Research output per year
Research output per year
Personal profile
Research interests
I head a translational research group focused on the pathogenesis of myeloproliferative neoplasms (MPNs). My laboratory research employs human patient samples and animal models to study the initiation, development, and progression of MPNs, with a particular focus on inflammatory signaling networks in MPNs. I have extensive clinical experience in the diagnosis and management of MPN patients, and I have contributed to numerous clinical trials investigating novel targeted therapies for MPN patients. The long-term objective of our work is to translate the findings from his laboratory research into improved therapies for MPN patients.
I am also co-Head of the Immunomonitoring Laboratory (IML), a shared resource operated by the Washington University Center for Human Immunology and Immunotherapy. I oversee flow/mass cytometry (Fortessa, CyTOF), and multiplex imaging (Hyperion, CODEX) applications within the IML. I am involved in several collaborative projects utilizing these approaches.
Clinical interests
Myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, myelofibrosis, chronic myeloid leukemia, chronic myelomonocytic leukemia, systemic mastocytosis, hypereosinophilic syndrome
Available to Mentor:
- High School Students
- Undergraduate Students
- Post-Baccalaureate Students
- PhD Students
- Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies
He, F., Lin, S., Gao, B., Ramesh, V., Kim, A. B., Kong, T., Fisher, D. A. C., Letson, C. T., Brakhane, M., Fulbright, M., Yu, Y., Sardiello, M., Di Paola, J., Sykes, S. M. & Oh, S. T., Dec 2026, In: Cell Communication and Signaling. 24, 1, 61.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma
Immune Atlas Consortium, Jan 2026, In: Nature Cancer. 7, 1, p. 224-246 23 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Scopus citations -
Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial
Kong, T., Mabry, A., Highkin, M., Wang, A. Z., Hoog, J., Guo, Z., Gonzales-Gonzales, A., Thomas, S., Song, Y., Gao, F., Opyrchal, M., Peterson, L., Ademuyiwa, F., Margenthaler, J., Aft, R., Glover-Collins, K., Nehring, L., Tao, Y., Sanati, S. & Hagemann, I. S. & 14 others, , Dec 2026, In: Nature communications. 17, 1, 949.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Efficacy and safety of avapritinib in advanced systemic mastocytosis: 4-year follow-up of the PATHFINDER study
Gotlib, J., Reiter, A., Radia, D. H., Álvarez-Twose, I., Deininger, M. W., George, T. I., Panse, J., Mital, A., Pettit, K. M., Vannucchi, A. M., Platzbecker, U., Hermine, O., Elshoury, A., Livideanu, C. B., Mesa, R., Ustun, C., Triggiani, M., Dybedal, I., Jurcic, J. G. & Zanotti, R. & 15 others, , May 26 2026, In: Blood Advances. 10, 10, p. 3676-3689 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Galectin-1 fuels monocyte hyperinflammation and is a novel therapeutic target in myeloproliferative neoplasms
He, F., Lin, S., Kong, T., Fisher, D. A. C., Kim, A. B., Ramesh, V., Brakhane, M., Letson, C. T., Grodzielski, M., Cox, M. J., Fulbright, M. C., Xiong, Y., Yu, L. Y., Yu, Y., Ashworth, K. J., Siner, J. I., Engeler, A., Laranjeira, A. B. A., Sykes, S. M. & Di Paola, J. & 1 others, , Sep 24 2026, In: Blood. 148, 13, p. 1708-1722 15 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations