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Timothy Ley

Lewis T and Rosalind B Apple Professor of Medicine, Professor of Genetics

    • 44864 Citations
    1982 …2020

    Research output per year

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    Personal profile

    Research interests

    Thalassemia; Sickle Cell Anemia

    Areas of Clinical Interest

    Hemoglobinopathies, acute and chronic myeloid leukemias, cancer genomis, cytotoxic lymphocytes

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    Research Output

    Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression

    Silva-Fisher, J. M., Dang, H. X., White, N. M., Strand, M. S., Krasnick, B. A., Rozycki, E. B., Jeffers, G. G. L., Grossman, J. G., Highkin, M. K., Tang, C., Cabanski, C. R., Eteleeb, A., Mudd, J., Goedegebuure, S. P., Luo, J., Mardis, E. R., Wilson, R. K., Ley, T. J., Lockhart, A. C., Fields, R. C. & 1 others, Maher, C. A., Dec 1 2020, In : Nature communications. 11, 1, 2156.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Obesity is a risk factor for acute promyelocytic leukemia: Evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism

    Mazzarella, L., Botteri, E., Matthews, A., Gatti, E., Di Salvatore, D., Bagnardi, V., Breccia, M., Montesinos, P., Bernal, T., Gil, C., Ley, T. J., Sanz, M., Bhaskaran, K., Coco, F. L. & Pelicci, P. G., Jun 1 2020, In : Haematologica. 105, 6, p. 1559-1566 8 p.

    Research output: Contribution to journal › Article

    Open Access

    • Pan-cancer analysis of whole genomes

    The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 6 2020, In : Nature. 578, 7793, p. 82-93 12 p.

    Research output: Contribution to journal › Article

    Open Access
    • 125 Scopus citations

    Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing

    Ketkar, S., Verdoni, A. M., Smith, A. M., Bangert, C. V., Leight, E. R., Chen, D. Y., Brune, M. K., Helton, N. M., Hoock, M., George, D. R., Fronick, C., Fulton, R. S., Ramakrishnan, S. M., Chang, G. S., Petti, A. A., Spencer, D. H., Miller, C. A. & Ley, T. J., Feb 11 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3123-3134 12 p.

    Research output: Contribution to journal › Article

    Open Access

    • The clonal evolution of metastatic colorectal cancer

    Dang, H. X., Krasnick, B. A., White, B. S., Grossman, J. G., Strand, M. S., Zhang, J., Cabanski, C. R., Miller, C. A., Fulton, R. S., Goedegebuure, S. P., Fronick, C. C., Griffith, M., Larson, D. E., Goetz, B. D., Walker, J. R., Hawkins, W. G., Strasberg, S. M., Linehan, D. C., Lim, K. H., Lockhart, A. C. & 5 others, Mardis, E. R., Wilson, R. K., Ley, T. J., Maher, C. A. & Fields, R. C., Jun 2020, In : Science Advances. 6, 24, eaay9691.

    Research output: Contribution to journal › Article

    Open Access