Thomas Brett

Assocaite Professor of Medicine, Associate Professor of Biochemistry and Molecular Biophysics, Associate Professor of Cell Biology and Physiology

1793 Citations

Research output per year

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Personal profile

Research interests

Dr. Brett’s group applies structural, biophysical, and functional studies to elucidate the molecular mechanisms that underlie chronic inflammatory diseases such as asthma, COPD, and Alzheimer’s disease.

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Research Output

1793 Citations
37 Article
7 Review article

Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement

Berry, K. N. & Brett, T. J., Jan 28 2020, In : Cell Reports. 30, 4, p. 1141-1151.e3

Research output: Contribution to journal › Article

Open Access

2 Scopus citations

The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer

Chanthamontri, C. K., Jordan, D. S., Wang, W., Wu, C., Lin, Y., Brett, T. J., Gross, M. L. & Leung, D. W., Feb 12 2019, In : Biochemistry. 58, 6, p. 657-664 8 p.

Research output: Contribution to journal › Article

4 Scopus citations

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., Bradley, J., Budde, J., Ibanez, L., Fernandez, M. V., Blennow, K., Zetterberg, H., Heslegrave, A., Johansson, P. M., Svensson, J., Nellgård, B. & 16 others, Lleo, A., Alcolea, D., Clarimon, J., Rami, L., Molinuevo, J. L., Suárez-Calvet, M., Morenas-Rodríguez, E., Kleinberger, G., Ewers, M., Harari, O., Haass, C., Brett, T. J., Benitez, B. A., Karch, C. M., Piccio, L. & Cruchaga, C., Aug 14 2019, In : Science translational medicine. 11, 505, eaau2291.

Research output: Contribution to journal › Article

22 Scopus citations

Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps

Berry, K. N., Kober, D. L., Su, A. & Brett, T. J., Oct 2018, In : BioEssays. 40, 10, 1800086.

Research output: Contribution to journal › Review article

2 Scopus citations

YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria

Ohlemacher, S. I., Xu, Y., Kober, D. L., Malik, M., Nix, J. C., Brett, T. J. & Henderson, J. P., Dec 21 2018, In : Journal of Biological Chemistry. 293, 51, p. 19572-19585 14 p.

Research output: Contribution to journal › Article

1 Scopus citations