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Research interests

I head a translational research group focused on the pathogenesis of myeloproliferative neoplasms (MPNs). My laboratory research employs human patient samples and mouse models to study the initiation, development, and progression of MPNs. A major focus of the laboratory is to utilize single cell mass cytometry to interrogate dysregulated cytokine-signaling networks in MPNs. We also utilize next-generation sequencing approaches to understand genetic complexity and clonal evolution in MPNs. I have extensive clinical experience in the diagnosis and management of MPN patients, and have participated in numerous clinical trials investigating novel targeted therapies for MPN patients.

I am also co-Head of the Immunomonitoring Laboratory (IML), a shared resource operated by the Washington University Center for Human Immunology and Immunotherapy Programs (CHiiPs). I oversee cytometry and multiplex imaging applications within the IML, including the administration of two Fluidigm CyTOF instruments, a Fluidigm Hyperion Imaging System, and an Akoya CODEX device. I am involved in a number of collaborative projects utilizing these technologies.

Areas of Clinical Interest

Myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, myelofibrosis, chronic myeloid leukemia, chronic myelomonocytic leukemia, systemic mastocytosis, hypereosinophilic syndrome

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