Research output per year
Research output per year
Personal profile
Research interests
Dr. Brett’s group applies structural, biophysical, and functional studies to elucidate the molecular mechanisms that underlie chronic inflammatory diseases such as asthma, COPD, and Alzheimer’s disease.
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Dive into the research topics where Thomas Brett is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Research output
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Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42
Kober, D. L., Stuchell-Brereton, M. D., Kluender, C. E., Dean, H. B., Strickland, M. R., Steinberg, D. F., Nelson, S. S., Baban, B., Holtzman, D. M., Frieden, C., Alexander-Brett, J., Roberson, E. D., Song, Y. & Brett, T. J., 2020, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review
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Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement
Berry, K. N. & Brett, T. J., Jan 28 2020, In: Cell Reports. 30, 4, p. 1141-1151.e3Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer
Chanthamontri, C. K., Jordan, D. S., Wang, W., Wu, C., Lin, Y., Brett, T. J., Gross, M. L. & Leung, D. W., Feb 12 2019, In: Biochemistry. 58, 6, p. 657-664 8 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., Bradley, J., Budde, J., Ibanez, L., Fernandez, M. V., Blennow, K., Zetterberg, H., Heslegrave, A., Johansson, P. M., Svensson, J., Nellgård, B. & 16 others, , Aug 14 2019, In: Science translational medicine. 11, 505, eaau2291.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps
Berry, K. N., Kober, D. L., Su, A. & Brett, T. J., Oct 2018, In: BioEssays. 40, 10, 1800086.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations