Personal profile

Research interests

Research in the Che lab will be aimed at comprehensively characterizing and dissecting the molecular mechanisms of opioid receptor signaling. The goal is to gain an atomic-level understanding of opioid receptor activation, and to use this information to develop chemical and synthetic biologic tools (e.g., nanobodies) to ultimately lead to the development of safer, non-addictive pain medications. His work will integrate structural (e.g., X-ray, Cryo-EM) and pharmacological approaches, and leverage these data to generate subtype-specific novel chemicals as in vivo precision pharmacology probes to understand opioid receptor signaling spatiotemporally. These will be useful probes to interrogate signaling pathways and provide a platform for the discovery of new chemical and biological matter for potential therapeutic applications.

Available to Mentor:

  • PhD/MSTP Students

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Collaborations and top research areas from the last five years

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