Research output per year
Research output per year
Personal profile
Research interests
Research in my laboratory is dedicated to exploring the molecular regulation and applications of pluripotent stem cells. I have developed culture conditions for the generation of “naive” pluripotent stem cells that closely resemble pluripotent cells in the human blastocyst in vivo based on transcriptional and epigenetic criteria. My laboratory investigates the signaling requirements for naive pluripotent stem cells, as a basis for improving their long-term genetic and epigenetic stability. We also seek to leverage the unique properties of naive stem cells to better model early human development and X-linked diseases, and compare the differentiation potential of distinct stem cell states.
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A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells
Dong, C., Fu, S., Karvas, R. M., Chew, B., Fischer, L. A., Xing, X., Harrison, J. K., Popli, P., Kommagani, R., Wang, T., Zhang, B. & Theunissen, T. W., Dec 2022, In: Nature communications. 13, 1, 2548.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Generating Trophoblast Stem Cells from Human Naïve Pluripotent Stem Cells
Dong, C. & Theunissen, T. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 91-104 14 p. (Methods in Molecular Biology; vol. 2416).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
4 Scopus citations -
Induction of Human Naïve Pluripotency Using 5i/L/A Medium
Fischer, L. A., Khan, S. A. & Theunissen, T. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 13-28 16 p. (Methods in Molecular Biology; vol. 2416).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens
Karvas, R. M., Khan, S. A., Verma, S., Yin, Y., Kulkarni, D., Dong, C., Park, K. M., Chew, B., Sane, E., Fischer, L. A., Kumar, D., Ma, L., Boon, A. C. M., Dietmann, S., Mysorekar, I. U. & Theunissen, T. W., May 5 2022, In: Cell Stem Cell. 29, 5, p. 810-825.e8Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
Huang, X., Park, K. M., Gontarz, P., Zhang, B., Pan, J., McKenzie, Z., Fischer, L. A., Dong, C., Dietmann, S., Xing, X., Shliaha, P. V., Yang, J., Li, D., Ding, J., Lungjangwa, T., Mitalipova, M., Khan, S. A., Imsoonthornruksa, S., Jensen, N., Wang, T., & 4 others, Dec 1 2021, In: Nature communications. 12, 1, 5123.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations