Stephen Moerlein

Associate Professor of Radiology, Associate Professor of Biochemistry and Molecular Biophysics

    • 2954 Citations
    1981 …2018

    Research output per year

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    Personal profile

    Research interests

    Research interests lie in the general area of labeled tracer development for nuclear medicine imaging, especially positron-emission tomography (PET). Developmental effort begins with synthesis of target structures, preclinical screening that involves in vitro biochemistry and pharmacological testing, and ex vivo biodistribution studies in small animals. Promising tracers are then examined by in vivo imaging of animal subjects and tracer kinetic modeling. The final step in the transition of a radiochemical into a labeled drug takes into account radiation dosimetry, pharmaceutical quality, and the development of automated production to streamline delivery to human subjects. Each of these aspects of radiopharmaceutical development are investigated, with a primary emphasis in novel agents for evaluation of pathological processes in neurology,psychiatry and oncology.

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    Research Output

    [ 18 F]FDOPA positron emission tomography in manganese-exposed workers

    Criswell, S. R., Nielsen, S. S., Warden, M., Perlmutter, J. S., Moerlein, S. M., Flores, H. P., Huang, J., Sheppard, L., Seixas, N., Checkoway, H. & Racette, B. A., Jan 2018, In : NeuroToxicology. 64, p. 43-49 7 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Selective D2 receptor PET in manganese-exposed workers

    Criswell, S. R., Warden, M. N., Nielsen, S. S., Perlmutter, J. S., Moerlein, S. M., Sheppard, L., Lenox-Krug, J., Checkoway, H. & Racette, B. A., Sep 11 2018, In : Neurology. 91, 11, p. E1022-E1030

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

    Yue, X., Bognar, C., Zhang, X., Gaehle, G. G., Moerlein, S. M., Perlmutter, J. S. & Tu, Z., Jan 1 2016, In : Applied Radiation and Isotopes. 107, p. 40-46 7 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Erratum: Insulin, central dopamine D2 receptors, and monetary reward discounting in obesity (PLoS ONE (2016) 11:1 (e0147063)

    Eisenstein, S. A., Gredysa, D. M., Antenor-Dorsey, J. A., Green, L., Arbeláez, A. M., Koller, J. M., Black, K. J., Perlmutter, J. S., Moerlein, S. M. & Hershey, T., Jan 8 2016, In : PloS one. 11, 1, e0147063.

    Research output: Contribution to journalComment/debate

    Open Access