Steven Paul

2002

Aβ immunization and anti-Aβ antibodies: Potential therapies for the prevention and treatment of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Paul, S. M. & DeMattos, R. B., Dec 7 2002, In: Advanced Drug Delivery Reviews. 54, 12, p. 1603-1613 11 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Brain to plasma amyloid-β efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M. & Holtzman, D. M., Mar 22 2002, In: Science. 295, 5563, p. 2264-2267 4 p.

Research output: Contribution to journal › Article › peer-review

543 Scopus citations

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

DeMattos, R. B., O'dell, M. A., Parsadanian, M., Taylor, J. W., Harmony, J. A. K., Bales, K. R., Paul, S. M., Aronow, B. J. & Holtzman, D. M., Aug 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 16, p. 10843-10848 6 p.

Research output: Contribution to journal › Article › peer-review

292 Scopus citations

Developing novel treatments for mood disorders: Accelerating discovery

Tamminga, C. A., Nemeroff, C. B., Blakely, R. D., Brady, L., Carter, C. S., Davis, K. L., Dingledine, R., Gorman, J. M., Grigoriadis, D. E., Henderson, D. C., Innis, R. B., Killen, J., Laughren, T. P., McDonald, W. M., Murphy, G. M., Paul, S. M., Rudorfer, M. V., Sausville, E., Schatzberg, A. F. & Scolnick, E. M. & 1 others, Suppes, T., Sep 15 2002, In: Biological Psychiatry. 52, 6, p. 589-609 21 p.

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Does my mouse have Alzheimer's disease?

Dodart, J. C., Mathis, C., Bales, K. R. & Paul, S. M., Aug 2002, In: Genes, Brain and Behavior. 1, 3, p. 142-155 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

124 Scopus citations

Human and murine apoE markedly alters Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's Disease

Fagan, A. M., Watson, M., Parsadanian, M., Bales, K. R., Paul, S. M. & Holtzman, D. M., 2002, In: Neurobiology of Disease. 9, 3, p. 305-318 14 p.

Research output: Contribution to journal › Article › peer-review

244 Scopus citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer℉s disease model

Dodart, J. C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M. & Paul, S. M., May 2002, In: Nature neuroscience. 5, 5, p. 452-457 6 p.

Research output: Contribution to journal › Article › peer-review

837 Scopus citations

Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury

Arvin, K. L., Han, B. H., Du, Y., Lin, S. Z., Paul, S. M. & Holtzman, D. M., 2002, In: Annals of neurology. 52, 1, p. 54-61 8 p.

Research output: Contribution to journal › Article › peer-review

285 Scopus citations

NF-κB mediates IL-1β-induced synthesis/release of α₂-macroglobulin in a human glial cell line

Gao, F., Bales, K. R., Dodel, R. C., Liu, J., Chen, X., Hample, H., Farlow, M. R., Paul, S. M. & Du, Y., Sep 30 2002, In: Molecular Brain Research. 105, 1-2, p. 108-114 7 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Plaque-associated disruption of CSF and plasma amyloid-β (Aβ) equilibrium in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Parsadanian, M., O'Dell, M. A., Foss, E. M., Paul, S. M. & Holtzman, D. M., 2002, In: Journal of Neurochemistry. 81, 2, p. 229-236 8 p.

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

2001

Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease

Naidu, A., Catalano, R., Bales, K., Wu, S., Paul, S. M. & Cordell, B., May 8 2001, In: NeuroReport. 12, 6, p. 1265-1270 6 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons

Lin, S., Zhang, Y., Dodel, R., Farlow, M. R., Paul, S. M. & Du, Y., Nov 23 2001, In: Neuroscience Letters. 315, 1-2, p. 61-64 4 p.

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., Luecke, S., Phebus, L. A., Bymaster, F. P. & Paul, S. M., Dec 4 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 25, p. 14669-14674 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

722 Scopus citations

Neuroinflammation-induced acceleration of amyloid deposition in the APP^V717F transgenic mouse

Qiao, X., Cummins, D. J. & Paul, S. M., 2001, In: European Journal of Neuroscience. 14, 3, p. 474-482 9 p.

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Neuronal DNA damage correlates with overexpression of interleukin-1β converting enzyme in APPV717F mice

Sheng, J. G., Mrak, R. E., Jones, R. A., Brewer, M. M., Zhou, X. Q., McGinness, J., Woodward, S., Bales, K., Paul, S. M., Cordell, B. & Griffin, W. S. T., 2001, In: Neurobiology of Aging. 22, 6, p. 895-902 8 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: Nuclear factor κB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E

Petegnief, V., Saura, J., De Gregorio-Rocasolano, N. & Paul, S. M., Apr 10 2001, In: Neuroscience. 104, 1, p. 223-234 12 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C., Paul, S. M. & Holtzman, D. M., Jul 17 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 15, p. 8850-8855 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1233 Scopus citations

Reduced levels of amyloid β-peptide antibody in Alzheimer disease

Du, Y., Dodel, R., Hampel, H., Buerger, K., Lin, S., Eastwood, B., Bales, K., Gao, F., Moeller, H. J., Oertel, W., Farlow, M. & Paul, S., Sep 11 2001, In: Neurology. 57, 5, p. 801-805 5 p.

Research output: Contribution to journal › Article › peer-review

223 Scopus citations

Statistical aspects of quantitative image analysis of β-amyloid in the APP^V717F transgenic mouse model of Alzheimer's disease

Fishman, C. E., Cummins, D. J., Bales, K. R., DeLong, C. A., Esterman, M. A., Hanson, J. C., White, S. L., Paul, S. M. & Jordan, W. H., Jul 30 2001, In: Journal of Neuroscience Methods. 108, 2, p. 145-152 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

α-1-Antichymotrypsin promotes β-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease

Nilsson, L. N. G., Bales, K. R., DiCarlo, G., Gordon, M. N., Morgan, D., Paul, S. M. & Potter, H., Mar 1 2001, In: Journal of Neuroscience. 21, 5, p. 1444-1451 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

132 Scopus citations

2000

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APP(V717F) transgenic mice

Irizarry, M. C., Cheung, B. S., Rebeck, G. W., Paul, S. M., Bales, K. R. & Hyman, B. T., 2000, In: Acta Neuropathologica. 100, 5, p. 451-458 8 p.

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model

Holtzman, D. M., Fagan, A. M., Mackey, B., Tenkova, T., Sartorius, L., Paul, S. M., Bales, K., Ashe, K. H., Irizarry, M. C. & Hyman, B. T., 2000, In: Annals of neurology. 47, 6, p. 739-747 9 p.

Research output: Contribution to journal › Article › peer-review

281 Scopus citations

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D. & Paul, S. M., Mar 14 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 6, p. 2892-2897 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

773 Scopus citations

Association of an interleukin 1α polymorphism with Alzheimer's disease

Du, Y., Dodel, R. C., Eastwood, B. J., Bales, K. R., Gao, F., Lohmüller, F., Müller, U., Kurz, A., Zimmer, R., Evans, R. M., Hake, A., Gasser, T., Oertel, W. H., Griffin, W. S. T., Paul, S. M. & Farlow, M. R., 2000, In: Neurology. 55, 4, p. 480-483 4 p.

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene

Dodart, J. C., Mathis, C., Bales, K. R., Paul, S. M. & Ungerer, A., Jan 1 2000, In: NeuroReport. 11, 3, p. 603-607 5 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Modulation of Aβ deposition in APP transgenic mice by an apolipoprotein E null background

Irizarry, M. C., Rebeck, G. W., Cheung, B., Bales, K., Paul, S. M., Holzman, D. & Hyman, B. T., 2000, In: Annals of the New York Academy of Sciences. 920, p. 171-178 8 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice

Dodart, J. C., Mathis, C., Saura, J., Bales, K. R., Paul, S. M. & Ungerer, A., Apr 2000, In: Neurobiology of Disease. 7, 2, p. 71-85 15 p.

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Neuroinflammation and Alzheimer's disease: Critical roles for cytokine/Aβ-induced glial activation, NF-κB, and apolipoprotein E

Bales, K. R., Du, Y., Holtzman, D., Cordell, B. & Paul, S. M., 2000, In: Neurobiology of Aging. 21, 3, p. 427-432 6 p.

Research output: Contribution to journal › Comment/debate

126 Scopus citations

Overexpression of the neuritotrophic cytokine S100β precedes the appearance of neuritic β-amyloid plaquesin APPV717F mice

Sheng, J. G., Mrak, R. E., Bales, K. R., Cordell, B., Paul, S. M., Jones, R. A., Woodward, S., Zhou, X. Q., McGinness, J. M. & Griffin, W. S. T., 2000, In: Journal of Neurochemistry. 74, 1, p. 295-301 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

α2 Macroglobulin and the risk of Alzheimer's disease

Dodel, R. C., Du, Y., Bales, K. R., Gao, F., Eastwood, B., Glazier, B., Zimmer, R., Cordell, B., Hake, A., Evans, R., Gallagher-Thompson, D., Thompson, L. W., Tinklenberg, J. R., Pfefferbaum, A., Sullivan, E. V., Yesavage, J., Altstiel, L., Gasser, T., Farlow, M. R. & Murphy, G. M. & 1 others, Paul, S. M., Jan 25 2000, In: Neurology. 54, 2, p. 438-442 5 p.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

1999

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., Delong, C. A., Piccardo, P., Petegnief, V., Ghetti, B. & Paul, S. M., Dec 21 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 26, p. 15233-15238 6 p.

Research output: Contribution to journal › Article › peer-review

432 Scopus citations

Behavioral disturbances in transgenic mice overexpressing the V717F β- amyloid precursor protein

Dodart, J. C., Meziane, H., Mathis, C., Ungerer, A., Bales, K. R. & Paul, S. M., Jan 1 1999, In: Behavioral Neuroscience. 113, 5, p. 982-990 9 p.

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death

Dodel, R. C., Du, Y., Bales, K. R., Ling, Z., Carvey, P. M. & Paul, S. M., Jan 22 1999, In: Molecular Brain Research. 64, 1, p. 141-148 8 p.

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

CNS drug discovery in the 21st century: From genomics to combinatorial chemistry and back

Paul, S., Jan 1 1999, In: British Journal of Psychiatry. 174, FEB. SUPPL. 37, p. 23-25 3 p.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F β-amyloid precursor protein

Dodart, J. C., Mathis, C., Bales, K. R., Paul, S. M. & Ungerer, A., Dec 17 1999, In: Neuroscience Letters. 277, 1, p. 49-52 4 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y. & Paul, S. M., Mar 1999, In: Journal of Clinical Investigation. 103, 6, p. R15-R21

Research output: Contribution to journal › Article › peer-review

Open Access

302 Scopus citations

Mapping quantitative trait loci for seizure response to a GABA(A) receptor inverse agonist in mice

Gershenfeld, H. K., Neumann, P. E., Li, X., St. Jean, P. L. & Paul, S. M., May 15 1999, In: Journal of Neuroscience. 19, 10, p. 3731-3738 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Raloxifene and estradiol benzoate both fully restore hippocampal choline acetyltransferase activity in ovariectomized rats

Wu, X., Glinn, M. A., Ostrowski, N. L., Su, Y., Ni, B., Cole, H. W., Bryant, H. U. & Paul, S. M., Nov 13 1999, In: Brain Research. 847, 1, p. 98-104 7 p.

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Rapid detection of a pentanucleotide deletion polymorphism in the human α₂-macroglobulin gene [1]

Dodel, R. C., Bales, K. R., Farlow, M. R., Gasser, T., Paul, S. M. & Du, Y., 1999, In: Clinical chemistry. 45, 2, p. 307 1 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

9 Scopus citations

Rat B₂ sequences are induced in the hippocampal CA1 region after transient global cerebral ischemia

Liu, X., Clemens, J. A., Yin, T., Stephenson, D. T., Johnstone, E. M., Du, Y., Panetta, J. A., Paul, S. M. & Little, S. P., Oct 1 1999, In: Journal of Biological Chemistry. 274, 40, p. 28674-28681 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Sodium salicylate and 17β-estradiol attenuate nuclear transcription factor NF-κB translocation in cultured rat astroglial cultures following exposure to amyloid Aβ_1-40 and lipopolysaccharides

Dodel, R. C., Du, Y., Bales, K. R., Gao, F. & Paul, S. M., 1999, In: Journal of Neurochemistry. 73, 4, p. 1453-1460 8 p.

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

1998

A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish

Ginns, E. I., St. Jean, P., Philibert, R. A., Galdzicka, M., Damschroder-Williams, P., Thiel, B., Long, R. T., Ingraham, L. J., Dalwaldi, H., Murray, M. A., Ehlert, M., Paul, S., Remortel, B. G., Patel, A. P., Anderson, M. C. H., Shaio, C., Lau, E., Dymarskaia, I., Martin, B. M. & Stubblefield, B. & 11 others, Falls, K. M., Carulli, J. P., Keith, T. P., Fann, C. S. J., Lacy, L. G., Allen, C. R., Hostetter, A. M., Elston, R. C., Schork, N. J., Egeland, J. A. & Paul, S. M., Dec 22 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 26, p. 15531-15536 6 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Effect of inhibition of ornithine decarboxylase activity in a model of acute hepatocellular necrosis

Yurdaydin, C., Swain, M. G., Mininberg, E. D., Vergalla, J., Kleiner, D., Paul, S. M. & Jones, E. A., 1998, In: European Journal of Gastroenterology and Hepatology. 10, 6, p. 503-507 5 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Inorganic P(i) increases neuronal survival in the acute early phase following excitotoxic/oxidative insults

Glinn, M., Ni, B., Irwin, R. P., Kelley, S. W., Lin, S. Z. & Paul, S. M., May 1998, In: Journal of Neurochemistry. 70, 5, p. 1850-1858 9 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

Meziane, H., Dodart, J. C., Mathis, C., Little, S., Clemens, J., Paul, S. M. & Ungerer, A., Oct 13 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12683-12688 6 p.

Research output: Contribution to journal › Article › peer-review

328 Scopus citations

Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4- phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons

Dodel, R. C., Du, Y., Bales, K. R., Ling, Z. D., Carvey, P. M. & Paul, S. M., Jun 8 1998, In: Neuroscience. 86, 3, p. 701-707 7 p.

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

The NF-κB/Rel family of proteins mediates A β-induced neurotoxicity and glial activation

Bales, K. R., Du, Y., Dodel, R. C., Yan, G. M., Hamilton-Byrd, E. & Paul, S. M., Jun 1 1998, In: Molecular Brain Research. 57, 1, p. 63-72 10 p.

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Towards a genetics of anxious temperament: From mice to men

Gershenfeld, H. K. & Paul, S. M., 1998, In: Acta Psychiatrica Scandinavica. 98, SUPPL.S393, p. 56-65 10 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons

Ni, B., Wu, X., Su, Y., Stephenson, D., Smalstig, E. B., Clemens, J. & Paul, S. M., Mar 1998, In: Journal of Cerebral Blood Flow and Metabolism. 18, 3, p. 248-256 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

150 Scopus citations

Transient increase in cerebellar transcriptional activity precedes the expression of GABA(A) receptor α6 subunit mRNA during postnatal maturation

Montpied, P., Yan, G. M., Paul, S. M. & Leslie Morrow, A., Mar 1998, In: Developmental Neuroscience. 20, 1, p. 74-82 9 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Steven Paul

Research output

Search results