Research in my laboratory is dedicated to exploring the molecular regulation and applications of pluripotent stem cells. I have developed culture conditions for the generation of “naive” pluripotent stem cells that closely resemble pluripotent cells in the human blastocyst in vivo based on transcriptional and epigenetic criteria. My laboratory investigates the signaling requirements for naive pluripotent stem cells, as a basis for improving their long-term genetic and epigenetic stability. We also seek to leverage the unique properties of naive stem cells to better model early human development and X-linked diseases, and compare the differentiation potential of distinct stem cell states.

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