Research output per year
Research output per year
Personal profile
Research interests
Research in my laboratory is dedicated to exploring the molecular regulation and applications of pluripotent stem cells. I have developed culture conditions for the generation of “naive” pluripotent stem cells that closely resemble pluripotent cells in the human blastocyst in vivo based on transcriptional and epigenetic criteria. My laboratory investigates the signaling requirements for naive pluripotent stem cells, as a basis for improving their long-term genetic and epigenetic stability. We also seek to leverage the unique properties of naive stem cells to better model early human development and X-linked diseases, and compare the differentiation potential of distinct stem cell states.
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Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
Khan, S. A., Park, K. M., Fischer, L. A., Dong, C., Lungjangwa, T., Jimenez, M., Casalena, D., Chew, B., Dietmann, S., Auld, D. S., Jaenisch, R. & Theunissen, T. W., Jun 15 2021, In: Cell Reports. 35, 11, 109233.Research output: Contribution to journal › Article › peer-review
Open Access -
Derivation of trophoblast stem cells from naïve human pluripotent stem cells
Dong, C., Beltcheva, M., Gontarz, P., Zhang, B., Popli, P., Fischer, L. A., Khan, S. A., Park, K. M., Yoon, E. J., Xing, X., Kommagani, R., Wang, T., Solnica-Krezel, L. & Theunissen, T. W., Feb 2020, In: eLife. 9, e52504.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
Pontis, J., Planet, E., Offner, S., Turelli, P., Duc, J., Coudray, A., Theunissen, T. W., Jaenisch, R. & Trono, D., May 2 2019, In: Cell Stem Cell. 24, 5, p. 724-735.e5Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Recent insights into the naïve state of human pluripotency and its applications
Dong, C., Fischer, L. A. & Theunissen, T. W., Dec 1 2019, In: Experimental Cell Research. 385, 1, 111645.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Zmym2 inhibits nanog-mediated reprogramming
Lawrence, M., Theunissen, T. W., Lombard, P., Adams, D. J. & Silva, J. C. R., 2019, In: Wellcome Open Research. 4, 88.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations