Tamara Doering

Professor of Molecular Microbiology, Alumni Endowed Professor of Molecular Microbiology

    • 4534 Citations
    1985 …2020

    Research output per year

    If you made any changes in Pure these will be visible here soon.

    Personal profile

    Research interests

    Cryptococcus neoformans is a pathogenic fungus responsible for serious opportunistic infections in immunocompromised individuals. My lab studies unique aspects of cryptococcal biology that are of biological interest and may suggest targets for badly needed antifungal chemotherapy. The main virulence factor of C. neoformans is its extensive polysaccharide capsule, a unique protective structure that is required for virulence. We are taking several approaches to understanding capsule biosynthesis, and to investigating interactions of this pathogen with host cells. In our studies we apply approaches and methodology drawn from biochemistry, genetics, and molecular and cell biology. We take advantage of sequence information, high throughput technology (microarray and robotics), sophisticated imaging, animal models, and methods we have developed for RNA interference in this organism. These approaches allow us to address the molecular mechanisms of capsule synthesis and cryptococcal pathogenesis.

    Fingerprint Dive into the research topics where Tamara Doering is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 8 Similar Profiles

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    • 4534 Citations
    • 74 Article
    • 9 Review article
    • 3 Short survey
    • 2 Chapter

    5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

    Billmyre, R. B., Applen Clancey, S., Li, L. X., Doering, T. L. & Heitman, J., Dec 1 2020, In : Nature communications. 11, 1, 127.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations

    Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport

    Li, L. X., Hole, C. R., Rangel-Moreno, J., Abdul Khader, S. & Doering, T. L., Jul 21 2020, In : Infection and immunity. 88, 8

    Research output: Contribution to journalArticle

  • An Automated Assay to Measure Phagocytosis of Cryptococcus neoformans

    Chang, A. L., Hole, C. R. & Doering, T. L., Jun 2019, In : Current Protocols in Microbiology. 53, 1, e79.

    Research output: Contribution to journalArticle

  • 1 Scopus citations
  • Cdk8 and ssn801 regulate oxidative stress resistance and virulence in cryptococcus neoformans

    Chang, A. L., Kang, Y. & Doering, T. L., Jan 1 2019, In : mBio. 10, 1, e02818-18.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations