Research output per year
Research output per year
Personal profile
Research interests
Research in my laboratory is dedicated to exploring the molecular regulation and applications of pluripotent stem cells. I have developed culture conditions for the generation of “naive” pluripotent stem cells that closely resemble pluripotent cells in the human blastocyst in vivo based on transcriptional and epigenetic criteria. My laboratory investigates the signaling requirements for naive pluripotent stem cells, as a basis for improving their long-term genetic and epigenetic stability. We also seek to leverage the unique properties of naive stem cells to better model early human development and X-linked diseases, and compare the differentiation potential of distinct stem cell states.
Mentoring
Dr. Theunissen has completed formal mentorship training through the University of Minnesota's Clinical and Translational Science Institute in 2024.
Available to Mentor:
- PhD/MSTP Students
- High School Students
- Undergraduate Students
- Post-Baccalaureate Students
- Postdocs
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Erratum: Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions (Neuron (2024) 112(17) (2886–2909.e16), (S0896627324004094), (10.1016/j.neuron.2024.06.002))
Lam, I., Ndayisaba, A., Lewis, A. J., Fu, Y. H., Sagredo, G. T., Kuzkina, A., Zaccagnini, L., Celikag, M., Sandoe, J., Sanz, R. L., Vahdatshoar, A., Martin, T. D., Morshed, N., Ichihashi, T., Tripathi, A., Ramalingam, N., Oettgen-Suazo, C., Bartels, T., Boussouf, M. & Schäbinger, M. & 34 others, , Feb 19 2025, In: Neuron. 113, 4, p. 637 1 p.Research output: Contribution to journal › Comment/debate
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Stem cell models of human embryo implantation and trophoblast invasion
Liu, P., Mattis, S. & Theunissen, T. W., Aug 2025, In: Current Opinion in Genetics and Development. 93, 102357.Research output: Contribution to journal › Review article › peer-review
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Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution
Fischer, L. A., Meyer, B., Reyes, M., Zemke, J. E., Harrison, J. K., Park, K. M., Wang, T., Jüppner, H., Dietmann, S. & Theunissen, T. W., Mar 11 2025, In: Stem Cell Reports. 20, 3, 102419.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Generation of 3D Trophoblast Organoids from Human Naïve Pluripotent Stem Cells
Karvas, R. M. & Theunissen, T. W., 2024, Methods in Molecular Biology. Humana Press Inc., p. 85-103 19 p. (Methods in Molecular Biology; vol. 2767).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access2 Scopus citations -
iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation
Morey, R., Bui, T., Cheung, V. C., Dong, C., Zemke, J. E., Requena, D., Arora, H., Jackson, M. G., Pizzo, D., Theunissen, T. W. & Horii, M., Apr 19 2024, In: iScience. 27, 4, 109569.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations