Stephen Oh

Associate Professor of Medicine, Associate Professor of Pathology and Immunology

    • 2215 Citations
    20012020

    Research output per year

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    Personal profile

    Research interests

    I head a translational research group focused on the pathogenesis of myeloproliferative neoplasms (MPNs). My laboratory research employs human patient samples and mouse models to study the initiation, development, and progression of MPNs. A major focus of the laboratory is to utilize single cell mass cytometry to interrogate dysregulated cytokine-signaling networks in MPNs. We also utilize next-generation sequencing approaches to understand genetic complexity and clonal evolution in MPNs. I have extensive clinical experience in the diagnosis and management of MPN patients, and have participated in numerous clinical trials investigating novel targeted therapies for MPN patients. I am also co-Head of the Immunomonitoring Laboratory (IML), a shared resource operated by the Washington University Center for Human Immunology and Immunotherapy Programs (CHiiPs). I oversee cytometry and multiplex imaging applications within the IML, including the administration of two Fluidigm CyTOF instruments, a Fluidigm Hyperion Imaging System, and an Akoya CODEX device. I am involved in a number of collaborative projects utilizing these technologies.

    Areas of Clinical Interest

    Myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, myelofibrosis, chronic myeloid leukemia, chronic myelomonocytic leukemia, systemic mastocytosis, hypereosinophilic syndrome

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    Research Output

    ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial

    Oh, S. T., Talpaz, M., Gerds, A. T., Gupta, V., Verstovsek, S., Mesa, R., Miller, C. B., Rivera, C. E., Fleischman, A. G., Goel, S., Heaney, M. L., Connell, C. O., Arcasoy, M. O., Zhang, Y., Kawashima, J., Ganz, T., Kowalski, M. & Brachmann, C. B., Sep 2020, In : Blood Advances. 4, 18, p. 4282-4291 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Efficacy of ruxolitinib in patients with chronic neutrophilic leukemia and atypical chronic myeloid leukemia

    Dao, K. H. T., Gotlib, J., Deininger, M. M. N., Oh, S. T., Cortes, J. E., Collins, R. H., Winton, E. F., Parker, D. R., Lee, H., Schultz, A. R., Stevens, S. S., Brockett, C., Subbiah, N., Press, R. D., Raess, P. W., Cascio, M., Dunlap, J., Chen, Y., Degnin, C., Maxson, J. E. & 4 others, Tognon, C. E., Macey, T., Druker, B. J. & Tyner, J. W., Apr 1 2020, In : Journal of Clinical Oncology. 38, 10, p. 1006-1018 13 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Treatment Patterns and Blood Counts in Patients With Polycythemia Vera Treated With Hydroxyurea in the United States: An Analysis From the REVEAL Study

    Grunwald, M. R., Kuter, D. J., Altomare, I., Burke, J. M., Gerds, A. T., Walshauser, M. A., Savona, M. R., Stein, B., Oh, S. T., Colucci, P., Parasuraman, S., Paranagama, D. & Mesa, R., Apr 2020, In : Clinical Lymphoma, Myeloma and Leukemia. 20, 4, p. 219-225 7 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Unraveling the architecture of classic hodgkin lymphoma one cell at a time

    Fisher, D. A. C. & Oh, S. T., Mar 2020, In : Cancer discovery. 10, 3, p. 342-344 3 p.

    Research output: Contribution to journalArticle

  • Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling

    Fisher, D. A. C., Miner, C. A., Engle, E. K., Hu, H., Collins, T. B., Zhou, A., Allen, M. J., Malkova, O. N. & Oh, S. T., Aug 1 2019, In : Leukemia. 33, 8, p. 1978-1995 18 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations