Stephen Beverley

Ernest St. John Simms Distinguished Professor of Molecular Microbiology

    • 16601 Citations
    1980 …2019

    Research output per year

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    Personal profile

    Research interests

    Our laboratory is interested in tropical infectious diseases, focusing on the protozoan parasite Leishmania which afflicts more than 10 million people world wide. It is a common opportunistic AIDS disease around the Mediterranean and several thousand cases are emerging in US soldiers returning from the Mideast. We have developed a wide array of molecular genetic, genomic, cell biological and biochemical tools of the genome, and are applying these towards dissecting how the parasites carry out their infectious cycle in both mammals and the sand fly vector which transmits them. We are interested in parasite molecules which play key roles in antigenic variation, macrophage survival, and disease progression, many of which constitute the surface glycocalyx. As our work is carried directly in a serious pathogen, it is perhaps unsurprising that many findings have potential clinical applications. Several of the ‘virulence’ pathways above as well as other metabolic pathways show great promise for development of selective chemotherapies. Our ability to modify the parasite genome easily permits us to generate attenuated candidate vaccine lines. One early line lacking the key metabolic enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS) is slated to be tested shortly in one of the first such tests with Leishmania in humans in the Mideast. Recent studies yielded a remarkable parasite (lpg2-) able to indefinitely ‘persist without pathology’, while simultaneously showing great promise for long term and effective immunization in mouse models. Now we are studying how they accomplish this feat mechanistically, and how to extend these results to human vaccines.

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    Research Output

    Dramatic changes in gene expression in different forms of Crithidia fasciculata reveal potential mechanisms for insect-specific adhesion in kinetoplastid parasites

    Filosa, J. N., Berry, C. T., Ruthel, G., Beverley, S. M., Warren, W. C., Tomlinson, C., Myler, P. J., Dudkin, E. A., Povelones, M. L. & Povelones, M., Jul 2019, In : PLoS neglected tropical diseases. 13, 7, e0007570.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome

    de Carvalho, R. V. H., Andrade, W. A., Lima-Junior, D. S., Dilucca, M., de Oliveira, C. V., Wang, K., Nogueira, P. M., Rugani, J. N., Soares, R. P., Beverley, S. M., Shao, F. & Zamboni, D. S., Jan 8 2019, In : Cell Reports. 26, 2, p. 429-437.e5

    Research output: Contribution to journalArticle

    Open Access
  • 25 Scopus citations

    Mannogen-ing Central Carbon Metabolism by Leishmania

    Zhang, K. & Beverley, S. M., Dec 2019, In : Trends in Parasitology. 35, 12, p. 947-949 3 p.

    Research output: Contribution to journalShort survey

  • TLR2 Signaling in Skin Nonhematopoietic Cells Induces Early Neutrophil Recruitment in Response to Leishmania major Infection

    Ronet, C., Passelli, K., Charmoy, M., Scarpellino, L., Myburgh, E., Hauyon La Torre, Y., Turco, S., Mottram, J. C., Fasel, N., Luther, S. A., Beverley, S. M., Launois, P. & Tacchini-Cottier, F., Jun 2019, In : Journal of Investigative Dermatology. 139, 6, p. 1318-1328 11 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in leishmania

    Inbar, E., Shaik, J., Iantorno, S. A., Romano, A., Nzelu, C. O., Owens, K., Sanders, M. J., Dobson, D., Cotton, J. A., Grigg, M. E., Beverley, S. M. & Sacks, D., May 2019, In : PLoS genetics. 15, 5, e1008042.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations