• Source: Scopus
19972020

Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

The cardiac conduction system generates and propagates electrical impulses within the heart, and cells of the conduction network arise from lineage specification of cardiomyocyte progenitors. We are seeking to understand the mechanisms regulating cardiac conduction development, which may provide insight into congenital arrhythmia syndromes. Wolff-Parkinson-White (WPW) syndrome affects 1 in 500 people and is characterized by accessory atrioventricular pathways in the heart which bypass the normal conduction system and can result in ventricular preexcitation, palpitations, and sudden cardiac death. Although WPW has been well described clinically, the developmental mechanisms behind the formation of this functional ectopic myocardial tissue are poorly understood. We utilize a novel murine model to better understand this disorder. In addition, we utilize reprogramming approaches to convert mature cardiomyocytes into conduction-like cells, which may ultimately be useful in regenerative approaches such as the development of a biologic pacemaker.

Areas of Clinical Interest

Fingerprint

Dive into the research topics where Stacey Rentschler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 6 Similar Profiles

Network

Recent external collaboration on country level. Dive into details by clicking on the dots.
If you made any changes in Pure these will be visible here soon.