Research output per year
Research output per year
- 1 - 50 out of 187 results
Search results
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2025
New directions in neurosteroid therapeutics in neuropsychiatry
Zorumski, C. F., Covey, D. F., Izumi, Y., Evers, A. S., Maguire, J. L. & Mennerick, S. J., May 2025, In: Neuroscience and Biobehavioral Reviews. 172, 106119.Research output: Contribution to journal › Review article › peer-review
Open Access -
δ-Containing GABAA receptors on parvalbumin interneurons modulate neuronal excitability and network dynamics in the mouse medial prefrontal cortex
Lu, X., Shu, H. J., Lambert, P. M., Benz, A., Zorumski, C. F. & Mennerick, S., Apr 1 2025, In: Journal of neurophysiology. 133, 4, p. 1003-1013 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme Cyp46a1 on Behavior and Hippocampal Transcription in Mouse
Shu, H. J., Ziolkowski, L. H., Salvatore, S. V., Benz, A. M., Wozniak, D., Yuede, C. M., Paul, S., Zorumski, C. F. & Mennerick, S., Mar 2024, In: Biomolecules. 14, 3, 254.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
GABAA receptor subunit composition regulates circadian rhythms in rest–wake and synchrony among cells in the suprachiasmatic nucleus
Granados-Fuentes, D., Lambert, P., Simon, T., Mennerick, S. & Herzog, E. D., Jul 30 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 31, e2400339121.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming
Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E. & Holtzman, D. M. & 1 others, , Aug 2 2024, In: Science (New York, N.Y.). 385, 6708, p. adl2992Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model
Salvatore, S. V., Ilagan, M. X. G., Shu, H., Lambert, P. M., Benz, A., Qian, M., Covey, D. F., Zorumski, C. F. & Mennerick, S., Dec 2024, In: Scientific reports. 14, 1, 1042.Research output: Contribution to journal › Article › peer-review
Open Access -
Neurosteroids: mechanistic considerations and clinical prospects
Maguire, J. L. & Mennerick, S., Jan 2024, In: Neuropsychopharmacology. 49, 1, p. 73-82 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access18 Scopus citations -
Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning
Izumi, Y., O'Dell, K. A., Cashikar, A. G., Paul, S., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Jun 2024, In: PloS one. 19, 6 June, e0304481.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation
Salvatore, S. V., Lambert, P. M., Benz, A., Rensing, N. R., Wong, M., Zorumski, C. F. & Mennerick, S., Mar 2024, In: Journal of neurophysiology. 131, 3, p. 529-540 12 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids
Izumi, Y., Reiersen, A. M., Lenze, E. J., Mennerick, S. J. & Zorumski, C. F., Dec 2024, In: Translational psychiatry. 14, 1, 474.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors
Qian, M., Xu, Y., Shu, H., Chen, Z. W., Wang, L., Zorumski, C., Evers, A. S., Mennerick, S. & Covey, D. F., Nov 13 2024, In: RSC Advances. 14, 49, p. 36352-36369 18 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2023
A common single nucleotide variant in the cytokine receptor-like factor-3 (CRLF3) gene causes neuronal deficits in human and mouse cells
Wilson, A. F., Barakat, R., Mu, R., Karush, L. L., Gao, Y., Hartigan, K. A., Chen, J. K., Shu, H., Turner, T. N., Maloney, S. E., Mennerick, S. J., Gutmann, D. H. & Anastasaki, C., Dec 15 2023, In: Human molecular genetics. 32, 24, p. 3342-3352 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Allopregnanolone Effects on Inhibition in Hippocampal Parvalbumin Interneurons
Lu, X., Lambert, P., Benz, A., Zorumski, C. F. & Mennerick, S. J., Mar 2023, In: eNeuro. 10, 3, ENEURO.0392-22.2023.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Neurosteroid enantiomers as potentially novel neurotherapeutics
Covey, D. F., Evers, A. S., Izumi, Y., Maguire, J. L., Mennerick, S. J. & Zorumski, C. F., Jun 2023, In: Neuroscience and Biobehavioral Reviews. 149, 105191.Research output: Contribution to journal › Review article › peer-review
Open Access17 Scopus citations -
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators
Lambert, P. M., Ni, R., Benz, A., Rensing, N. R., Wong, M., Zorumski, C. F. & Mennerick, S., Jan 2023, In: Neuropsychopharmacology. 48, 2, p. 371-379 9 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids
Izumi, Y., Reiersen, A. M., Lenze, E. J., Mennerick, S. J. & Zorumski, C. F., Dec 2023, In: Translational psychiatry. 13, 1, 39.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2022
Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators
Zhang, R., Li, L. S., Rao, B., Rong, H., Sun, M. Y., Yao, J., Chen, R., Zhou, Q., Mennerick, S., Raman, B. & Wang, L. V., Sep 1 2022, In: Journal of biomedical optics. 27, 9, 096004.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus
Izumi, Y., Hsu, F. F., Conway, C. R., Nagele, P., Mennerick, S. J. & Zorumski, C. F., Dec 15 2022, In: Biological Psychiatry. 92, 12, p. 964-972 9 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Physiological markers of rapid antidepressant effects of allopregnanolone
Lambert, P. M., Lu, X., Zorumski, C. F. & Mennerick, S., Feb 2022, In: Journal of Neuroendocrinology. 34, 2, e13023.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations -
2021
A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors
Ziolkowski, L., Mordukhovich, I., Chen, D. M., Chisari, M., Shu, H. J., Lambert, P. M., Qian, M., Zorumski, C. F., Covey, D. F. & Mennerick, S., Feb 1 2021, In: Neuropharmacology. 183, 108358.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol
Izumi, Y., Cashikar, A. G., Krishnan, K., Paul, S. M., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Dec 8 2021, In: Journal of Neuroscience. 41, 49, p. 10054-10064 11 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Cognitive deficits and impaired hippocampal long-term potentiation in KATPinduced DEND syndrome
Yahil, S., Wozniak, D. F., Yan, Z., Mennerick, S. & Remedi, M. S., Nov 9 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 45, e2109721118.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Editorial: Spring Hippocampal Research Conference and Beyond
Ainge, J. A., Chisari, M., Cohen, A., Mennerick, S. J., Topolnik, L. & Meier, J. C., Oct 12 2021, In: Frontiers in Molecular Neuroscience. 14, 773308.Research output: Contribution to journal › Editorial
Open Access -
Oxysterols modulate the acute effects of ethanol on hippocampal N-methyl-D-aspartate receptors, long-term potentiation, and learning
Izumi, Y., Mennerick, S., Doherty, J. J. & Zorumski, C. F., Apr 1 2021, In: Journal of Pharmacology and Experimental Therapeutics. 377, 1, p. 181-188 8 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Pharmacological and Biophysical Characteristics of Picrotoxin-Resistant, δSubunit-Containing GABAA Receptors
Shu, H. J., Lu, X., Bracamontes, J., Steinbach, J. H., Zorumski, C. F. & Mennerick, S., Nov 18 2021, In: Frontiers in Synaptic Neuroscience. 13, 763411.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity
Frye, H. E., Izumi, Y., Harris, A. N., Williams, S. B., Trousdale, C. R., Sun, M. Y., Sauerbeck, A. D., Kummer, T. T., Mennerick, S., Zorumski, C. F., Nelson, E. C., Dougherty, J. D. & Morón, J. A., Dec 1 2021, In: Biological Psychiatry. 90, 11, p. 766-780 15 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2020
Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo
Popiolek, M., Izumi, Y., Hopper, A. T., Dai, J., Miller, S., Shu, H. J., Zorumski, C. F. & Mennerick, S., Oct 29 2020, In: Frontiers in Molecular Neuroscience. 13, 568641.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABAA Receptors in Dentate Granule Neurons
Lu, X., Zorumski, C. F. & Mennerick, S., Jan 23 2020, In: Frontiers in Molecular Neuroscience. 13, 6.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
δ subunit-containing GABAA IPSCs are driven by both synaptic and diffusional GABA in mouse dentate granule neurons
Sun, M. Y., Ziolkowski, L. & Mennerick, S., Mar 1 2020, In: Journal of Physiology. 598, 6, p. 1205-1221 17 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2019
Mild chronic perturbation of inhibition severely alters hippocampal function
Sun, M. Y., Ziolkowski, L., Lambert, P., Shu, H. J., Keiser, M., Rensing, N., Warikoo, N., Martinek, M., Platnick, C., Benz, A., Bracamontes, J., Akk, G., Steinbach, J. H., Zorumski, C. F., Wong, M. & Mennerick, S., Dec 1 2019, In: Scientific reports. 9, 1, 16431.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
Zorumski, C. F., Paul, S. M., Covey, D. F. & Mennerick, S., Nov 2019, In: Neurobiology of Stress. 11, 100196.Research output: Contribution to journal › Article › peer-review
Open Access107 Scopus citations -
Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization
Chisari, M., Wilding, T. J., Brunwasser, S., Krishnan, K., Qian, M., Benz, A., Huettner, J. E., Zorumski, C. F., Covey, D. F. & Mennerick, S., Jan 2019, In: Neuropharmacology. 144, p. 91-103 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2018
A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons
Chen, D. M., Ziolkowski, L., Benz, A., Qian, M., Zorumski, C. F., Covey, D. F. & Mennerick, S., Dec 6 2018, In: Frontiers in Neuroscience. 12, 923.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation
Sobieski, C., Warikoo, N., Shu, H. J. & Mennerick, S., Apr 2018, In: PloS one. 13, 4, e0195520.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Chemogenetic isolation reveals synaptic contribution of δ GABA A receptors in mouse dentate granule neurons
Sun, M. Y., Shu, H. J., Benz, A., Bracamontes, J., Akk, G., Zorumski, C. F., Steinbach, J. H. & Mennerick, S. J., Sep 19 2018, In: Journal of Neuroscience. 38, 38, p. 8128-8145 18 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam
Cao, L. Q., Montana, M. C., Germann, A. L., Shin, D. J., Chakrabarti, S., Mennerick, S., Yuede, C. M., Wozniak, D. F., Evers, A. S. & Akk, G., Dec 1 2018, In: Scientific reports. 8, 1, 10341.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis
Warikoo, N., Brunwasser, S. J., Benz, A., Shu, H. J., Paul, S. M., Lewis, M., Doherty, J., Quirk, M., Piccio, L., Zorumski, C. F., Day, G. S. & Mennerick, S., Mar 28 2018, In: Journal of Neuroscience. 38, 13, p. 3218-3229 12 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
2017
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
Sun, M. Y., Taylor, A., Zorumski, C. F. & Mennerick, S., Mar 2017, In: PloS one. 12, 3, e0174416.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Contributions of space-clamp errors to apparent time-dependent loss of mg2+ block induced by nmda
Sun, M. Y., Chisari, M., Eisenman, L. N., Zorumski, C. F. & Mennerick, S. J., Jul 14 2017, In: Journal of neurophysiology. 118, 1, p. 532-543 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Differential presynaptic ATP supply for basal and high-demand transmission
Sobieski, C., Fitzpatrick, M. J. & Mennerick, S. J., Feb 15 2017, In: Journal of Neuroscience. 37, 7, p. 1888-1899 12 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
2016
24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival
Sun, M. Y., Linsenbardt, A. J., Emnett, C. M., Eisenman, L. N., Izumi, Y., Zorumski, C. F. & Mennerick, S., Apr 1 2016, In: Neuroscientist. 22, 2, p. 132-144 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access74 Scopus citations -
A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons
Emnett, C., Li, H., Jiang, X., Benz, A., Boggiano, J., Conyers, S., Wozniak, D. F., Zorumski, C. F., Reichert, D. E. & Mennerick, S., Dec 16 2016, In: Scientific reports. 6, 38808.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition
Jiang, X., Shu, H. J., Krishnan, K., Qian, M., Taylor, A. A., Covey, D. F., Zorumski, C. F. & Mennerick, S., Sep 1 2016, In: Neuropharmacology. 108, p. 193-206 14 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
A complement-microglial axis drives synapse loss during virus-induced memory impairment
Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., Funk, K., DeMasters, B. K., Jiang, X., Bowen, J. R., Mennerick, S., Robinson, J. K., Garbow, J. R., Tyler, K. L., Suthar, M. S. & Schmidt, R. E. & 2 others, , Jun 22 2016, In: Nature. 534, 7608, p. 538-543 6 p.Research output: Contribution to journal › Article › peer-review
Open Access494 Scopus citations -
Comparison of steroid modulation of spontaneous inhibitory postsynaptic currents in cultured hippocampal neurons and steady-state single-channel currents from heterologously expressed α1β2γ2L GABAA Receptors
Chakrabarti, S., Qian, M., Krishnan, K., Covey, D. F., Mennerick, S. & Akk, G., Apr 2016, In: Molecular pharmacology. 89, 4, p. 399-406 8 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Correcting mitochondrial fusion by manipulating mitofusin conformations
Franco, A., Kitsis, R. N., Fleischer, J. A., Gavathiotis, E., Kornfeld, O. S., Gong, G., Biris, N., Benz, A., Qvit, N., Donnelly, S. K., Chen, Y., Mennerick, S., Hodgson, L., Mochly-Rosen, D. & Dorn, G. W., Dec 1 2016, In: Nature. 540, 7631, p. 74-79 6 p.Research output: Contribution to journal › Article › peer-review
Open Access187 Scopus citations -
Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices
Sun, M. Y., Izumi, Y., Benz, A., Zorumski, C. F. & Mennerick, S., Mar 1 2016, In: Journal of neurophysiology. 115, 3, p. 1263-1272 10 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
Ketamine: NMDA receptors and beyond
Zorumski, C. F., Izumi, Y. & Mennerick, S., Nov 2 2016, In: Journal of Neuroscience. 36, 44, p. 11158-11164 7 p.Research output: Contribution to journal › Article › peer-review
Open Access170 Scopus citations -
2015
Electrophysiology of Neurons
Emnett, C. M. & Mennerick, S., Jan 30 2015, Neural Stem Cell Assays. wiley, p. 179-187 9 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel
Emnett, C. M., Eisenman, L. N., Mohan, J., Taylor, A. A., Doherty, J. J., Paul, S. M., Zorumski, C. F. & Mennerick, S., Mar 2015, In: British Journal of Pharmacology. 172, 5, p. 1333-1347 15 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations