Research output per year
Research output per year
Personal profile
Research interests
Research in my laboratory is dedicated to exploring the molecular regulation and applications of pluripotent stem cells. I have developed culture conditions for the generation of “naive” pluripotent stem cells that closely resemble pluripotent cells in the human blastocyst in vivo based on transcriptional and epigenetic criteria. My laboratory investigates the signaling requirements for naive pluripotent stem cells, as a basis for improving their long-term genetic and epigenetic stability. We also seek to leverage the unique properties of naive stem cells to better model early human development and X-linked diseases, and compare the differentiation potential of distinct stem cell states.
Fingerprint
Dive into the research topics where Thorold Theunissen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 6 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research output
-
Derivation of trophoblast stem cells from naïve human pluripotent stem cells
Dong, C., Beltcheva, M., Gontarz, P., Zhang, B., Popli, P., Fischer, L. A., Khan, S. A., Park, K. M., Yoon, E. J., Xing, X., Kommagani, R., Wang, T., Solnica-Krezel, L. & Theunissen, T. W., Feb 2020, In: eLife. 9, e52504.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
Pontis, J., Planet, E., Offner, S., Turelli, P., Duc, J., Coudray, A., Theunissen, T. W., Jaenisch, R. & Trono, D., May 2 2019, In: Cell Stem Cell. 24, 5, p. 724-735.e5Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Recent insights into the naïve state of human pluripotency and its applications
Dong, C., Fischer, L. A. & Theunissen, T. W., Dec 1 2019, In: Experimental Cell Research. 385, 1, 111645.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Zmym2 inhibits nanog-mediated reprogramming
Lawrence, M., Theunissen, T. W., Lombard, P., Adams, D. J. & Silva, J. C. R., 2019, In: Wellcome Open Research. 4, 88.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation
Sahakyan, A., Kim, R., Chronis, C., Sabri, S., Bonora, G., Theunissen, T. W., Kuoy, E., Langerman, J., Clark, A. T., Jaenisch, R. & Plath, K., Jan 5 2017, In: Cell Stem Cell. 20, 1, p. 87-101 15 p.Research output: Contribution to journal › Article › peer-review
Open Access102 Scopus citations