, R. K., Apr 20 2011, In: JAMA. 305, 15, p. 1577-1584 8 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      220 Scopus citations
    • Whole-genome sequencing and acute promyelocytic leukemia - Reply

      Westervelt, P., Welch, J. S. & Ley, T. J., Aug 10 2011, In: JAMA. 306, 6, p. 610-611 2 p.

      Research output: Contribution to journalLetterpeer-review

    • 2010

      A protease-resistant PML-RARα has increased leukemogenic potential in a murine model of acute promyelocytic leukemia

      Uy, G. L., Lane, A. A., Welch, J. S., Grieselhuber, N. R., Payton, J. E. & Ley, T. J., Nov 4 2010, In: Blood. 116, 18, p. 3604-3610 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      13 Scopus citations
    • Complete characterization of the microRNAome in a patient with acute myeloid leukemia

      Ramsingh, G., Koboldt, D. C., Trissal, M., Chiappinelli, K. B., Wylie, T., Koul, S., Chang, L. W., Nagarajan, R., Fehniger, T. A., Goodfellow, P., Magrini, V., Wilson, R. K., Ding, L., Ley, T. J., Mardis, E. R. & Link, D. C., Dec 9 2010, In: Blood. 116, 24, p. 5316-5326 11 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      58 Scopus citations
    • DNMT3A mutations in acute myeloid leukemia

      Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., Harris, C. C., Lichti, C. F., Townsend, R. R., Fulton, R. S., Dooling, D. J., Koboldt, D. C., Schmidt, H., Zhang, Q., Osborne, J. R., Lin, L., & 28 othersO'Laughlin, M., McMichael, J. F., Delehaunty, K. D., McGrath, S. D., Fulton, L. A., Magrini, V. J., Vickery, T. L., Hundal, J., Cook, L. L., Conyers, J. J., Swift, G. W., Reed, J. P., Alldredge, P. A., Wylie, T., Walker, J., Kalicki, J., Watson, M. A., Heath, S., Shannon, W. D., Varghese, N., Nagarajan, R., Westervelt, P., Tomasson, M. H., Link, D. C., Graubert, T. A., DiPersio, J. F., Mardis, E. R. & Wilson, R. K., Dec 16 2010, In: New England Journal of Medicine. 363, 25, p. 2424-2433 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1632 Scopus citations
    • Genome remodelling in a basal-like breast cancer metastasis and xenograft

      Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L. L., Abbott, R. M., Hoog, J., Dooling, D. J., Koboldt, D. C., Schmidt, H., Kalicki, J., Zhang, Q., Chen, L., Lin, L., Wendl, M. C., & 49 othersMcMichael, J. F., Magrini, V. J., Cook, L., McGrath, S. D., Vickery, T. L., Appelbaum, E., Deschryver, K., Davies, S., Guintoli, T., Lim, L., Crowder, R., Tao, Y., Snider, J. E., Smith, S. M., Dukes, A. F., Sanderson, G. E., Pohl, C. S., Delehaunty, K. D., Fronick, C. C., Pape, K. A., Reed, J. S., Robinson, J. S., Hodges, J. S., Schierding, W., Dees, N. D., Shen, D., Locke, D. P., Wiechert, M. E., Eldred, J. M., Peck, J. B., Oberkfell, B. J., Lolofie, J. T., Du, F., Hawkins, A. E., Oĝlaughlin, M. D., Bernard, K. E., Cunningham, M., Elliott, G., Mason, M. D., Thompson, D. M., Ivanovich, J. L., Goodfellow, P. J., Perou, C. M., Weinstock, G. M., Aft, R., Watson, M., Ley, T. J., Wilson, R. K. & Mardis, E. R., Apr 15 2010, In: Nature. 464, 7291, p. 999-1005 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1015 Scopus citations
    • Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease

      Cai, S. F., Cao, X., Hassan, A., Fehniger, T. A. & Ley, T. J., Mar 4 2010, In: Blood. 115, 9, p. 1669-1677 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      27 Scopus citations
    • International network of cancer genome projects

      Hudson, T. J., Anderson, W., Aretz, A., Barker, A. D., Bell, C., Bernabé, R. R., Bhan, M. K., Calvo, F., Eerola, I., Gerhard, D. S., Guttmacher, A., Guyer, M., Hemsley, F. M., Jennings, J. L., Kerr, D., Klatt, P., Kolar, P., Kusuda, J., Lane, D. P., Laplace, F., & 241 othersLu, Y., Nettekoven, G., Ozenberger, B., Peterson, J., Rao, T. S., Remacle, J., Schafer, A. J., Shibata, T., Stratton, M. R., Vockley, J. G., Watanabe, K., Yang, H., Yuen, M. M. F., Knoppers, B. M., Bobrow, M., Cambon-Thomsen, A., Dressler, L. G., Dyke, S. O. M., Joly, Y., Kato, K., Kennedy, K. L., Nicolás, P., Parker, M. J., Rial-Sebbag, E., Romeo-Casabona, C. M., Shaw, K. M., Wallace, S., Wiesner, G. L., Zeps, N., Lichter, P., Biankin, A. V., Chabannon, C., Chin, L., Clément, B., Alava, E. D., Degos, F., Ferguson, M. L., Geary, P., Hayes, D. N., Johns, A. L., Kasprzyk, A., Nakagawa, H., Penny, R., Piris, M. A., Sarin, R., Scarpa, A., De Vijver, M. V., Futreal, P. A., Aburatani, H., Bayés, M., Bowtell, D. D. L., Campbel, P. J., Estivill, X., Grimmond, S. M., Gut, I., Hirst, M., López-Otý́n, C., Majumder, P., Marra, M., McPherson, J. D., Ning, Z., Puente, X. S., Ruan, Y., Stunnenberg, H. G., Swerdlow, H., Velculescu, V. E., Wilson, R. K., Xue, H. H., Yang, L., Spellman, P. T., Bader, G. D., Boutros, P. C., Flicek, P., Getz, G., Guigó, R., Guo, G., Haussler, D., Heath, S., Hubbard, T. J., Jiang, T., Jones, S. M., Li, Q., López-Bigas, N., Luo, R., Muthuswamy, L., Ouellette, B. F. F., Pearson, J. V., Quesada, V., Raphael, B. J., Sander, C., Speed, T. P., Stein, L. D., Stuart, J. M., Teague, J. W., Totoki, Y., Tsunoda, T., Valencia, A., Wheeler, D. A., Wu, H., Zhao, S., Zhou, G., Lathrop, M., Thomas, G., Yoshida, T., Axton, M., Gunter, C., Miller, L. J., Zhang, J., Haider, S. A., Wang, J., Yung, C. K., Cross, A., Liang, Y., Gnaneshan, S., Guberman, J., Hsu, J., Chalmers, D. R. C., Hasel, K. W., Kaan, T. S. H., Lowrance, W. W., Masui, T., Rodriguez, L. L., Vergely, C., Bowtel, D. D. L., Cloonan, N., DeFazio, A., Eshleman, J. R., Etemadmoghadam, D., Gardiner, B. A., Kench, J. G., Sutherland, R. L., Tempero, M. A., Waddell, N. J., Wilson, P. J., Gallinger, S., Tsao, M. S., Shaw, P. A., Petersen, G. M., Mukhopadhyay, D., DePinho, R. A., Thayer, S., Shazand, K., Beck, T., Sam, M., Timms, L., Ballin, V., Ji, J., Zhang, X., Chen, F., Hu, X., Yang, Q., Tian, G., Zhang, L., Xing, X., Li, X., Zhu, Z., Yu, Y., Yu, J., Tost, J., Brennan, P., Holcatova, I., Zaridze, D., Brazma, A., Egevad, L., Prokhortchouk, E., Banks, R. E., Uhlén, M., Viksna, J., Ponten, F., Skryabin, K., Futrea, P. A., Birney, E., Borg, A., Børresen-Dale, A. L., Caldas, C., Foekens, J. A., Martin, S., Reis-Filho, J. S., Richardson, A. L., Sotiriou, C., Veer, L. V. T., Birnbaum, D., Blanche, H., Boucher, P., Boyault, S., Masson-Jacquemier, J. D., Pauporté, I., Pivot, X., Vincent-Salomon, A., Tabone, E., Theillet, C., Treilleux, I., Bioulac-Sage, P., Decaens, T., OiseDegos, F., Franco, D., Gut, M., Samuel, D., Zucman-Rossi, J., Eils, R., Brors, B., Korbe, J. O., Korshunov, A., Landgraf, P., Lehrach, H., Pfister, S., Radlwimmer, B., Reifenberger, G., Taylor, M. D., Kalle, C. V., Majumder, P. P., Rao, T. S., Pederzoli, P., Lawlor, R. T., Delledonne, M., Bardelli, A., Gress, T., Klimstra, D., Zamboni, G., Nakamura, Y., Miyano, S., Fujimoto, A., Campo, E., Sanjosé, S. D., Montserrat, E., González-Dý́az, M., Jares, P., Himmelbaue, H., Bea, S., Aparicio, S., Easton, D. F., Collins, F. S., Compton, C. C., Lander, E. S., Burke, W., Green, A. R., Hamilton, S. R., Kallioniemi, O. P., Ley, T. J., Liu, E. T. & Wainwright, B. J., Apr 15 2010, In: Nature. 464, 7291, p. 993-998 6 p.

      Research output: Contribution to journalReview articlepeer-review

      Open Access
      1844 Scopus citations
    • Latent herpesvirus infection arms NK cells

      White, D. W., Keppel, C. R., Schneider, S. E., Reese, T. A., Coder, J., Payton, J. E., Ley, T. J., Virgin, H. W. & Fehniger, T. A., Jun 3 2010, In: Blood. 115, 22, p. 4377-4383 7 p.

      Research output: Contribution to journalArticlepeer-review

      58 Scopus citations
    • Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

      Xiang, Z., Luo, H., Payton, J. E., Cain, J., Ley, T. J., Opferman, J. T. & Tomasson, M. H., Jun 1 2010, In: Journal of Clinical Investigation. 120, 6, p. 2109-2118 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      99 Scopus citations
    • Next-generation sequencing identifies the natural killer cell microRNA transcriptome

      Fehniger, T. A., Wylie, T., Germino, E., Leong, J. W., Magrini, V. J., Koul, S., Keppel, C. R., Schneider, S. E., Koboldt, D. C., Sullivan, R. P., Heinz, M. E., Crosby, S. D., Nagarajan, R., Ramsingh, G., Link, D. C., Ley, T. J. & Mardis, E. R., Nov 2010, In: Genome research. 20, 11, p. 1590-1604 15 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      121 Scopus citations
    • POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature

      Fortier, J. M., Payton, J. E., Cahan, P., Ley, T. J., Walter, M. J. & Graubert, T. A., May 2010, In: Leukemia. 24, 5, p. 950-957 8 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      20 Scopus citations
    • 2009

      Acquired copy number alterations in adult acute myeloid leukemia genomes

      Walter, M. J., Payton, J. E., Ries, R. E., Shannon, W. D., Deshmukh, H., Zhao, Y., Baty, J., Heath, S., Westervelt, P., Watson, M. A., Tomasson, M. H., Nagarajan, R., O'Gara, B. P., Bloomfield, C. D., Mrózek, K., Selzer, R. R., Richmond, T. A., Kitzman, J., Geoghegan, J., Eis, P. S., & 9 othersMaupin, R., Fulton, R. S., McLellan, M., Wilson, R. K., Mardis, E. R., Link, D. C., Graubert, T. A., DiPersio, J. F. & Ley, T. J., Aug 4 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 31, p. 12950-12955 6 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      213 Scopus citations
    • BreakDancer: An algorithm for high-resolution mapping of genomic structural variation

      Chen, K., Wallis, J. W., McLellan, M. D., Larson, D. E., Kalicki, J. M., Pohl, C. S., McGrath, S. D., Wendl, M. C., Zhang, Q., Locke, D. P., Shi, X., Fulton, R. S., Ley, T. J., Wilson, R. K., Ding, L. & Mardis, E. R., 2009, In: Nature Methods. 6, 9, p. 677-681 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1116 Scopus citations
    • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

      Nervi, B., Ramirez, P., Rettig, M. P., Uy, G. L., Holt, M. S., Ritchey, J. K., Prior, J. L., Piwnica-Worms, D., Bridger, G., Ley, T. J. & DiPersio, J. F., 2009, In: Blood. 113, 24, p. 6206-6214 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      420 Scopus citations
    • Differential expression of granzyme B and C in murine cytotoxic lymphocytes

      Cai, S. F., Fehniger, T. A., Cao, X., Mayer, J. C., Brune, J. D., French, A. R. & Ley, T. J., May 15 2009, In: Journal of Immunology. 182, 10, p. 6287-6297 11 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      28 Scopus citations
    • High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

      Payton, J. E., Grieselhuber, N. R., Chang, L. W., Murakami, M., Geiss, G. K., Link, D. C., Nagarajan, R., Watson, M. A. & Ley, T. J., Jun 1 2009, In: Journal of Clinical Investigation. 119, 6, p. 1714-1726 13 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      123 Scopus citations
    • Interleukin 12 stimulates IFN-γ-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance

      Cao, X., Leonard, K., Collins, L. I., Cai, S. F., Mayer, J. C., Payton, J. E., Walter, M. J., Piwnica-Worms, D., Schreiber, R. D. & Ley, T. J., Nov 15 2009, In: Cancer research. 69, 22, p. 8700-8709 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      64 Scopus citations
    • Next-generation sequencing of cancer genomes: Back to the future

      Walter, M. J., Graubert, T. A., DiPersio, J. F., Mardis, E. R., Wilson, R. K. & Ley, T. J., 2009, In: Personalized Medicine. 6, 6, p. 653-662 10 p.

      Research output: Contribution to journalReview articlepeer-review

      21 Scopus citations
    • Recurring mutations found by sequencing an acute myeloid leukemia genome

      Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., Fulton, L. A., Locke, D. P., Magrini, V. J., Abbott, R. M., Vickery, T. L., Reed, J. S., Robinson, J. S., Wylie, T., Smith, S. M., Carmichael, L., & 38 othersEldred, J. M., Harris, C. C., Walker, J., Peck, J. B., Du, F., Dukes, A. F., Sanderson, G. E., Brummett, A. M., Clark, E., McMichael, J. F., Meyer, R. J., Schindler, J. K., Pohl, C. S., Wallis, J. W., Shi, X., Lin, L., Schmidt, H., Tang, Y., Haipek, C., Wiechert, M. E., Ivy, J. V., Kalicki, J., Elliott, G., Ries, R. E., Payton, J. E., Westervelt, P., Tomasson, M. H., Watson, M. A., Baty, J., Heath, S., Shannon, W. D., Nagarajan, R., Link, D. C., Walter, M. J., Graubert, T. A., DiPersio, J. F., Wilson, R. K. & Ley, T. J., Sep 10 2009, In: New England Journal of Medicine. 361, 11, p. 1058-1066 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1896 Scopus citations
    • 2008

      Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

      Wei, L. W., Payton, J. E., Yuan, W., Ley, T. J., Nagarajan, R. & Stormo, G. D., Feb 21 2008, In: Genome biology. 9, 2, R38.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      21 Scopus citations
    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

      Ley, T. J., Mardis, E. R., Ding, L., Fulton, B., McLellan, M. D., Chen, K., Dooling, D., Dunford-Shore, B. H., McGrath, S., Hickenbotham, M., Cook, L., Abbott, R., Larson, D. E., Koboldt, D. C., Pohl, C., Smith, S., Hawkins, A., Abbott, S., Locke, D., Hillier, L. W., & 28 othersMiner, T., Fulton, L., Magrini, V., Wylie, T., Glasscock, J., Conyers, J., Sander, N., Shi, X., Osborne, J. R., Minx, P., Gordon, D., Chinwalla, A., Zhao, Y., Ries, R. E., Payton, J. E., Westervelt, P., Tomasson, M. H., Watson, M., Baty, J., Ivanovich, J., Heath, S., Shannon, W. D., Nagarajan, R., Walter, M. J., Link, D. C., Graubert, T. A., DiPersio, J. F. & Wilson, R. K., Nov 6 2008, In: Nature. 456, 7218, p. 66-72 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1051 Scopus citations
    • Identification of Somatic JAK1 mutations in patients with acute myeloid leukemia

      Xiang, Z., Zhao, Y., Mitaksov, V., Fremont, D. H., Kasai, Y., Molitoris, A., Ries, R. E., Miner, T. L., McLellan, M. D., DiPersio, J. F., Link, D. C., Payton, J. E., Graubert, T. A., Watson, M., Shannon, W., Heath, S. E., Nagarajan, R., Mardis, E. R., Wilson, R. K., Ley, T. J., & 1 othersTomasson, M. H., May 1 2008, In: Blood. 111, 9, p. 4809-4812 4 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      82 Scopus citations
    • Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice

      Funk, R. K., Maxwell, T. J., Izumi, M., Edwin, D., Kreisel, F., Ley, T. J., Cheverud, J. M. & Graubert, T. A., Aug 15 2008, In: Blood. 112, 4, p. 1434-1442 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      13 Scopus citations
    • Sociology: The gender gap in NIH grant applications

      Ley, T. J. & Hamilton, B. H., Dec 5 2008, In: Science. 322, 5907, p. 1472-1474 3 p.

      Research output: Contribution to journalShort surveypeer-review

      177 Scopus citations