Research output per year
Research output per year
- 39 results
Search results
-
2024
Generation of 3D Trophoblast Organoids from Human Naïve Pluripotent Stem Cells
Karvas, R. M. & Theunissen, T. W., 2024, Methods in Molecular Biology. Humana Press Inc., p. 85-103 19 p. (Methods in Molecular Biology; vol. 2767).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access2 Scopus citations -
iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation
Morey, R., Bui, T., Cheung, V. C., Dong, C., Zemke, J. E., Requena, D., Arora, H., Jackson, M. G., Pizzo, D., Theunissen, T. W. & Horii, M., Apr 19 2024, In: iScience. 27, 4, 109569.Research output: Contribution to journal › Article › peer-review
Open Access -
Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously
Guo, M., Wu, J., Chen, C., Wang, X., Gong, A., Guan, W., Karvas, R. M., Wang, K., Min, M., Wang, Y., Theunissen, T. W., Gao, S. & Silva, J. C. R., Dec 2024, In: Nature communications. 15, 1, 668.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2023
3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages
Karvas, R. M., Zemke, J. E., Ali, S. S., Upton, E., Sane, E., Fischer, L. A., Dong, C., Park, K. M., Wang, F., Park, K., Hao, S., Chew, B., Meyer, B., Zhou, C., Dietmann, S. & Theunissen, T. W., Sep 7 2023, In: Cell Stem Cell. 30, 9, p. 1148-1165.e7Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Modeling X-chromosome inactivation and reactivation during human development
Khan, S. A. & Theunissen, T. W., Oct 2023, In: Current Opinion in Genetics and Development. 82, 102096.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
2022
Accessing the human trophoblast stem cell state from pluripotent and somatic cells
Karvas, R. M., David, L. & Theunissen, T. W., Dec 2022, In: Cellular and Molecular Life Sciences. 79, 12, 604.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells
Dong, C., Fu, S., Karvas, R. M., Chew, B., Fischer, L. A., Xing, X., Harrison, J. K., Popli, P., Kommagani, R., Wang, T., Zhang, B. & Theunissen, T. W., Dec 2022, In: Nature communications. 13, 1, 2548.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Generating Trophoblast Stem Cells from Human Naïve Pluripotent Stem Cells
Dong, C. & Theunissen, T. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 91-104 14 p. (Methods in Molecular Biology; vol. 2416).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
8 Scopus citations -
Induction of Human Naïve Pluripotency Using 5i/L/A Medium
Fischer, L. A., Khan, S. A. & Theunissen, T. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 13-28 16 p. (Methods in Molecular Biology; vol. 2416).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access9 Scopus citations -
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens
Karvas, R. M., Khan, S. A., Verma, S., Yin, Y., Kulkarni, D., Dong, C., Park, K. M., Chew, B., Sane, E., Fischer, L. A., Kumar, D., Ma, L., Boon, A. C. M., Dietmann, S., Mysorekar, I. U. & Theunissen, T. W., May 5 2022, In: Cell Stem Cell. 29, 5, p. 810-825.e8Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
2021
OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
Huang, X., Park, K. M., Gontarz, P., Zhang, B., Pan, J., McKenzie, Z., Fischer, L. A., Dong, C., Dietmann, S., Xing, X., Shliaha, P. V., Yang, J., Li, D., Ding, J., Lungjangwa, T., Mitalipova, M., Khan, S. A., Imsoonthornruksa, S., Jensen, N. & Wang, T. & 4 others, , Dec 1 2021, In: Nature communications. 12, 1, 5123.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
Khan, S. A., Park, K. M., Fischer, L. A., Dong, C., Lungjangwa, T., Jimenez, M., Casalena, D., Chew, B., Dietmann, S., Auld, D. S., Jaenisch, R. & Theunissen, T. W., Jun 15 2021, In: Cell Reports. 35, 11, 109233.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2020
Derivation of trophoblast stem cells from naïve human pluripotent stem cells
Dong, C., Beltcheva, M., Gontarz, P., Zhang, B., Popli, P., Fischer, L. A., Khan, S. A., Park, K. M., Yoon, E. J., Xing, X., Kommagani, R., Wang, T., Solnica-Krezel, L. & Theunissen, T. W., Feb 2020, In: eLife. 9, e52504.Research output: Contribution to journal › Article › peer-review
Open Access192 Scopus citations -
2019
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
Pontis, J., Planet, E., Offner, S., Turelli, P., Duc, J., Coudray, A., Theunissen, T. W., Jaenisch, R. & Trono, D., May 2 2019, In: Cell Stem Cell. 24, 5, p. 724-735.e5Research output: Contribution to journal › Article › peer-review
Open Access157 Scopus citations -
Recent insights into the naïve state of human pluripotency and its applications
Dong, C., Fischer, L. A. & Theunissen, T. W., Dec 1 2019, In: Experimental Cell Research. 385, 1, 111645.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Zmym2 inhibits nanog-mediated reprogramming
Lawrence, M., Theunissen, T. W., Lombard, P., Adams, D. J. & Silva, J. C. R., 2019, In: Wellcome Open Research. 4, 88.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2017
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation
Sahakyan, A., Kim, R., Chronis, C., Sabri, S., Bonora, G., Theunissen, T. W., Kuoy, E., Langerman, J., Clark, A. T., Jaenisch, R. & Plath, K., Jan 5 2017, In: Cell Stem Cell. 20, 1, p. 87-101 15 p.Research output: Contribution to journal › Article › peer-review
Open Access170 Scopus citations -
Mechanisms of gene regulation in human embryos and pluripotent stem cells
Theunissen, T. W. & Jaenisch, R., Dec 15 2017, In: Development (Cambridge). 144, 24, p. 4496-4509 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access57 Scopus citations -
2016
Molecular Criteria for Defining the Naive Human Pluripotent State
Theunissen, T. W., Friedli, M., He, Y., Planet, E., O'Neil, R. C., Markoulaki, S., Pontis, J., Wang, H., Iouranova, A., Imbeault, M., Duc, J., Cohen, M. A., Wert, K. J., Castanon, R., Zhang, Z., Huang, Y., Nery, J. R., Drotar, J., Lungjangwa, T. & Trono, D. & 2 others, , Oct 6 2016, In: Cell Stem Cell. 19, 4, p. 502-515 14 p.Research output: Contribution to journal › Article › peer-review
Open Access359 Scopus citations -
2015
Failure to replicate the STAP cell phenomenon
De Los Angeles, A., Ferrari, F., Fujiwara, Y., Mathieu, R., Lee, S., Lee, S., Tu, H. C., Ross, S., Chou, S., Nguyen, M., Wu, Z., Theunissen, T. W., Powell, B. E., Imsoonthornruksa, S., Chen, J., Borkent, M., Krupalnik, V., Lujan, E., Wernig, M. & Hanna, J. H. & 7 others, , Sep 24 2015, In: Nature. 525, 7570, p. E6-E9Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
2014
Erratum: Systematic identification of culture conditions for induction and maintenance of naive human pluripotency (Cell Stem Cell (2014) 15 (471-487))
Theunissen, T. W., Powell, B. E., Wang, H., Mitalipova, M., Faddah, D. A., Reddy, J., Fan, Z. P., Maetzel, D., Ganz, K., Shi, L., Lungjangwa, T., Imsoonthornruksa, S., Stelzer, Y., Rangarajan, S., D'Alessio, A., Zhang, J., Gao, Q., Dawlaty, M. M., Young, R. A. & Gray, N. S. & 1 others, , 2014, In: Cell Stem Cell. 15, 4, p. 524-526 3 p.Research output: Contribution to journal › Comment/debate
Open Access68 Scopus citations -
Erratum: Systematic identification of culture conditions for induction and maintenance of naive human pluripotency (Cell Stem Cell (2014) 15 (471-487))
Theunissen, T. W., Powell, B. E., Wang, H., Mitalipova, M., Faddah, D. A., Reddy, J., Fan, Z. P., Maetzel, D., Ganz, K., Shi, L., Lungjangwa, T., Imsoonthornruksa, S., Stelzer, Y., Rangarajan, S., D'Alessio, A., Zhang, J., Gao, Q., Dawlaty, M. M., Young, R. A. & Gray, N. S. & 1 others, , 2014, In: Cell Stem Cell. 15, 4, p. 523 1 p.Research output: Contribution to journal › Comment/debate
Open Access7 Scopus citations -
Molecular control of induced pluripotency
Theunissen, T. W. & Jaenisch, R., Jun 5 2014, In: Cell Stem Cell. 14, 6, p. 720-734 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access111 Scopus citations -
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
Theunissen, T. W., Powell, B. E., Wang, H., Mitalipova, M., Faddah, D. A., Reddy, J., Fan, Z. P., Maetzel, D., Ganz, K., Shi, L., Lungjangwa, T., Imsoonthornruksa, S., Stelzer, Y., Rangarajan, S., D'Alessio, A., Zhang, J., Gao, Q., Dawlaty, M. M., Young, R. A. & Gray, N. S. & 1 others, , 2014, In: Cell Stem Cell. 15, 4, p. 471-487 17 p.Research output: Contribution to journal › Article › peer-review
Open Access625 Scopus citations -
2013
A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages
Radzisheuskaya, A., Le Bin Chia, G., Dos Santos, R. L., Theunissen, T. W., Castro, L. F. C., Nichols, J. & Silva, J. C. R., Jun 2013, In: Nature Cell Biology. 15, 6, p. 579-590 12 p.Research output: Contribution to journal › Article › peer-review
Open Access163 Scopus citations -
Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3
Przybyla, L. M., Theunissen, T. W., Jaenisch, R. & Voldman, J., Jun 2013, In: STEM CELLS. 31, 6, p. 1097-1106 10 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
Cheng, A. W., Wang, H., Yang, H., Shi, L., Katz, Y., Theunissen, T. W., Rangarajan, S., Shivalila, C. S., Dadon, D. B. & Jaenisch, R., Oct 2013, In: Cell Research. 23, 10, p. 1163-1171 9 p.Research output: Contribution to journal › Article › peer-review
Open Access620 Scopus citations -
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency
Costa, Y., Ding, J., Theunissen, T. W., Faiola, F., Hore, T. A., Shliaha, P. V., Fidalgo, M., Saunders, A., Lawrence, M., Dietmann, S., Das, S., Levasseur, D. N., Li, Z., Xu, M., Reik, W., Silva, J. C. R. & Wang, J., Mar 21 2013, In: Nature. 495, 7441, p. 370-374 5 p.Research output: Contribution to journal › Article › peer-review
Open Access353 Scopus citations -
2012
Somatic cell reprogramming: Role of homeodomain protein nanog
Theunissen, T. W. & Silva, J. C. R., Jan 1 2012, Stem Cells and Cancer Stem Cells. Springer Netherlands, p. 377-384 8 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
2011
Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions
Theunissen, T. W., Van Oosten, A. L., Castelo-Branco, G., Hall, J., Smith, A. & Silva, J. C. R., Jan 11 2011, In: Current Biology. 21, 1, p. 65-71 7 p.Research output: Contribution to journal › Article › peer-review
Open Access140 Scopus citations -
Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain
Theunissen, T. W., Costa, Y., Radzisheuskaya, A., van Oosten, A. L., Lavial, F., Pain, B., Castro, L. F. C. & Silva, J. C. R., Nov 15 2011, In: Development. 138, 22, p. 4853-4865 13 p.Research output: Contribution to journal › Article › peer-review
Open Access68 Scopus citations -
Switching on pluripotency: A perspective on the biological requirement of Nanog
Theunissen, T. W. & Silva, J. C. R., Jul 4 2011, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 366, 1575, p. 2222-2229 8 p.Research output: Contribution to journal › Review article › peer-review
33 Scopus citations -
2010
Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency
Tee, W. W., Pardo, M., Theunissen, T. W., Yu, L., Choudhary, J. S., Hajkova, P. & Surani, M. A., Dec 15 2010, In: Genes and Development. 24, 24, p. 2772-2777 6 p.Research output: Contribution to journal › Article › peer-review
Open Access264 Scopus citations -
Stat3 activation is limiting for reprogramming to ground state pluripotency
Yang, J., Van Oosten, A. L., Theunissen, T. W., Guo, G., Silva, J. C. R. & Smith, A., Sep 3 2010, In: Cell Stem Cell. 7, 3, p. 319-328 10 p.Research output: Contribution to journal › Article › peer-review
Open Access196 Scopus citations -
2009
Nanog Is the Gateway to the Pluripotent Ground State
Silva, J., Nichols, J., Theunissen, T. W., Guo, G., van Oosten, A. L., Barrandon, O., Wray, J., Yamanaka, S., Chambers, I. & Smith, A., Aug 21 2009, In: Cell. 138, 4, p. 722-737 16 p.Research output: Contribution to journal › Article › peer-review
Open Access825 Scopus citations -
2008
Promotion of reprogramming to ground state pluripotency by signal inhibition
Silva, J., Barrandon, O., Nichols, J., Kawaguchi, J., Theunissen, T. W. & Smith, A., Oct 2008, In: PLoS biology. 6, 10, p. 2237-2247 11 p., e253.Research output: Contribution to journal › Article › peer-review
Open Access688 Scopus citations -
The transcriptional network controlling pluripotency in ES cells
Orkin, S. H., Wang, J., Kim, J., Chu, J., Rao, S., Theunissen, T. W., Shen, X. & Levasseur, D. N., 2008, In: Cold Spring Harbor symposia on quantitative biology. 73, p. 195-202 8 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
2007
Site-directed, virus-free, and inducible RNAi in embryonic stem cells
Wang, J., Theunissen, T. W. & Orkin, S. H., Dec 26 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20850-20855 6 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2006
A protein interaction network for pluripotency of embryonic stem cells
Wang, J., Rao, S., Chu, J., Shen, X., Levasseur, D. N., Theunissen, T. W. & Orkin, S. H., Nov 16 2006, In: Nature. 444, 7117, p. 364-368 5 p.Research output: Contribution to journal › Article › peer-review
935 Scopus citations