Research output per year
Research output per year
Personal profile
Research interests
Our research focus is abnormalities of the airway epithelial cell differentiation that characterize lung diseases such as bronchitis, bronchiectasis, respiratory virus and bacterial infection. We are particularly interested in mechanisms of ciliated cell differentiation and cilia biogenesis. These studies are linked to investigation of the genetic basis of lung disease in patient populations with known or suspected defects in cilia, co-called ciliopathies.
Clinical interests
Critical care medicine, ARDS, septic shock, clinical toxicology, cystic fibrosis, primary ciliary dyskinesia
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Airway Disease Modeling with Gene-Edited Human Basal Cell Transplantation
Berical, A. C., Kiyokawa, H., Beermann, M. L., Wallman, D., Cherfane, G., Dunphy, V., Pan, J., Tilston-Lunel, A., Varelas, X., Horani, A., Brody, S. L., Kotton, D. N. & Hawkins, F. J., Jan 2025, In: American journal of respiratory and critical care medicine. 211, 1, p. 131-134 4 p.Research output: Contribution to journal › Letter › peer-review
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Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma
Chen, L., A. Hoefel, G., Pathinayake, P. S., Reid, A., Pillar, A. L., Kelly, C., Tan, H. Y., Ali, A., Kim, R. Y., Hansbro, P. M., Brody, S. L., Foster, P. S., Horvat, J. C., Riveros, C., Awatade, N., Wark, P. A. B. & Kaiko, G. E., Jan 2025, In: Respirology. 30, 1, p. 25-40 16 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25
Kalita, P., Khatavkar, O., Uwase, G., Korshunova, Y., Hu, Y., Wagner, N. D., Xu, J., Pan, J., Nix, J. C., Gross, M. L., Brody, S. L., Borek, D., Amarasinghe, G. K., Payton, J. E. & Leung, D. W., Dec 2025, In: Nature communications. 16, 1, 2883.Research output: Contribution to journal › Article › peer-review
Open Access -
Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia
Brody, S. L., Pan, J., Huang, T., Xu, J., Xu, H., Koenitizer, J. R., Brennan, S. K., Nanjundappa, R., Saba, T. G., Rumman, N., Berical, A., Hawkins, F. J., Wang, X., Zhang, R., Mahjoub, M. R., Horani, A. & Dutcher, S. K., Jan 29 2025, In: Science translational medicine. 17, 783, eadp5173.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models
Puray-Chavez, M., Eschbach, J. E., Xia, M., LaPak, K. M., Zhou, Q., Jasuja, R., Pan, J., Xu, J., Zhou, Z., Mohammed, S., Wang, Q., Lawson, D. Q., Djokic, S., Hou, G., Ding, S., Brody, S. L., Major, M. B., Goldfarb, D. & Kutluay, S. B., Dec 2024, In: Nature communications. 15, 1, 8394.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations