Stephen Moerlein

2021

Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers

Criswell, S. R., Searles Nielsen, S., Dlamini, W. W., Warden, M. N., Perlmutter, J. S., Sheppard, L., Moerlein, S. M., Lenox-Krug, J., Checkoway, H. & Racette, B. A., Jul 1 2021, In: Toxicological Sciences. 182, 1, p. 132-141 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2020

[11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers

Criswell, S. R., Nielsen, S. S., Warden, M. N., Perlmutter, J. S., Moerlein, S. M., Sheppard, L., Lenox-Krug, J., Checkoway, H. & Racette, B. A., Oct 1 2020, In: Journal of occupational and environmental medicine. 62, 10, p. 788-794 7 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2018

[ ¹⁸ F]FDOPA positron emission tomography in manganese-exposed workers

Criswell, S. R., Nielsen, S. S., Warden, M., Perlmutter, J. S., Moerlein, S. M., Flores, H. P., Huang, J., Sheppard, L., Seixas, N., Checkoway, H. & Racette, B. A., Jan 2018, In: NeuroToxicology. 64, p. 43-49 7 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Selective D2 receptor PET in manganese-exposed workers

Criswell, S. R., Warden, M. N., Nielsen, S. S., Perlmutter, J. S., Moerlein, S. M., Sheppard, L., Lenox-Krug, J., Checkoway, H. & Racette, B. A., Sep 11 2018, In: Neurology. 91, 11, p. E1022-E1030

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2017

Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia

Eisenstein, S. A., Bogdan, R., Chen, L., Moerlein, S. M., Black, K. J., Perlmutter, J. S., Hershey, T. & Barch, D. M., Mar 1 2017, In: Journal of Psychiatric Research. 86, p. 9-17 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2016

Automated production of [¹⁸F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

Yue, X., Bognar, C., Zhang, X., Gaehle, G. G., Moerlein, S. M., Perlmutter, J. S. & Tu, Z., Jan 1 2016, In: Applied Radiation and Isotopes. 107, p. 40-46 7 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status

Eisenstein, S. A., Bogdan, R., Love-Gregory, L., Corral-Frías, N. S., Koller, J. M., Black, K. J., Moerlein, S. M., Perlmutter, J. S., Barch, D. M. & Hershey, T., Oct 1 2016, In: Synapse. 70, 10, p. 418-431 14 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Sweet dopamine: Sucrose preferences relate differentially to striatal D₂ receptor binding and age in obesity

Pepino, M. Y., Eisenstein, S. A., Bischoff, A. N., Klein, S., Moerlein, S. M., Perlmutter, J. S., Black, K. J. & Hershey, T., Sep 1 2016, In: Diabetes. 65, 9, p. 2618-2623 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2015

Emotional eating phenotype is associated with central dopamine D₂ receptor binding independent of body mass index

Eisenstein, S. A., Bischoff, A. N., Gredysa, D. M., Antenor-Dorsey, J. A. V., Koller, J. M., Al-Lozi, A., Pepino, M. Y., Klein, S., Perlmutter, J. S., Moerlein, S. M., Black, K. J. & Hershey, T., Jun 12 2015, In: Scientific reports. 5, 11283.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Insulin, central dopamine D2 receptors, and monetary reward discounting in obesity

Eisenstein, S. A., Gredysa, D. M., Antenor-Dorsey, J. A., Green, L., Arbeláez, A. M., Koller, J. M., Black, K. J., Perlmutter, J. S., Moerlein, S. M. & Hershey, T., Jul 20 2015, In: PloS one. 10, 7, e0133621.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Neuroimaging analysis of the dopamine basis for apathetic behaviors in an MPTP-lesioned primate model

Tian, L. L., Xia, Y., Flores, H. P., Campbell, M. C., Moerlein, S. M. & Perlmutter, J. S., Jul 2 2015, In: PloS one. 10, 7, e0132064.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2014

Carboxyfullerene neuroprotection postinjury in parkinsonian nonhuman primates

Dugan, L. L., Tian, L. L., Quick, K. L., Hardt, J. I., Karimi, M., Brown, C., Loftin, S., Flores, H., Moerlein, S. M., Polich, J., Tabbal, S. D., Mink, J. W. & Perlmutter, J. S., Sep 1 2014, In: Annals of neurology. 76, 3, p. 393-402 10 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Spatial reorganization of putaminal dopamine D₂-like receptors in cranial and hand dystonia

Black, K. J., Snyder, A. Z., Mink, J. W., Tolia, V. N., Revilla, F. J., Moerlein, S. M. & Perlmutter, J. S., Feb 10 2014, In: PloS one. 9, 2, e88121.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2013

A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[¹¹C]methyl)benperidol

Eisenstein, S. A., Antenor-Dorsey, J. A. V., Gredysa, D. M., Koller, J. M., Bihun, E. C., Ranck, S. A., Arbeláez, A. M., Klein, S., Perlmutter, J. S., Moerlein, S. M., Black, K. J. & Hershey, T., Nov 2013, In: Synapse. 67, 11, p. 748-756 9 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia

Karimi, M., Moerlein, S. M., Videen, T. O., Su, Y., Flores, H. P. & Perlmutter, J. S., Dec 2013, In: Movement Disorders. 28, 14, p. 2002-2006 5 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Validation of midbrain positron emission tomography measures for nigrostriatal neurons in macaques

Brown, C. A., Karimi, M. K., Tian, L., Flores, H., Su, Y., Tabbal, S. D., Loftin, S. K., Moerlein, S. M. & Perlmutter, J. S., Oct 2013, In: Annals of neurology. 74, 4, p. 602-610 9 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Validation of nigrostriatal positron emission tomography measures: Critical limits

Karimi, M., Tian, L., Brown, C. A., Flores, H. P., Loftin, S. K., Videen, T. O., Moerlein, S. M. & Perlmutter, J. S., Mar 2013, In: Annals of neurology. 73, 3, p. 390-396 7 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

2012

Characterization of extrastriatal D2 in vivo specific binding of [¹⁸F](N-methyl)benperidol using PET

Eisenstein, S. A., Koller, J. M., Piccirillo, M., Kim, A., Antenor-Dorsey, J. A. V., Videen, T. O., Snyder, A. Z., Karimi, M., Moerlein, S. M., Black, K. J., Perlmutter, J. S. & Hershey, T., Sep 2012, In: Synapse. 66, 9, p. 770-780 11 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Dopamine pathway loss in nucleus accumbens and ventral tegmental area predicts apathetic behavior in MPTP-lesioned monkeys

Brown, C. A., Campbell, M. C., Karimi, M., Tabbal, S. D., Loftin, S. K., Tian, L. L., Moerlein, S. M. & Perlmutter, J. S., Jul 2012, In: Experimental Neurology. 236, 1, p. 190-197 8 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Reduced uptake of FDOPA PET in end-stage liver disease with elevated manganese levels

Criswell, S. R., Perlmutter, J. S., Crippin, J. S., Videen, T. O., Moerlein, S. M., Flores, H. P., Birke, A. M. & Racette, B. A., Mar 2012, In: Archives of neurology. 69, 3, p. 394-397 4 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2011

Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

Karimi, M., Moerlein, S. M., Videen, T. O., Luedtke, R. R., Taylor, M., Mach, R. H. & Perlmutter, J. S., Jan 2011, In: Movement Disorders. 26, 1, p. 100-106 7 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Reduced uptake of [18F]FDOPA PET in asymptomatic welders with occupational manganese exposure

Criswell, S. R., Perlmutter, J. S., Videen, T. O., Moerlein, S. M., Flores, H. P., Birke, A. M. & Racette, B. A., Apr 12 2011, In: Neurology. 76, 15, p. 1296-1301 6 p.

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

2008

Radiation dosimetry of N-([¹¹C]methyl)benperidol as determined by whole-body PET imaging of primates

Antenor-Dorsey, J. A. V., Laforest, R., Moerlein, S. M., Videen, T. O. & Perlmutter, J. S., Apr 2008, In: European Journal of Nuclear Medicine and Molecular Imaging. 35, 4, p. 771-778 8 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Validation of the reference tissue model for estimation of dopaminergic D₂-like receptor binding with [¹⁸F](N-methyl)benperidol in humans

Antenor-Dorsey, J. A. V., Markham, J., Moerlein, S. M., Videen, T. O. & Perlmutter, J. S., Apr 2008, In: Nuclear Medicine and Biology. 35, 3, p. 335-341 7 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2006

[¹⁸F]FDOPA PET as an endophenotype for Parkinson's disease linkage studies

Racette, B. A., Good, L., Antenor, J. A., McGee-Minnich, L., Moerlein, S. M., Videen, T. O. & Perlmutter, J. S., Apr 5 2006, In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 141 B, 3, p. 245-249 5 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced acute transient dystonia in monkeys associated with low striatal dopamine

Tabbal, S. D., Mink, J. W., Antenor, J. A. V., Carl, J. L., Moerlein, S. M. & Perlmutter, J. S., 2006, In: Neuroscience. 141, 3, p. 1281-1287 7 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

2005

[¹⁸F]FDOPA PET and clinical features in Parkinsonism due to manganism

Racette, B. A., Antenor, J. A., McGee-Minnich, L., Moerlein, S. M., Videen, T. O., Kotagal, V. & Perlmutter, J. S., Apr 2005, In: Movement Disorders. 20, 4, p. 492-496 5 p.

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

2004

Decreased hippocampal 5-HT_2A receptor binding in major depressive disorder: In vivo measurement with [¹⁸F]altanserin positron emission tomography

Mintun, M. A., Sheline, Y. I., Moerlein, S. M., Vlassenko, A. G., Huang, Y. & Snyder, A. Z., Feb 1 2004, In: Biological Psychiatry. 55, 3, p. 217-224 8 p.

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Decreased hippocampal 5-HT_2A receptor binding in older depressed patients using [¹⁸F]altanserin positron emission tomography

Sheline, Y. I., Mintun, M. A., Barch, D. M., Wilkins, C., Snyder, A. Z. & Moerlein, S. M., Dec 2004, In: Neuropsychopharmacology. 29, 12, p. 2235-2241 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Pathophysiology of parkinsonism due to hydrocephalus

Racette, B. A., Esper, G. J., Antenor, J., Black, K. J., Burkey, A., Moerlein, S. M., Videen, T. O., Kotagal, V., Ojemann, J. G. & Perlmutter, J. S., Nov 2004, In: Journal of Neurology, Neurosurgery and Psychiatry. 75, 11, p. 1617-1619 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Radiosynthesis of (N-[¹¹C]methyl)benperidol for PET investigation of D2 receptor binding

Moerlein, S. M., Perlmutter, J. S. & Welch, M. J., 2004, In: Radiochimica Acta. 92, 4-6, p. 333-339 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2002

Greater loss of 5-HT_2A receptors in midlife than in late life

Sheline, Y. I., Mintun, M. A., Moerlein, S. M. & Snyder, A. Z., 2002, In: American Journal of Psychiatry. 159, 3, p. 430-435 6 p.

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Robotic preparation of Sodium Acetate C 11 Injection for use in clinical PET

Moerlein, S. M., Gaehle, G. G. & Welch, M. J., 2002, In: Nuclear Medicine and Biology. 29, 5, p. 613-621 9 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2001

Welding-related parkinsonism: Clinical-features, treatment, and pathophysiology

Racette, B. A., McGee-Minnich, L., Moerlein, S. M., Mink, J. W., Videen, T. O. & Perlmutter, J. S., Jan 9 2001, In: Neurology. 56, 1, p. 8-13 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

325 Scopus citations

1998

Decreased [18F]spiperone binding in putamen in dystonia.

Perlmutter, J. S., Stambuk, M. K., Markham, J., Black, K. J., McGee-Minnich, L., Jankovic, J. & Moerlein, S. M., 1998, In: Advances in neurology. 78, p. 161-168 8 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

USP tandards for flumazenil c 11 injection

Moerlein, S. M., Mintun, M. A., Perlmutter, J. S., Welch, M. J. & Siegel, B. A., 1998, In: Pharmacopeial Forum. 24, 3, p. 6360-6365 6 p.

Research output: Contribution to journal › Article › peer-review

1997

Decreased [¹⁸F]spiperone binding in putamen in idiopathic focal dystonia

Perlmutter, J. S., Stambuk, M. K., Markham, J., Black, K. J., McGee-Minnich, L., Jankovic, J. & Moerlein, S. M., 1997, In: Journal of Neuroscience. 17, 2, p. 843-850 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

203 Scopus citations

In vivo kinetics of [¹⁸F](N-methyl)benperidol: A novel PET tracer for assessment of dopaminergic D2-like receptor binding

Moerlein, S. M., Perlmutter, J. S., Markham, J. & Welch, M. J., Aug 1997, In: Journal of Cerebral Blood Flow and Metabolism. 17, 8, p. 833-845 13 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Radiation dosimetry of [¹⁸F](N-methyl)benperidol as determined by whole-body PET imaging of primates

Moerlein, S. M., Perlmutter, J. S., Cutler, P. D. & Welch, M. J., May 1997, In: Nuclear Medicine and Biology. 24, 4, p. 311-318 8 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

1995

Specific, reversible binding of [¹⁸F]benperidol to baboon D₂ receptors: PET evaluation of an improved ¹⁸F-labeled ligand

Moerlein, S. M., Perlmutter, J. S. & Welch, M. J., Aug 1995, In: Nuclear Medicine and Biology. 22, 6, p. 809-815 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

1994

First-pass extraction fraction of iodine-123 labeled perfusion tracers in living primate brain

Moerlein, S. M., Perlmutter, J. S., Welch, M. J. & Raichle, M. E., Aug 1994, In: Nuclear Medicine and Biology. 21, 6, p. 847-855 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

N-alkylated analogues of [F-18]benperidol as dopaminergic D-2 receptor ligands

Moerlein, S. M., Perlmutter, J. S., Bockhorst, J. L., Parkinson, D. & Welch, M. J., Jan 1 1994, In: Journal of Labelled Compounds and Radiopharmaceuticals. 35, p. 462-463 2 p.

Research output: Contribution to journal › Article › peer-review

1993

Automated production of oxygen-15 labeled butanol for PET measurement of regional cerebral blood flow

Moerlein, S. M., Gaehle, G. G., Lechner, K. R., Bera, R. K. & Welch, M. J., Sep 1993, In: Applied Radiation and Isotopes. 44, 9, p. 1213-1218 6 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Metabolism in vitro of radioiodinated N-isopropyl-p-iodoamphetamine by isolated hepatocytes

Moerlein, S. M., Weisman, R. A., Beck, D., Li, A. P. & Welch, M. J., Jan 1993, In: Nuclear Medicine and Biology. 20, 1, p. 49-56 8 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

1992

Binding of 5-(2′-[¹⁸F]fluoroenthyl)flumazenil to central benzodiazepine receptors measured in living baboon by positron emission tomography

Moerlein, S. M. & Perlmutter, J. S., Jul 21 1992, In: European Journal of Pharmacology. 218, 1, p. 109-115 7 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Functional recovery after coronary revascularization for chronic coronary artery disease is dependent on maintenance of oxidative metabolism

Gropler, R. J., Geltman, E. M., Sampathkumaran, K., Pérez, J. E., Moerlein, S. M., Sobel, B. E., Bergmann, S. R. & Siegel, B. A., Sep 1992, In: Journal of the American College of Cardiology. 20, 3, p. 569-577 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

Production of fluorine-18 labeled (3-N-methyl)benperidol for PET investigation of cerebral dopaminergic receptor binding

Moerlein, S. M., Banks, W. R. & Parkinson, D., Jul 1992, In: International Journal of Radiation Applications and Instrumentation. Part. 43, 7, p. 913-917 5 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Specific binding of 3N-(2′-[¹⁸F]fluoroethyl)benperidol to primate cerebral dopaminergic D₂ receptors demonstrated in vivo by PET

Moerlein, S. M. & Perlmutter, J. S., Dec 14 1992, In: Neuroscience Letters. 148, 1-2, p. 97-100 4 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

1991

Central serotonergic S₂ binding in Papio anubis measured in vivo with N-ω-[¹⁸F]fluoroethylketanserin and PET

Moerlein, S. M. & Perlmutter, J. S., Feb 11 1991, In: Neuroscience Letters. 123, 1, p. 23-26 4 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Metabolic imaging with gallium-68- and indium-111-labeled low-density lipoprotein

Moerlein, S. M., Daugherty, A., Sobel, B. E. & Welch, M. J., 1991, In: Journal of Nuclear Medicine. 32, 2, p. 300-307 8 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Stephen Moerlein

Research output

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