Stacey Rentschler

Assistant Professor of Medicine, Assistant Professor of Developmental Biology, Assistant Professor of Biomedical Engineering

  • 1269 Citations
19972019
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Personal profile

Research interests

The cardiac conduction system generates and propagates electrical impulses within the heart, and cells of the conduction network arise from lineage specification of cardiomyocyte progenitors. We are seeking to understand the mechanisms regulating cardiac conduction development, which may provide insight into congenital arrhythmia syndromes. Wolff-Parkinson-White (WPW) syndrome affects 1 in 500 people and is characterized by accessory atrioventricular pathways in the heart which bypass the normal conduction system and can result in ventricular preexcitation, palpitations, and sudden cardiac death. Although WPW has been well described clinically, the developmental mechanisms behind the formation of this functional ectopic myocardial tissue are poorly understood. We utilize a novel murine model to better understand this disorder. In addition, we utilize reprogramming approaches to convert mature cardiomyocytes into conduction-like cells, which may ultimately be useful in regenerative approaches such as the development of a biologic pacemaker.

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  • 7 Similar Profiles
Cardiac Myocytes Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Electrophysiology Medicine & Life Sciences
Cardiac Arrhythmias Medicine & Life Sciences
Myocardium Medicine & Life Sciences
Heart Diseases Medicine & Life Sciences
Gene Expression Medicine & Life Sciences
Neuregulin-1 Medicine & Life Sciences

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Research Output 1997 2019

  • 1269 Citations
  • 23 Article
  • 4 Review article
  • 2 Editorial
  • 1 Conference contribution

Transcriptional and Epigenetic Regulation of Cardiac Electrophysiology

Jimenez, J. & Rentschler, S., Jan 1 2019, In : Pediatric Cardiology.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Cardiac Electrophysiology
Epigenomics
Cardiac Arrhythmias
Brugada Syndrome
Gene Expression
1 Citation (Scopus)

Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles

Li, G., Khandekar, A., Yin, T., Hicks, S. C., Guo, Q., Takahashi, K., Lipovsky, C. E., Brumback, B. D., Rao, P. K., Weinheimer, C. & Rentschler, S., Oct 1 2018, In : Journal of Molecular and Cellular Cardiology. 123, p. 92-107 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Heart Ventricles
Brugada Syndrome
Cardiac Arrhythmias
Cardiac Myocytes
Genes
2 Citations (Scopus)

Fractionated electrograms with ST-segment elevation recorded from the human right ventricular outflow tract

Vigmond, E. J., Efimov, I. R., Rentschler, S., Coronel, R. & Boukens, B. J., Nov 1 2017, In : HeartRhythm Case Reports. 3, 11, p. 546-550 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Brugada Syndrome
5 Citations (Scopus)

Transient notch activation induces long-term gene expression changes leading to sick sinus syndrome in mice

Qiao, Y., Lipovsky, C., Hicks, S., Bhatnagar, S., Li, G., Khandekar, A., Guzy, R., Woo, K. V., Nichols, C., Efimov, I. R. & Rentschler, S., Aug 1 2017, In : Circulation research. 121, 5, p. 549-563 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Sick Sinus Syndrome
Ion Channels
Cardiac Arrhythmias
Sinoatrial Node
Electrophysiology
20 Citations (Scopus)

Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials

Kang, C., Qiao, Y., Li, G., Baechle, K., Camelliti, P., Rentschler, S. & Efimov, I. R., Jun 30 2016, In : Scientific reports. 6, 28798.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Voltage-Sensitive Dye Imaging
Optogenetics
Therapeutics
Sinoatrial Node
Electrophysiology