Timothy Ley

Research output

Research output per year 1982 2018 2022 2023

• 262 Article
• 18 Comment/debate
• 17 Letter
• 17 Review article
• 2 More
  • 2 Short survey

Research output per year

Research output per year

Search results

• 2018

  Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

  Wong, T. N., Miller, C. A., Jotte, M. R. M., Bagegni, N., Baty, J. D., Schmidt, A. P., Cashen, A. F., Duncavage, E. J., Helton, N. M., Fiala, M., Fulton, R. S., Heath, S. E., Janke, M., Luber, K., Westervelt, P., Vij, R., Dipersio, J. F., Welch, J. S., Graubert, T. A., Walter, M. J., & 2 othersLey, T. J. & Link, D. C., Dec 1 2018, In: Nature communications. 9, 1, 455.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mutations 100%
  • Mutation 72%
  • Clone Cells 68%
  • expansion 53%
  • transplantation 53%
  116 Scopus citations

• Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

  The Cancer Genome Atlas Research Network, Apr 9 2018, In: Cancer Cell. 33, 4, p. 721-735.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenocarcinoma 100%
  • Genome 49%
  • Chromosomal Instability 45%
  • Neoplasms 41%
  • Rectum 36%
  309 Scopus citations

• Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

  The Cancer Genome Atlas Research Network, Aug 13 2018, In: Cancer Cell. 34, 2, p. 211-224.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alternative Splicing 100%
  • Neoplasms 29%
  • Exons 12%
  • Peptides 9%
  • Whole Exome Sequencing 9%
  450 Scopus citations

• Comprehensive Characterization of Cancer Driver Genes and Mutations

  The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In: Cell. 173, 2, p. 371-385.e18

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Genes 100%
  • Mutation 77%
  • Neoplasms 29%
  • Oncogenic 25%
  • Catalogs 11%
  1074 Scopus citations

• Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

  The Cancer Genome Atlas Research Network, Oct 30 2018, In: Cell Reports. 25, 5, p. 1304-1317.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNA 100%
  • Heterogeneity 75%
  • Mutation 68%
  • Neoplasms 26%
  • Squamous Cell Neoplasms 20%
  222 Scopus citations

• DNMT3A ^R882 -associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A ^R882C OCI-AML3 leukemia cell line

  Chen, D., Christopher, M., Helton, N. M., Ferguson, I., Ley, T. J. & Spencer, D. H., Apr 1 2018, In: Blood cancer journal. 8, 4, 38.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  7 Scopus citations

• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

  The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 227-238.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human Development 100%
  • Mutation 78%
  • Peptide 53%
  • Drug 48%
  • Gene Fusion 45%
  318 Scopus citations

• Erratum: The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))

  The Cancer Genome Atlas Research Network, Jun 19 2018, In: Cell Reports. 23, 12, p. 3698 1 p.

  Research output: Contribution to journal › Comment/debate

  Open Access

  • Atlases 100%
  • Renal Cell Carcinoma 89%
  • Names 88%
  • Emotions 73%
  • Error 69%
  83 Scopus citations

• Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))

  The MC3 Working Group, The Cancer Genome Atlas Research Network, The MC3 Working Group & The Cancer Genome Atlas Research Network lding@wustl.edu, Aug 9 2018, In: Cell. 174, 4, p. 1034-1035 2 p.

  Research output: Contribution to journal › Comment/debate

  Open Access

  • Neoplasm Genes 100%
  • Mutation 77%
  • Adenocarcinoma 72%
  • ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate 48%
  • Error 34%
  230 Scopus citations

• Expression profiling of snoRNAs in normal hematopoiesis and AML

  Warner, W. A., Spencer, D. H., Trissal, M., White, B. S., Helton, N., Ley, T. J. & Link, D. C., Jan 23 2018, In: Blood Advances. 2, 2, p. 151-163 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Nucleolar RNA 100%
  • Hematopoiesis 75%
  • Acute Myeloid Leukemia 65%
  • Spliceosomes 11%
  • RNA Splicing 11%
  32 Scopus citations

• Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 194-212.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • Squamous Cell Carcinoma 98%
  • MicroRNA 96%
  • MicroRNAs 49%
  • Epithelial Cells 42%
  197 Scopus citations

• Genomic and Functional Approaches to Understanding Cancer Aneuploidy

  The Cancer Genome Atlas Research Network, Apr 9 2018, In: Cancer Cell. 33, 4, p. 676-689.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aneuploidy 100%
  • Chromosomes 55%
  • Neoplasms 29%
  • Mutation Rate 24%
  • Genome 23%
  499 Scopus citations

• Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 239-254.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Repair-Deficiency Disorders 100%
  • Atlases 73%
  • DNA Damage 59%
  • Mutation 57%
  • Genome 46%
  577 Scopus citations

• Immune escape of relapsed AML cells after allogeneic transplantation

  Christopher, M. J., Petti, A. A., Rettig, M. P., Miller, C. A., Chendamarai, E., Duncavage, E. J., Klco, J. M., Helton, N. M., O'Laughlin, M., Fronick, C. C., Fulton, R. S., Wilson, R. K., Wartman, L. D., Welch, J. S., Heath, S. E., Baty, J. D., Payton, J. E., Graubert, T. A., Link, D. C., Walter, M. J., & 3 othersWestervelt, P., Ley, T. J. & DiPersio, J. F., Dec 13 2018, In: New England Journal of Medicine. 379, 24, p. 2330-2341 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Homologous Transplantation 100%
  • Myeloid Cells 90%
  • Acute Myeloid Leukemia 84%
  • Recurrence 50%
  • Transplantation 30%
  252 Scopus citations

• Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 213-226.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitin 100%
  • Mutation 42%
  • Protein 41%
  • Molecular Cluster 32%
  • Neoplasms 32%
  66 Scopus citations

• lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

  The Cancer Genome Atlas Research Network, Apr 9 2018, In: Cancer Cell. 33, 4, p. 706-720.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Long Noncoding RNA 100%
  • Epigenomics 80%
  • Cell Cycle 72%
  • Genes 37%
  • Neoplasms 29%
  334 Scopus citations

• Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 172-180.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor 100%
  • Machine Learning 70%
  • Atlases 66%
  • Mutation 52%
  • Genome 42%
  84 Scopus citations

• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

  The Cancer Genome Atlas Research Network, Apr 5 2018, In: Cell. 173, 2, p. 338-354.e15

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenic 100%
  • Machine Learning 80%
  • Drug Target 27%
  • Neoplasms 23%
  • Heterogeneity 21%
  972 Scopus citations

• MIR142 loss-of-function mutations derepress ASH1L to increase HOXA gene expression and promote leukemogenesis

  Trissal, M. C., Wong, T. N., Yao, J. C., Ramaswamy, R., Kuo, I., Baty, J., Sun, Y., Jih, G., Parikh, N., Berrien-Elliott, M. M., Fehniger, T. A., Ley, T. J., Maillard, I., Reddy, P. R. & Link, D. C., Jul 1 2018, In: Cancer research. 78, 13, p. 3510-3521 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Loss of Function Mutation 100%
  • Acute Myeloid Leukemia 84%
  • antineoplaston A10 72%
  • Gene Expression 53%
  • Granulocyte Precursor Cells 38%
  30 Scopus citations

• Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 255-269.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metabolic 100%
  • Neoplasms 39%
  • Carbohydrates 26%
  • Nucleotide-Carbohydrate 25%
  • Pharmacological Metabolism 21%
  144 Scopus citations

• Mutation clearance after transplantation for myelodysplastic syndrome

  Duncavage, E. J., Jacoby, M. A., Chang, G. S., Miller, C. A., Edwin, N., Shao, J., Elliott, K., Robinson, J., Abel, H., Fulton, R. S., Fronick, C. C., O'Laughlin, M., Heath, S. E., Brendel, K., Saba, R., Wartman, L. D., Christopher, M. J., Pusic, I., Welch, J. S., Uy, G. L., & 7 othersLink, D. C., DiPersio, J. F., Westervelt, P., Ley, T. J., Trinkaus, K., Graubert, T. A. & Walter, M. J., Sep 13 2018, In: New England Journal of Medicine. 379, 11, p. 1028-1041 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myelodysplastic Syndromes 100%
  • Transplantation 67%
  • Mutation 49%
  • Gene Frequency 37%
  • Disease Progression 20%
  78 Scopus citations

• Oncogenic Signaling Pathways in The Cancer Genome Atlas

  The Cancer Genome Atlas Research Network, Apr 5 2018, In: Cell. 173, 2, p. 321-337.e10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenic 100%
  • Atlases 76%
  • Mutation 60%
  • Genome 48%
  • Drug 37%
  1549 Scopus citations

• Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

  The Cancer Genome Atlas Network, Mar 28 2018, In: Cell Systems. 6, 3, p. 282-300.e2

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atlases 100%
  • Oncogenes 88%
  • Genome 63%
  • Neoplasms 30%
  • Neoplasm Genes 10%
  210 Scopus citations

• Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 297-312.e12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Genes 100%
  • Long Noncoding RNA 99%
  • Neoplasms 29%
  • MicroRNA 16%
  • RNA-Binding Proteins 6%
  181 Scopus citations

• Pathogenic Germline Variants in 10,389 Adult Cancers

  The Cancer Genome Atlas Research Network, Apr 5 2018, In: Cell. 173, 2, p. 355-370.e14

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • Loss of Heterozygosity 45%
  • Neoplasms 38%
  • Gene Expression 23%
  • Genetic Testing 20%
  458 Scopus citations

• Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

  The Cancer Genome Atlas Research Network, Apr 5 2018, In: Cell. 173, 2, p. 305-320.e10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenic 100%
  • Marking 97%
  • Genomics 72%
  • Mutation 60%
  • Drug 37%
  196 Scopus citations

• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

  MC3 Working Group & The Cancer Genome Atlas Research Network, Mar 28 2018, In: Cell Systems. 6, 3, p. 271-281.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exome 100%
  • Mutation 46%
  • Atlases 39%
  • Neoplasms 26%
  • Genomics 18%
  405 Scopus citations

• Sequencing of tumor DNA to guide cancer risk assessment and therapy

  Spencer, D. H. & Ley, T. J., Apr 10 2018, In: JAMA - Journal of the American Medical Association. 319, 14, p. 1497-1498 2 p.

  Research output: Contribution to journal › Review article › peer-review
  7 Scopus citations

• Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 282-296.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Splicing Factors 100%
  • Mutation 63%
  • Genes 30%
  • Neoplasms 24%
  • RNA Splicing 22%
  245 Scopus citations

• Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 181-193.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • Tumor-Infiltrating Lymphocytes 92%
  • Pathology 46%
  • Neoplasms 20%
  • Tumor Microenvironment 9%
  517 Scopus citations

• Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant

  Jacoby, M. A., Duncavage, E. J., Chang, G. S., Miller, C. A., Shao, J., Elliott, K., Robinson, J., Fulton, R. S., Fronick, C. C., O'Laughlin, M., Heath, S. E., Pusic, I., Welch, J. S., Link, D. C., DiPersio, J. F., Westervelt, P., Ley, T. J., Graubert, T. A. & Walter, M. J., Mar 8 2018, In: JCI Insight. 3, 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myelodysplastic Syndromes 100%
  • Cell Transplantation 95%
  • Allogeneic Cells 95%
  • Transplants 55%
  • Clonal Evolution 17%
  40 Scopus citations

• Systematic Analysis of Splice-Site-Creating Mutations in Cancer

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 270-281.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • Neoplasms 38%
  • Missense Mutation 10%
  • Computational Biology 9%
  • Glioma 9%
  149 Scopus citations

• The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

  The Cancer Genome Atlas Research Network, Apr 3 2018, In: Cell Reports. 23, 1, p. 313-326.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atlases 100%
  • Renal Cell Carcinoma 89%
  • Metabolic 75%
  • Genome 63%
  • Survival 32%
  461 Scopus citations

• The Immune Landscape of Cancer

  The Cancer Genome Atlas Research Network, Apr 17 2018, In: Immunity. 48, 4, p. 812-830.e14

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasms 100%
  • Genetic Epigenesis 49%
  • Lymphocytes 47%
  • Th2 Cells 40%
  • Th1 Cells 39%
  2687 Scopus citations
• 2017

  Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes

  Zhang, J., Griffith, M., Miller, C. A., Griffith, O. L., Spencer, D. H., Walker, J. R., Magrini, V., McGrath, S. D., Ly, A., Helton, N. M., Trissal, M., Link, D. C., Dang, H. X., Larson, D. E., Kulkarni, S., Cordes, M. G., Fronick, C. C., Fulton, R. S., Klco, J. M., Mardis, E. R., & 3 othersLey, T. J., Wilson, R. K. & Maher, C. A., Nov 2017, In: Experimental Hematology. 55, p. 19-33 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Untranslated RNA 100%
  • Myeloid Cells 90%
  • Acute Myeloid Leukemia 84%
  • Transcriptome 81%
  • RNA Sequence Analysis 79%
  9 Scopus citations

• CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression

  Spencer, D. H., Russler-Germain, D. A., Ketkar, S., Helton, N. M., Lamprecht, T. L., Fulton, R. S., Fronick, C. C., O'Laughlin, M., Heath, S. E., Shinawi, M., Westervelt, P., Payton, J. E., Wartman, L. D., Welch, J. S., Wilson, R. K., Walter, M. J., Link, D. C., DiPersio, J. F. & Ley, T. J., Feb 23 2017, In: Cell. 168, 5, p. 801-816.e13

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • CpG Islands 100%
  • Acute Myeloid Leukemia 78%
  • Mutation 69%
  • Methylation 37%
  • hydrogen sulfite 26%
  144 Scopus citations

• Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy

  Uy, G. L., Duncavage, E. J., Chang, G. S., Jacoby, M. A., Miller, C. A., Shao, J., Heath, S., Elliott, K., Reineck, T., Fulton, R. S., Fronick, C. C., O'Laughlin, M., Ganel, L., Abboud, C. N., Cashen, A. F., Dipersio, J. F., Wilson, R. K., Link, D. C., Welch, J. S., Ley, T. J., & 3 othersGraubert, T. A., Westervelt, P. & Walter, M. J., Apr 1 2017, In: Leukemia. 31, 4, p. 872-881 10 p.

  Research output: Contribution to journal › Article › peer-review

  • GATA2 Deficiency 100%
  • Tumor Burden 68%
  • Epigenomics 62%
  • Bone Marrow 52%
  • Panobinostat 28%
  76 Scopus citations

• Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

  Cole, C. B., Russler-Germain, D. A., Ketkar, S., Verdoni, A. M., Smith, A. M., Bangert, C. V., Helton, N. M., Guo, M., Klco, J. M., O'Laughlin, S., Fronick, C., Fulton, R., Chang, G. S., Petti, A. A., Miller, C. A. & Ley, T. J., Oct 2 2017, In: Journal of Clinical Investigation. 127, 10, p. 3657-3674 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA methyltransferase 3A 100%
  • Haploinsufficiency 77%
  • Myeloid Cells 61%
  • Hematopoiesis 26%
  • Hematopoietic Stem Cells 23%
  69 Scopus citations

• Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy

  Duncavage, E. J., Uy, G. L., Petti, A. A., Miller, C. A., Lee, Y. S., Tandon, B., Gao, F., Fronick, C. C., O'Laughlin, M., Fulton, R. S., Wilson, R. K., Jacoby, M. A., Cashen, A. F., Wartman, L. D., Walter, M. J., Westervelt, P., Link, D. C., DiPersio, J. F., Ley, T. J. & Welch, J. S., Mar 9 2017, In: Blood. 129, 10, p. 1397-1401 5 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  19 Scopus citations

• The authors reply

  Welch, J. S., Petti, A. A. & Ley, T. J., Feb 23 2017, In: New England Journal of Medicine. 376, 8, p. 797-798 2 p.

