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Steven Mennerick

Professor of Psychiatry, Professor of Neuroscience

    • 8261 Citations
    1994 …2020

    Research output per year

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    Research interests

    We study chemical excitation and inhibition by neurotransmitters in the central nervous system. Chemical transmission requires a fine balance as over-excitation or over-inhibition is detrimental to function and survival of neurons. In one project, we are studying the role of astrocytes in supporting the development and maintenance of chemical transmission. One branch of this project is studying the role of astrocytes in neuroenergetics. Another major emphasis is a collaborative effort to understand the mechanisms by which endogenous neuroactive steroids directly modulate GABA and glutamate receptor function. A final project uses a foreign dopamine-gated ion channel to interrogate and control dopamine transmission. For our studies we use electrophysiological, molecular, chemical biology and imaging techniques applied to neurons in culture, to brain slices, and to animals.

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    Research Output

    Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABAA Receptors in Dentate Granule Neurons

    Lu, X., Zorumski, C. F. & Mennerick, S., Jan 23 2020, In : Frontiers in Molecular Neuroscience. 13, 6.

    Research output: Contribution to journal › Article

    Open Access

    • δ subunit-containing GABAA IPSCs are driven by both synaptic and diffusional GABA in mouse dentate granule neurons

    Sun, M. Y., Ziolkowski, L. & Mennerick, S., Mar 1 2020, In : Journal of Physiology. 598, 6, p. 1205-1221 17 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Mild chronic perturbation of inhibition severely alters hippocampal function

    Sun, M. Y., Ziolkowski, L., Lambert, P., Shu, H. J., Keiser, M., Rensing, N., Warikoo, N., Martinek, M., Platnick, C., Benz, A., Bracamontes, J., Akk, G., Steinbach, J. H., Zorumski, C. F., Wong, M. & Mennerick, S., Dec 1 2019, In : Scientific reports. 9, 1, 16431.

    Research output: Contribution to journal › Article

    Open Access

    • Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

    Zorumski, C. F., Paul, S. M., Covey, D. F. & Mennerick, S., Nov 2019, In : Neurobiology of Stress. 11, 100196.

    Research output: Contribution to journal › Article

    Open Access
    • 7 Scopus citations

    Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization

    Chisari, M., Wilding, T. J., Brunwasser, S., Krishnan, K., Qian, M., Benz, A., Huettner, J. E., Zorumski, C. F., Covey, D. F. & Mennerick, S., Jan 2019, In : Neuropharmacology. 144, p. 91-103 13 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations