• 4161 Citations

Research output per year

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Personal profile

Research interests

Protein homeostasis or proteostasis is a highly complex and interconnected pathway that regulates the fate of a protein by controlling its biogenesis, folding, trafficking and degradation. Maintenance of proper cellular proteostasis is crucial for ensuring normal development, healthy aging and resistance to environmental stresses. Excessive accumulation of misfolded proteins can disrupt proteostasis and is the cause of many diseases including Alzheimer’s disease, Huntington’s disease and Parkinson’s disease. The cellular mechanisms that are triggered to cope with misfolded proteins are complex and vary depending on the nature of the misfolded protein, its subcellular localization, and the protein degradation pathways employed. A global understanding of the cellular responses could enable the development of novel therapeutic strategies that restore proteostasis and normal health. My current research is focused on modeling protein aggregation disorders in C. elegans and employing innovative, high-throughput strategies to 1) gain a comprehensive understanding of the genetic mechanisms that underlie the disease, and 2) identify therapeutic compounds.

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Research Output

Mechanisms of action of autophagy modulators dissected by quantitative systems pharmacology analysis

Shi, Q., Pei, F., Silverman, G. A., Pak, S. C., Perlmutter, D. H., Liu, B. & Bahar, I., Apr 1 2020, In : International journal of molecular sciences. 21, 8, 2855.

Research output: Contribution to journalArticle

Open Access
  • An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

    Wang, Y., Cobanoglu, M. C., Li, J., Hidvegi, T., Hale, P., Ewing, M., Chu, A. S., Gong, Z., Muzumdar, R., Pak, S. C., Silverman, G. A., Bahar, I. & Perlmutter, D. H., Jan 2019, In : PloS one. 14, 1, e0209748.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. Elegans

    Thomas, B. J., Wight, I. E., Chou, W. Y. Y., Moreno, M., Dawson, Z., Homayouni, A., Huang, H., Kim, H., Jia, H., Buland, J. R., Wambach, J. A., Cole, F. S., Pak, S. C., Silverman, G. A. & Luke, C. J., Mar 2019, In : PloS one. 14, 3, e0214257.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations
  • 1 Scopus citations

    De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia

    Undiagnosed Diseases Network, Aug 1 2019, In : American journal of human genetics. 105, 2, p. 413-424 12 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations