• 4503 Citations

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Research in my laboratory is dedicated to exploring the molecular regulation and applications of pluripotent stem cells. I have developed culture conditions for the generation of “naive” pluripotent stem cells that closely resemble pluripotent cells in the human blastocyst in vivo based on transcriptional and epigenetic criteria. My laboratory investigates the signaling requirements for naive pluripotent stem cells, as a basis for improving their long-term genetic and epigenetic stability. We also seek to leverage the unique properties of naive stem cells to better model early human development and X-linked diseases, and compare the differentiation potential of distinct stem cell states.

Fingerprint Dive into the research topics where Thorold Theunissen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

  • 4503 Citations
  • 21 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

Dong, C., Beltcheva, M., Gontarz, P., Zhang, B., Popli, P., Fischer, L. A., Khan, S. A., Park, K. M., Yoon, E. J., Xing, X., Kommagani, R., Wang, T., Solnica-Krezel, L. & Theunissen, T. W., Feb 2020, In : eLife. 9, e52504.

Research output: Contribution to journalArticle

Open Access
  • 9 Scopus citations

    Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

    Pontis, J., Planet, E., Offner, S., Turelli, P., Duc, J., Coudray, A., Theunissen, T. W., Jaenisch, R. & Trono, D., May 2 2019, In : Cell Stem Cell. 24, 5, p. 724-735.e5

    Research output: Contribution to journalArticle

    Open Access
  • 32 Scopus citations

    Recent insights into the naïve state of human pluripotency and its applications

    Dong, C., Fischer, L. A. & Theunissen, T. W., Dec 1 2019, In : Experimental Cell Research. 385, 1, 111645.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Zmym2 inhibits nanog-mediated reprogramming

    Lawrence, M., Theunissen, T. W., Lombard, P., Adams, D. J. & Silva, J. C. R., 2019, In : Wellcome Open Research. 4, 88.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation

    Sahakyan, A., Kim, R., Chronis, C., Sabri, S., Bonora, G., Theunissen, T. W., Kuoy, E., Langerman, J., Clark, A. T., Jaenisch, R. & Plath, K., Jan 5 2017, In : Cell Stem Cell. 20, 1, p. 87-101 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 87 Scopus citations