Susan Dutcher

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Susan Dutcher

Professor of Genetics, Professor of Cell Biology and Physiology

 https://orcid.org/0000-0001-5689-5753

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    PhD/MSTP Students

    • 12683
      Citations
    1981 …2024

    Research activity per year

    Personal profile

    Research interests

    In the last few years, knowledge about the role of cilia in human biology has grown exponentially. Defects in cilia are connected to developmental defects as well as adult disorders including obesity and diabetes. Using the alga, Chlamydomonas, we have studied the maturation of basal bodies, the gating of proteins into the cilium, genetic interactions of intraflagellar transport proteins, ciliary motility, and signaling through the ciliary membrane proteins using genetics, cell biology and comparative genomics. These studies have lead to better understanding of the role of cilia in polycystic kidney disease and primary ciliary dyskinesia. Recently, we have examined the role of cilia genes in cancer.

    Available to Mentor:

    • PhD/MSTP Students

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    • A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

      Trans-Omics for Precision Medicine (TOPMed) program, The INVENT Consortium, de Vries, P. S., Reventun, P., Brown, M. R., Heath, A. S., Huffman, J. E., Le, N. Q., Bebo, A., Brody, J. A., Temprano-Sagrera, G., Raffield, L. M., Ozel, A. B., Thibord, F., Jain, D., Lewis, J. P., Rodriguez, B. A. T., Pankratz, N., Taylor, K. D. & Polasek, O. & 182 others, Chen, M. H., Yanek, L. R., Carrasquilla, G. D., Marioni, R. E., Kleber, M. E., Trégouët, D. A., Yao, J., Li-Gao, R., Joshi, P. K., Trompet, S., Martinez-Perez, A., Ghanbari, M., Howard, T. E., Reiner, A. P., Arvanitis, M., Ryan, K. A., Bartz, T. M., Rudan, I., Faraday, N., Linneberg, A., Ekunwe, L., Davies, G., Delgado, G. E., Suchon, P., Guo, X., Rosendaal, F. R., Klaric, L., Noordam, R., van Rooij, F., Curran, J. E., Wheeler, M. M., Osburn, W. O., O'Connell, J. R., Boerwinkle, E., Beswick, A., Psaty, B. M., Kolcic, I., Souto, J. C., Becker, L. C., Hansen, T., Doyle, M. F., Harris, S. E., Moissl, A. P., Deleuze, J. F., Rich, S. S., van Hylckama Vlieg, A., Campbell, H., Stott, D. J., Soria, J. M., de Maat, M. P. M., Almasy, L., Brody, L. C., Auer, P. L., Abe, N., Abecasis, G., Aguet, F., Albert, C., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Ardlie, K., Arking, D., Arnett, D. K., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Ayas, N., Balasubramanian, A., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Barwick, L., Beaty, T., Beck, G., Becker, D., Becker, L., Beer, R., Beitelshees, A., Benjamin, E., Benos, T., Bezerra, M., Bielak, L., Bis, J., Blackwell, T., Blangero, J., Blue, N., Bowden, D. W., Bowler, R., Brody, J., Broeckel, U., Broome, J., Brown, D., Bunting, K., Burchard, E., Bustamante, C., Buth, E., Cade, B., Cardwell, J., Carey, V., Carrier, J., Carson, A. P., Carty, C., Casaburi, R., Casas Romero, J. P., Casella, J., Castaldi, P., Chaffin, M., Chang, C., Chang, Y. C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Ida Chen, Y. D., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Chung, R. H., Clish, C., Comhair, S., Conomos, M., Cornell, E., Correa, A., Crandall, C., Crapo, J., Cupples, L. A., Curran, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., David, S., Davis, C., Daya, M., de Andrade, M., de las Fuentes, L., de Vries, P., DeBaun, M., Deka, R., DeMeo, D., Devine, S., Dinh, H., Doddapaneni, H., Duan, Q., Dugan-Perez, S., Duggirala, R., Durda, J. P., Dutcher, S. K., Eaton, C., El Boueiz, A., Ellinor, P., Emery, L., Erzurum, S., Farber, C., Farek, J., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Frazar, C., Fu, M., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, S., Gao, Y., Gass, M., Geiger, H., Gelb, B., Geraci, M., Germer, S., Gerszten, R., Gu, C. C., Rao, D. C. & Sung, Y. J., May 2 2024, In: Blood. 143, 18, p. 1845-1855 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2 Scopus citations

    • Assembly of FAP93 at the proximal axoneme in Chlamydomonas cilia

      Hwang, J., Yanagisawa, H., Davis, K. C., Hunter, E. L., Fox, L. A., Jimenez, A. R., Goodwin, R. E., Gordon, S. A., Stuart, C. D. E., Bower, R., Porter, M. E., Dutcher, S. K., Sale, W. S., Lechtreck, K. F. & Alford, L. M., Nov 2024, In: Cytoskeleton. 81, 11, p. 539-555 17 p.

      Research output: Contribution to journal › Article › peer-review

      1 Scopus citations

    • Gene dosage of independent dynein arm motor preassembly factors influences cilia assembly in Chlamydomonas reinhardtii

      Penny, G. M. & Dutcher, S. K., Mar 18 2024, In: PLoS genetics. 20, 3, 1011038.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices

      Dai, J., Ma, M., Niu, Q., Eisert, R. J., Wang, X., Das, P., Lechtreck, K. F., Dutcher, S. K., Zhang, R. & Brown, A., Apr 11 2024, In: Cell. 187, 8, p. 1907-1921.e16

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1 Scopus citations

    • Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular structures

      Langner, E., Puapatanakul, P., Pudlowski, R., Alsabbagh, D. Y., Miner, J. H., Horani, A., Dutcher, S. K., Brody, S. L., Wang, J. T., Suleiman, H. Y. & Mahjoub, M. R., Nov 2024, In: Cytoskeleton. 81, 11, p. 618-638 21 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
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