Steven Paul

2024

Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity

Pyun, J. M., Park, Y. H., Youn, Y. C., Kang, M. J., Shim, K. H., Jang, J. W., You, J., Nho, K., Kim, S. Y., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J. & Morris, J. & 63 others, Shaw, L. M., Sorensen, G., Carrillo, M., Kuller, L., Raichle, M., Paul, S., Davies, P., Fillit, H., Hefti, F., Holtzman, D., Mesulam, M. M., Potter, W., Snyder, P., Hendrix, J., Vasanthakumar, A., Montine, T., Rafii, M., Chow, T., Raman, R., Jimenez, G., Donohue, M., Gessert, D., Harless, K., Salazar, J., Cabrera, Y., Walter, S., Hergesheimer, L., Harvey, D., Donohue, M., Bernstein, M., Fox, N., Thompson, P., Schuff, N., DeCArli, C., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Landau, S., Cairns, N. J., Franklin, E., Lee, V., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Faber, K., Kim, S., Albert, M., Frank, R., Hsiao, J. & Khachaturian, Z., Dec 2024, In: Translational psychiatry. 14, 1, 88.

Research output: Contribution to journal › Article › peer-review

Open Access

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Toral-Rios, D., Long, J. M., Ulrich, J. D., Yu, J., Strickland, M. R., Han, X., Holtzman, D. M., Cashikar, A. G. & Paul, S. M., Apr 1 2024, In: Journal of Experimental Medicine. 221, 4, e20232000.

Research output: Contribution to journal › Article › peer-review

Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme Cyp46a1 on Behavior and Hippocampal Transcription in Mouse

Shu, H. J., Ziolkowski, L. H., Salvatore, S. V., Benz, A. M., Wozniak, D., Yuede, C. M., Paul, S., Zorumski, C. F. & Mennerick, S., Mar 2024, In: Biomolecules. 14, 3, 254.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Efficacy and safety of the muscarinic receptor agonist KarXT (xanomeline–trospium) in schizophrenia (EMERGENT-2) in the USA: results from a randomised, double-blind, placebo-controlled, flexible-dose phase 3 trial

Kaul, I., Sawchak, S., Correll, C. U., Kakar, R., Breier, A., Zhu, H., Miller, A. C., Paul, S. M. & Brannan, S. K., Jan 13 2024, In: The Lancet. 403, 10422, p. 160-170 11 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia A Randomized Clinical Trial

Kaul, I., Sawchak, S., Walling, D. P., Tamminga, C. A., Breier, A., Zhu, H., Miller, A. C., Paul, S. M. & Brannan, S. K., Aug 7 2024, In: JAMA psychiatry. 81, 8, p. 749-756 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Finding new and better treatments for psychiatric disorders

Paul, S. M. & Potter, W. Z., Jan 2024, In: Neuropsychopharmacology. 49, 1, p. 3-9 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning

Izumi, Y., O'Dell, K. A., Cashikar, A. G., Paul, S., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Jun 2024, In: PloS one. 19, 6 June, e0304481.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Evidence of trospium’s ability to mitigate cholinergic adverse events related to xanomeline: phase 1 study results

Breier, A., Brannan, S. K., Paul, S. M. & Miller, A. C., May 2023, In: Psychopharmacology. 240, 5, p. 1191-1198 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol

Cashikar, A. G., Toral-Rios, D., Timm, D., Romero, J., Strickland, M., Long, J. M., Han, X., Holtzman, D. M. & Paul, S. M., Apr 2023, In: Journal of lipid research. 64, 4, 100350.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Structural basis of efficacy-driven ligand selectivity at GPCRs

Powers, A. S., Pham, V., Burger, W. A. C., Thompson, G., Laloudakis, Y., Barnes, N. W., Sexton, P. M., Paul, S. M., Christopoulos, A., Thal, D. M., Felder, C. C., Valant, C. & Dror, R. O., Jul 2023, In: Nature Chemical Biology. 19, 7, p. 805-814 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M₄ mAChR

Burger, W. A. C., Pham, V., Vuckovic, Z., Powers, A. S., Mobbs, J. I., Laloudakis, Y., Glukhova, A., Wootten, D., Tobin, A. B., Sexton, P. M., Paul, S. M., Felder, C. C., Danev, R., Dror, R. O., Christopoulos, A., Valant, C. & Thal, D. M., Dec 2023, In: Nature communications. 14, 1, 5440.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2022

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative, Jul 2022, In: Nature Aging. 2, 7, p. 616-634 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Antipsychotic Efficacy of KarXT (Xanomeline-Trospium): Post Hoc Analysis of Positive and Negative Syndrome Scale Categorical Response Rates, Time Course of Response, and Symptom Domains of Response in a Phase 2 Study

Weiden, P. J., Breier, A., Kavanagh, S., Miller, A. C., Brannan, S. K. & Paul, S. M., May 2022, In: Journal of Clinical Psychiatry. 83, 3

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Biased Profile of Xanomeline at the Recombinant Human M₄Muscarinic Acetylcholine Receptor

McDonald, J. K., Van Der Westhuizen, E. T., Pham, V., Thompson, G., Felder, C. C., Paul, S. M., Thal, D. M., Christopoulos, A. & Valant, C., Apr 20 2022, In: ACS Chemical Neuroscience. 13, 8, p. 1206-1218 13 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Effectiveness of KarXT (xanomeline-trospium) for cognitive impairment in schizophrenia: post hoc analyses from a randomised, double-blind, placebo-controlled phase 2 study

Sauder, C., Allen, L. A., Baker, E., Miller, A. C., Paul, S. M. & Brannan, S. K., Dec 2022, In: Translational psychiatry. 12, 1, 491.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment

for the Alzheimer's Disease Neuroimaging Initiative, Aug 2022, In: GeroScience. 44, 4, p. 2319-2336 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

The trend of disruption in the functional brain network topology of Alzheimer’s disease

for the Alzheimer's Disease Neuroimaging Initiative, Dec 2022, In: Scientific reports. 12, 1, 14998.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2021

A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol

Izumi, Y., Cashikar, A. G., Krishnan, K., Paul, S. M., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Dec 8 2021, In: Journal of Neuroscience. 41, 49, p. 10054-10064 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Association of Initial β-Amyloid Levels with Subsequent Flortaucipir Positron Emission Tomography Changes in Persons without Cognitive Impairment

Alzheimer’s Disease Neuroimaging Initiative, Feb 2021, In: JAMA Neurology. 78, 2, p. 217-228 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia

Brannan, S. K., Sawchak, S., Miller, A. C., Lieberman, J. A., Paul, S. M. & Breier, A., Feb 25 2021, In: New England Journal of Medicine. 384, 8, p. 717-726 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

166 Scopus citations

2020

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., Petsko, G. A., Holtzman, D. M., Paul, S. M., Paul, S. M. & Luo, W., Jun 17 2020, In: Journal of Neuroinflammation. 17, 1, 192.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective

Paul, S. M., Pinna, G. & Guidotti, A., May 2020, In: Neurobiology of Stress. 12, 100215.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis

Mannara, F., Radosevic, M., Planagumà, J., Soto, D., Aguilar, E., García-Serra, A., Maudes, E., Pedreño, M., Paul, S., Doherty, J., Quirk, M., Dai, J., Gasull, X., Lewis, M. & Dalmau, J., Sep 1 2020, In: Brain. 143, 9, p. 2709-2720 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease

AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative, Dec 2020, In: Neurology: Genetics. 6, 6, e517.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In: Scientific reports. 10, 1, 12063.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In: Scientific reports. 10, 1, 2975.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

The Alzheimer Disease Neuroimaging Initiative, Dec 1 2020, In: Nature communications. 11, 1, 411.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

TPA deficiency underlies neurovascular coupling dysfunction by amyloid-b

Park, L., Zhou, J., Koizumi, K., Wang, G., Anfray, A., Ahn, S. J., Seo, J., Zhou, P., Zhao, L., Paul, S., Anrather, J. & Iadecola, C., Oct 14 2020, In: Journal of Neuroscience. 40, 42, p. 8160-8173 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

2019

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In: Scientific reports. 9, 1, 19589.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In: Scientific reports. 9, 1, 13845.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Zorumski, C. F., Paul, S. M., Covey, D. F. & Mennerick, S., Nov 2019, In: Neurobiology of Stress. 11, 100196.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In: Nature communications. 10, 1, 3310.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

for Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In: Scientific reports. 9, 1, 1952.

Research output: Contribution to journal › Article › peer-review

Open Access

284 Scopus citations

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

For the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In: Scientific reports. 9, 1, 2235.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Targeting apolipoprotein E for treating Alzheimer's disease

Bales, K. R. & Paul, S. M., Sep 14 2019, In: Neuroscience Letters. 709, 134366.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In: Nature communications. 10, 1, 1766.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Trial of SAGE-217 in patients with major depressive disorder

Gunduz-Bruce, H., Silber, C., Kaul, I., Rothschild, A. J., Riesenberg, R., Sankoh, A. J., Li, H., Lasser, R., Zorumski, C. F., Rubinow, D. R., Paul, S. M., Jonas, J., Doherty, J. J. & Kanes, S. J., Sep 5 2019, In: New England Journal of Medicine. 381, 10, p. 903-911 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

163 Scopus citations

2018

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Rosenberg, J. B., Kaplitt, M. G., De, B. P., Chen, A., Flagiello, T., Salami, C., Pey, E., Zhao, L., Ricart Arbona, R. J., Monette, S., Dyke, J. P., Ballon, D. J., Kaminsky, S. M., Sondhi, D., Petsko, G. A., Paul, S. M. & Crystal, R. G., Mar 2018, In: Human Gene Therapy Clinical Development. 29, 1, p. 24-47 24 p.

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

Koizumi, K., Hattori, Y., Ahn, S. J., Buendia, I., Ciacciarelli, A., Uekawa, K., Wang, G., Hiller, A., Zhao, L., Voss, H. U., Paul, S. M., Schaffer, C., Park, L. & Iadecola, C., Dec 1 2018, In: Nature communications. 9, 1, 3816.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis

Warikoo, N., Brunwasser, S. J., Benz, A., Shu, H. J., Paul, S. M., Lewis, M., Doherty, J., Quirk, M., Piccio, L., Zorumski, C. F., Day, G. S. & Mennerick, S., Mar 28 2018, In: Journal of Neuroscience. 38, 13, p. 3218-3229 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

The Genetic FTD Initiative (GENFI) & The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2018, In: Nature communications. 9, 1, 4273.

Research output: Contribution to journal › Article › peer-review

Open Access

283 Scopus citations

2017

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Alzheimer’s Disease Neuroimaging Initiative, Sep 28 2017, In: Nature. 549, 7673, p. 523-527 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

778 Scopus citations

Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease

Alzheimer's Disease Neuroimaging Initiative, May 2017, In: JAMA Neurology. 74, 5, p. 557-566 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

662 Scopus citations

Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial

Kanes, S., Colquhoun, H., Gunduz-Bruce, H., Raines, S., Arnold, R., Schacterle, A., Doherty, J., Epperson, C. N., Deligiannidis, K. M., Riesenberg, R., Hoffmann, E., Rubinow, D., Jonas, J., Paul, S. & Meltzer-Brody, S., Jul 29 2017, In: The Lancet. 390, 10093, p. 480-489 10 p.

Research output: Contribution to journal › Article › peer-review

317 Scopus citations

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Du, L., Liu, K., Yao, X., Yan, J., Risacher, S. L., Han, J., Guo, L., Saykin, A. J., Shen, L., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Morris, J. & Shaw, L. M. & 293 others, Khachaturian, Z., Sorensen, G., Carrillo, M., Kuller, L., Raichle, M., Paul, S., Davies, P., Fillit, H., Hefti, F., Holtzman, D., Mesulam, M. M., Potter, W., Snyder, P., Schwartz, A., Montine, T., Thomas, R. G., Donohue, M., Walter, S., Gessert, D., Sather, T., Jiminez, G., Balasubramanian, A. B., Mason, J., Sim, I., Harvey, D., Bernstein, M., Fox, N., Thompson, P., Schuff, N., Decarli, C., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Landau, S., Cairns, N. J., Franklin, E., Taylor-Reinwald, L., Lee, V., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Faber, K., Kim, S., Nho, K., Thal, L., Buckholtz, N., Albert, M., Frank, R., Hsiao, J., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R., Dolen, S., Schneider, L. S., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B. M., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J. L., Lord, J. L., Mason, S. S., Albers, C. S., Knopman, D., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Pavlik, V., Shibley, V., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L. S., Bell, K. L., Ances, B., Carroll, M., Creech, M. L., Franklin, E., Mintun, M. A., Schneider, S., Oliver, A., Marson, D., Geldmacher, D., Love, M. N., Griffith, R., Clark, D., Brockington, J., Roberson, E., Grossman, H., Mitsis, E., Shah, R. C., Detoledo-Morrell, L., Duara, R., Greig-Custo, M. T., Barker, W., Onyike, C., D'Agostino, D., Kielb, S., Sadowski, M., Sheikh, M. O., Ulysse, A., Gaikwad, M., Murali Doraiswamy, P., Petrella, J. R., Borges-Neto, S., Wong, T. Z., Coleman, E., Arnold, S. E., Karlawish, J. H., Wolk, D. A., Clark, C. M., Smith, C. D., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Lopez, O. L., Oakley, M. A., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Preda, A., Nguyen, D., Womack, K., Mathews, D., Quiceno, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Swerdlow, R. H., Brooks, W. M., Apostolova, L., Tingus, K., Woo, E., Silverman, D. H. S., Lu, P. H., Bartzokis, G., Graff-Radford, N. R., Parfitt, F., Poki-Walker, K., Farlow, M. R., Marie Hake, A., Matthews, B. R., Brosch, J. R., Herring, S., Van Dyck, C. H., Carson, R. E., MacAvoy, M. G., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Mudge, B., Sossi, V., Feldman, H., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Rogers, J., Trost, D., Kertesz, A., Bernick, C., Munic, D., Rogalski, E., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Scott Turner, R., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M. N., Belden, C. M., Jacobson, S. A., Sirrel, S. A., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Lynn Johnson, P., Obisesan, T. O., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Decarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C. M., Tariot, P., Burke, A., Milliken, A. M., Trncic, N., Fleisher, A., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Kelly, B., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Flashman, L. A., Seltzer, M., Hynes, M. L., Santulli, R. B., Sink, K. M., Gordineer, L., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Tremont, G., Daiello, L. A., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Ekstam Smith, K., Koleva, H., Nam, K. W., Shim, H., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Ashok Raj, B. & Fargher, K., Dec 1 2017, In: Scientific reports. 7, 1, 14052.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2016

Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults

Alzheimer's Disease Neuroimaging Initiative, Jun 2016, In: JAMA Neurology. 73, 6, p. 721-732 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

245 Scopus citations

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

the Alzheimer's Disease Neuroimaging Initiative, Jun 21 2016, In: Nature communications. 7, 11934.

Research output: Contribution to journal › Article › peer-review

Open Access

770 Scopus citations

Hypertension enhances A β -induced neurovascular dysfunction, promotes β -secretase activity, and leads to amyloidogenic processing of APP

Faraco, G., Park, L., Zhou, P., Luo, W., Paul, S. M., Anrather, J. & Iadecola, C., Jan 1 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 1, p. 241-252 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

129 Scopus citations

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models

Zhao, L., Gottesdiener, A. J., Parmar, M., Li, M., Kaminsky, S. M., Chiuchiolo, M. J., Sondhi, D., Sullivan, P. M., Holtzman, D. M., Crystal, R. G. & Paul, S. M., Aug 1 2016, In: Neurobiology of Aging. 44, p. 159-172 14 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D. & Grutzendler, J., May 18 2016, In: Neuron. 90, 4, p. 724-739 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

439 Scopus citations

Steven Paul

Research output

Search results