Research output per year
Research output per year
Personal profile
Research interests
My research interest has been focused on understanding the molecular basis of ion channel function, and in particular on membrane lipid-channel interactions. In order to tackle this difficult problem, I have combined computational modeling, in vitro functional assays of purified proteins reconstituted in synthetic membranes, as well as structure determination through x-ray crystallography and single particle cryo-EM. This multidisciplinary approach will generate a holistic picture of channel functions and bring novel insights for specific regulation of a target ion channel of interest.
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Collaborations and top research areas from the last five years
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A new Kir channel player in Parkinson's disease
Lee, S. J., Jun 15 2025, In: Journal of Physiology. 603, 12, p. 3485-3486 2 p.Research output: Contribution to journal › Article › peer-review
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Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels
Lee, S. J., Gao, J., Thompson, E., Mount, J. & Nichols, C. G., Apr 2025, In: Journal of Biological Chemistry. 301, 4, 108393.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
From Selective Permeation to Physiology in Potassium Channels
Lee, S. J., Schillings, J., De Vries, R., Matamoros, M., De Groot, B. L. & Nichols, C. G., 2025, In: Function. 6, 6, zqaf050.Research output: Contribution to journal › Review article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating
Zangerl-Plessl, E. M., Stary-Weinzinger, A., Nichols, C. G. & Lee, S. J., Nov 3 2025, In: The Journal of general physiology. 157, 6Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels
Lee, S. J., Maeda, S., Gao, J. & Nichols, C. G., 2023, In: Function. 4, 3, zqad016.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations