Thomas Girard

2024

Deletion of tissue factor pathway inhibitor isoform beta or gamma, but not alpha, improves clotting in hemophilic mice

Eldem, I., Antunes-Heck, L., Subramanian, R., Lasky, N. M., Ashworth, K., Di Paola, J. & Girard, T. J., Oct 2024, In: Journal of Thrombosis and Haemostasis. 22, 10, p. 2681-2691 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

D-dimer predicts venous thromboembolism in multiple myeloma: a nested case-control study

Sanfilippo, K. M., Fiala, M. A., Feinberg, D., Tathireddy, H., Girard, T., Vij, R., Di Paola, J. & Gage, B. F., Nov 2023, In: Research and Practice in Thrombosis and Haemostasis. 7, 8, 102235.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease

Girard, T. J., Antunes, L., Zhang, N., Amrute, J. M., Subramanian, R., Eldem, I., Remy, K., Mazer, M., Erlich, E. C., Cruchaga, C., Steed, A. L., Randolph, G. J. & Di Paola, J., Mar 2023, In: Journal of Thrombosis and Haemostasis. 21, 3, p. 629-638 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2019

George J. Broze Jr., MD (3 August 1946-19 June 2019)

Gailani, D., Girard, T. J. & Mast, A. E., Oct 1 2019, In: Journal of thrombosis and haemostasis : JTH. 17, 10, p. 1779-1780 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Suppressing protein Z-dependent inhibition of factor Xa improves coagulation in hemophilia A

Girard, T. J., Lasky, N. M., Grunz, K. & Broze, G. J., Jan 2019, In: Journal of Thrombosis and Haemostasis. 17, 1, p. 149-156 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2018

Re-evaluation of mouse tissue factor pathway inhibitor and comparison of mouse and human tissue factor pathway inhibitor physiology

Girard, T. J., Grunz, K., Lasky, N. M., Malone, J. P. & Broze, G. J., Nov 2018, In: Journal of Thrombosis and Haemostasis. 16, 11, p. 2246-2257 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2013

Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response

Girard, T. J., Lasky, N. M., Tuley, E. A. & Broze, G. J., Feb 2013, In: Journal of Thrombosis and Haemostasis. 11, 2, p. 375-378 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2012

TFPIβ is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes

Girard, T. J., Tuley, E. & Broze, G. J., Feb 2 2012, In: Blood. 119, 5, p. 1256-1262 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Tissue factor pathway inhibitor: Structure-function

Broze, G. J. & Girard, T. J., Jan 1 2012, In: Frontiers in Bioscience. 17, 1, p. 262-280 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

139 Scopus citations

2010

Part II: Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y₁₂ antagonists for inhibition of platelet aggregation

Parlow, J. J., Burney, M. W., Case, B. L., Girard, T. J., Hall, K. A., Harris, P. K., Hiebsch, R. R., Huff, R. M., Lachance, R. M., Mischke, D. A., Rapp, S. R., Woerndle, R. S. & Ennis, M. D., Feb 15 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 4, p. 1388-1394 7 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Piperazinyl glutamate pyridines as potent orally bioavailable P2Y ₁₂ antagonists for inhibition of platelet aggregation

Parlow, J. J., Burney, M. W., Case, B. L., Girard, T. J., Hall, K. A., Harris, P. K., Hiebsch, R. R., Huff, R. M., Lachance, R. M., Mischke, D. A., Rapp, S. R., Woerndle, R. S. & Ennis, M. D., Mar 11 2010, In: Journal of Medicinal Chemistry. 53, 5, p. 2010-2037 28 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

2009

Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y₁₂ antagonists for inhibition of platelet aggregation

Parlow, J. J., Burney, M. W., Case, B. L., Girard, T. J., Hall, K. A., Hiebsch, R. R., Huff, R. M., Lachance, R. M., Mischke, D. A., Rapp, S. R., Woerndle, R. S. & Ennis, M. D., Aug 15 2009, In: Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4657-4663 7 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Piperazinyl-glutamate-pyrimidines as potent P2Y₁₂ antagonists for inhibition of platelet aggregation

Parlow, J. J., Burney, M. W., Case, B. L., Girard, T. J., Hall, K. A., Hiebsch, R. R., Huff, R. M., Lachance, R. M., Mischke, D. A., Rapp, S. R., Woerndle, R. S. & Ennis, M. D., Nov 1 2009, In: Bioorganic and Medicinal Chemistry Letters. 19, 21, p. 6148-6156 9 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2003

Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex

Parlow, J. J., Case, B. L., Dice, T. A., Fenton, R. L., Hayes, M. J., Jones, D. E., Neumann, W. L., Wood, R. S., Lachance, R. M., Girard, T. J., Nicholson, N. S., Clare, M., Stegeman, R. A., Stevens, A. M., Stallings, W. C., Kurumbail, R. G. & South, M. S., Sep 11 2003, In: Journal of Medicinal Chemistry. 46, 19, p. 4050-4062 13 p.

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Polymer-Assisted Solution-Phase (PASP) parallel synthesis of an α-ketothiazole library as tissue factor VIIa inhibitors

South, M. S., Dice, T. A., Girard, T. J., Lachance, R. M., Stevens, A. M., Stegeman, R. A., Stallings, W. C., Kurumbail, R. G. & Parlow, J. J., Jul 21 2003, In: Bioorganic and Medicinal Chemistry Letters. 13, 14, p. 2363-2367 5 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Polymer-assisted solution-phase library synthesis and crystal structure of α-ketothiazoles as tissue factor VIIa inhibitors

Parlow, J. J., Dice, T. A., Lachance, R. M., Girard, T. J., Stevens, A. M., Stegeman, R. A., Stallings, W. C., Kurumbail, R. G. & South, M. S., Sep 11 2003, In: Journal of Medicinal Chemistry. 46, 19, p. 4043-4049 7 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex

South, M. S., Case, B. L., Wood, R. S., Jones, D. E., Hayes, M. J., Girard, T. J., Lachance, R. M., Nicholson, N. S., Clare, M., Stevens, A. M., Stegeman, R. A., Stallings, W. C., Kurumbail, R. G. & Parlow, J. J., Jul 21 2003, In: Bioorganic and Medicinal Chemistry Letters. 13, 14, p. 2319-2325 7 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

2002

Pharmacological intervention at disparate sites in the coagulation cascade: Comparison of anti-thrombotic efficacy vs. bleeding propensity in a rat model of acute arterial thrombosis

Szalony, J. A., Taite, B. B., Girard, T. J., Nicholson, N. S. & LaChance, R. M., Oct 2002, In: Journal of Thrombosis and Thrombolysis. 14, 2, p. 113-121 9 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

1999

Structural requirements for TFPI-mediated inhibition of neointimal thickening after balloon injury in the rat

Han, X., Girard, T. J., Baum, P., Abendschein, D. R. & Broze, G. J., Oct 1999, In: Arteriosclerosis, thrombosis, and vascular biology. 19, 10, p. 2563-2567 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

1998

Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex

Wang, D., Girard, T. J., Kasten, T. P., LaChance, R. M., Miller-Wideman, M. A. & Durley, R. C., Nov 1998, In: Journal of Natural Products. 61, 11, p. 1352-1355 4 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

1995

Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation

Cross, A. H., Girard, T. J., Giacoletto, K. S., Evans, R. J., Keeling, R. M., Lin, R. F., Trotter, J. L. & Karr, R. W., Jun 1995, In: Journal of Clinical Investigation. 95, 6, p. 2783-2789 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Scopus citations

1994

Complementary DNA sequencing of canine tissue factor pathway inhibitor reveals a unique nanomeric repetitive sequence between the second and third Kunitz domains

Girard, T. J., Gailani, D. & Broze, G. J., 1994, In: Biochemical Journal. 303, 3, p. 923-928 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

1993

[11] Tissue Factor Pathway Inhibitor

Girard, T. J. & Broze, G. J., Jan 1 1993, In: Methods in enzymology. 222, C, p. 195-209 15 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

1992

The interaction between LACI and heparin

Broze, G. J., Wesselschmidt, R., Higuchi, D., Girard, T., Likert, K., MacPhail, L. & Wun, T. C., Jan 1 1992, In: Advances in Experimental Medicine and Biology. 313, p. 189-197 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Tissue factor pathway inhibitor: The carboxy-terminus is required for optimal inhibition of factor Xa

Wesselschmidt, R., Likert, K., Girard, T., Wun, T. C. & Broze, G. J., Apr 15 1992, In: Blood. 79, 8, p. 2004-2010 7 p.

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

1991

Structure of the human lipoprotein-associated coagulation inhibitor gene: Intro/exon gene organization and localization of the gene to chromosome 2

Girard, T. J., Eddy, R., Wesselschmidt, R. L., MacPhail, L. A., Likert, K. M., Byers, M. G., Shows, T. B. & Broze, G. J., Mar 15 1991, In: Journal of Biological Chemistry. 266, 8, p. 5036-5041 6 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

1990

Endogenous phosphorylation of the lipoprotein-associated coagulation inhibitor at serine-2.

Girard, T. J., McCourt, D., Novotny, W. F., MacPhail, L. A., Likert, K. M. & Broze, G. J., Sep 15 1990, In: The Biochemical journal. 270, 3, p. 621-625 5 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Inhibition of factor VIIa-tissue factor coagulation activity by a hybrid protein

Girard, T. J., Macphail, L. A., Likert, K. M., Novotny, W. F., Miletich, J. P. & Broze, G. J., 1990, In: Science. 248, 4961, p. 1421-1424 4 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Regulation of Coagulation by a Multivalent Kunitz-Type Inhibitor

Broze, G. J., Girard, T. J. & Novotny, W. F., Aug 1 1990, In: Biochemistry. 29, 33, p. 7539-7546 8 p.

Research output: Contribution to journal › Article › peer-review

342 Scopus citations

1989

Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor

Girard, T. J., Warren, L. A., Novotny, W. F., Likert, K. M., Brown, S. G., Miletich, J. P. & Broze, G. J., 1989, In: Nature. 338, 6215, p. 518-520 3 p.

Research output: Contribution to journal › Article › peer-review

461 Scopus citations

Identification of the 1.4 KB and 4.0 KB messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein

Girard, T. J., Warren, L. A., Novotny, W. F., Bejcek, B. E., Miletich, J. P. & Broze, G. J., Jul 1 1989, In: Thrombosis Research. 55, 1, p. 37-50 14 p.

Research output: Contribution to journal › Article › peer-review