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Research interests

Research in the Che lab will be aimed at comprehensively characterizing and dissecting the molecular mechanisms of opioid receptor signaling. The goal is to gain an atomic-level understanding of opioid receptor activation, and to use this information to develop chemical and synthetic biologic tools (e.g., nanobodies) to ultimately lead to the development of safer, non-addictive pain medications. His work will integrate structural (e.g., X-ray, Cryo-EM) and pharmacological approaches, and leverage these data to generate subtype-specific novel chemicals as in vivo precision pharmacology probes to understand opioid receptor signaling spatiotemporally. These will be useful probes to interrogate signaling pathways and provide a platform for the discovery of new chemical and biological matter for potential therapeutic applications.

Available to Mentor:

  • PhD/MSTP Students


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  • Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells

    Cai, B., El Daibani, A., Bai, Y., Che, T. & Krusemark, C. J., Apr 24 2023, In: JACS Au. 3, 4, p. 1076-1088 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Insights into distinct signaling profiles of the µOR activated by diverse agonists

    Qu, Q., Huang, W., Aydin, D., Paggi, J. M., Seven, A. B., Wang, H., Chakraborty, S., Che, T., DiBerto, J. F., Robertson, M. J., Inoue, A., Suomivuori, C. M., Roth, B. L., Majumdar, S., Dror, R. O., Kobilka, B. K. & Skiniotis, G., Apr 2023, In: Nature Chemical Biology. 19, 4, p. 423-430 8 p.

    Research output: Contribution to journalArticlepeer-review

    7 Scopus citations
  • Ligand and G-protein selectivity in the κ-opioid receptor

    Han, J., Zhang, J., Nazarova, A. L., Bernhard, S. M., Krumm, B. E., Zhao, L., Lam, J. H., Rangari, V. A., Majumdar, S., Nichols, D. E., Katritch, V., Yuan, P., Fay, J. F. & Che, T., May 11 2023, In: Nature. 617, 7960, p. 417-425 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Structure-based design of bitopic ligands for the µ-opioid receptor

    Faouzi, A., Wang, H., Zaidi, S. A., DiBerto, J. F., Che, T., Qu, Q., Robertson, M. J., Madasu, M. K., El Daibani, A., Varga, B. R., Zhang, T., Ruiz, C., Liu, S., Xu, J., Appourchaux, K., Slocum, S. T., Eans, S. O., Cameron, M. D., Al-Hasani, R., Pan, Y. X., & 6 othersRoth, B. L., McLaughlin, J. P., Skiniotis, G., Katritch, V., Kobilka, B. K. & Majumdar, S., Jan 26 2023, In: Nature. 613, 7945, p. 767-774 8 p.

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations
  • Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

    Kaplan, A. L., Confair, D. N., Kim, K., Barros-Álvarez, X., Rodriguiz, R. M., Yang, Y., Kweon, O. S., Che, T., McCorvy, J. D., Kamber, D. N., Phelan, J. P., Martins, L. C., Pogorelov, V. M., DiBerto, J. F., Slocum, S. T., Huang, X. P., Kumar, J. M., Robertson, M. J., Panova, O., Seven, A. B., & 7 othersWetsel, A. Q., Wetsel, W. C., Irwin, J. J., Skiniotis, G., Shoichet, B. K., Roth, B. L. & Ellman, J. A., Oct 20 2022, In: Nature. 610, 7932, p. 582-591 10 p.

    Research output: Contribution to journalArticlepeer-review

    19 Scopus citations