  Research output: Contribution to journal › Letter › peer-review
  26 Scopus citations
• 2016

  Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia

  Griffith, M., Griffith, O. L., Krysiak, K., Skidmore, Z. L., Christopher, M. J., Klco, J. M., Ramu, A., Lamprecht, T. L., Wagner, A. H., Campbell, K. M., Lesurf, R., Hundal, J., Zhang, J., Spies, N. C., Ainscough, B. J., Larson, D. E., Heath, S. E., Fronick, C., O'Laughlin, S., Fulton, R. S., & 17 othersMagrini, V., McGrath, S., Smith, S. M., Miller, C. A., Maher, C. A., Payton, J. E., Walker, J. R., Eldred, J. M., Walter, M. J., Link, D. C., Graubert, T. A., Westervelt, P., Kulkarni, S., DiPersio, J. F., Mardis, E. R., Wilson, R. K. & Ley, T. J., Jul 1 2016, In: Experimental Hematology. 44, 7, p. 603-613 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 100%
  • Genome 46%
  • Recurrence 38%
  • Transcriptome 31%
  • Sunitinib 21%
  41 Scopus citations

• PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia

  Cole, C. B., Verdoni, A. M., Ketkar, S., Leight, E. R., Russler-Germain, D. A., Lamprecht, T. L., Demeter, R. T., Magrini, V. & Ley, T. J., Jan 4 2016, In: Journal of Clinical Investigation. 126, 1, p. 85-98 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA methyltransferase 3A 100%
  • Acute Promyelocytic Leukemia 75%
  • Gene Fusion 45%
  • Methyltransferases 44%
  • Acute Myeloid Leukemia 38%
  32 Scopus citations

• Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML

  Wong, T. N., Miller, C. A., Klco, J. M., Petti, A., Demeter, R., Helton, N. M., Li, T., Fulton, R. S., Heath, S. E., Mardis, E. R., Westervelt, P., Dipersio, J. F., Walter, M. J., Welch, J. S., Graubert, T. A., Wilson, R. K., Ley, T. J. & Link, D. C., Feb 18 2016, In: Blood. 127, 7, p. 893-897 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Induction Chemotherapy 100%
  • Acute Myeloid Leukemia 95%
  • Mutation 84%
  • Clone Cells 79%
  • Clearance 54%
  82 Scopus citations

• Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome

  Duncavage, E. J., O'Brien, J., Vij, K., Miller, C. A., Chang, G. S., Shao, J., Jacoby, M. A., Heath, S., Janke, M. R., Elliott, K., Fulton, R. S., Fronick, C., O'Laughlin, M., Westervelt, P., Ley, T. J., Wilson, R. K. & Walter, M. J., Dec 1 2016, In: Leukemia. 30, 12, p. 2422-2426 5 p.

  Research output: Contribution to journal › Letter › peer-review
  4 Scopus citations

• TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes

  Welch, J. S., Petti, A. A., Miller, C. A., Fronick, C. C., O'Laughlin, M., Fulton, R. S., Wilson, R. K., Baty, J. D., Duncavage, E. J., Tandon, B., Lee, Y. S., Wartman, L. D., Uy, G. L., Ghobadi, A., Tomasson, M. H., Pusic, I., Romee, R., Fehniger, T. A., Stockerl-Goldstein, K. E., Vij, R., & 19 othersOh, S. T., Abboud, C. N., Cashen, A. F., Schroeder, M. A., Jacoby, M. A., Heath, S. E., Luber, K., Janke, M. R., Hantel, A., Khan, N., Sukhanova, M. J., Knoebel, R. W., Stock, W., Graubert, T. A., Walter, M. J., Westervelt, P., Link, D. C., Dipersio, J. F. & Ley, T. J., Nov 24 2016, In: New England Journal of Medicine. 375, 21, p. 2023-2036 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GATA2 Deficiency 100%
  • Decitabine 92%
  • Cytogenetics 22%
  • Mutation 15%
  • Survival Rate 6%
  586 Scopus citations

• Visualizing tumor evolution with the fishplot package for R

  Miller, C. A., McMichael, J., Dang, H. X., Maher, C. A., Ding, L., Ley, T. J., Mardis, E. R. & Wilson, R. K., Nov 7 2016, In: BMC genomics. 17, 1, 880.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Data Visualization 100%
  • High-Throughput Nucleotide Sequencing 65%
  • Publications 56%
  • Neoplasms 44%
  • Therapeutics 11%
  102 Scopus citations
• 2015

  Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia

  Klco, J. M., Miller, C. A., Griffith, M., Petti, A., Spencer, D. H., Ketkar-Kulkarni, S., Wartman, L. D., Christopher, M., Lamprecht, T. L., Helton, N. M., Duncavage, E. J., Payton, J. E., Baty, J., Heath, S. E., Griffith, O. L., Shen, D., Hundal, J., Chang, G. S., Fulton, R., O'Laughlin, M., & 16 othersFronick, C., Magrini, V., Demeter, R. T., Larson, D. E., Kulkarni, S., Ozenberger, B. A., Welch, J. S., Walter, M. J., Graubert, T. A., Westervelt, P., Radich, J. P., Link, D. C., Mardis, E. R., DiPersio, J. F., Wilson, R. K. & Ley, T. J., Aug 25 2015, In: JAMA - Journal of the American Medical Association. 314, 8, p. 811-822 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Myeloid Leukemia 100%
  • Leukemia 85%
  • Mutation 58%
  • High-Throughput Nucleotide Sequencing 22%
  • Bone Marrow Cells 21%
  266 Scopus citations

• Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia

  Engle, E. K., Fisher, D. A. C., Miller, C. A., McLellan, M. D., Fulton, R. S., Moore, D. M., Wilson, R. K., Ley, T. J. & Oh, S. T., Apr 15 2015, In: Leukemia. 29, 4, p. 869-876 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clonal Evolution 100%
  • Primary Myelofibrosis 90%
  • Whole Genome Sequencing 83%
  • Acute Myeloid Leukemia 68%
  • Clone Cells 28%
  40 Scopus citations

• Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

  Spencer, D. H., Young, M. A., Lamprecht, T. L., Helton, N. M., Fulton, R., O'Laughlin, M., Fronick, C., Magrini, V., Demeter, R. T., Miller, C. A., Klco, J. M., Wilson, R. K. & Ley, T. J., Jun 9 2015, In: Leukemia. 29, 6, p. 1279-1289 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Myeloid Leukemia 100%
  • Epigenomics 91%
  • Genes 42%
  • Hematopoietic Stem Cells 25%
  • RNA Sequence Analysis 14%
  78 Scopus citations

• Genetic heterogeneity of induced pluripotent stem cells: Results from 24 clones derived from a single C57BL/6 mouse

  Li, C., Klco, J. M., Helton, N. M., George, D. R., Mudd, J. L., Miller, C. A., Lu, C., Fulton, R., O'Laughlin, M., Fronick, C., Wilson, R. K. & Ley, T. J., Mar 23 2015, In: PloS one. 10, 3, e0120585.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • induced pluripotent stem cells 100%
  • Genetic Heterogeneity 75%
  • Induced Pluripotent Stem Cells 72%
  • Inbred C57BL Mouse 60%
  • Heterogeneity 59%
  11 Scopus citations