• 1204 Citations
20052019

Research output per year

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Personal profile

Research interests

The actin cytoskeleton is an intricate polymer system that can be assembled into many different structures, ranging from stable stress fibers that locally support cell adhesion, to the extensive and dynamic branched network at the leading edge that drives cell migration. However, a question that keeps intriguing the field is how this plethora of structures, each with their own particular turnover rates and physical properties, can be assembled in the same cytosol from the same basic building blocks, i.e. actin filaments. In other words, what determines the fate of an actin filament? In the Jansen lab, we are using a combination of genetics, biomimetic systems, cell imaging, multi-color in vitro TIRF microscopy and single molecule techniques to investigate how two important, but heavily understudied families of actin-binding proteins, the Tropomyosins and the Coronins, play a role as regulatory hubs that generate different actin filament populations that are optimally suited to mediate intracellular trafficking, cell migration, cytokinesis or cell adhesion. For more information on past and current projects, go to https://silviajansen.wixsite.com/jansen-lab.

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Research Output

  • 1204 Citations
  • 18 Article
  • 2 Review article

Scaling behaviour in steady-state contracting actomyosin networks

Malik-Garbi, M., Ierushalmi, N., Jansen, S., Abu-Shah, E., Goode, B. L., Mogilner, A. & Keren, K., May 1 2019, In : Nature Physics. 15, 5, p. 509-516 8 p.

Research output: Contribution to journalArticle

  • 8 Scopus citations

    Tropomyosin isoforms differentially tune actin filament length and disassembly

    Jansen, S. & Goode, B. L., 2019, In : Molecular biology of the cell. 30, 5, p. 671-679 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 10 Scopus citations

    TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover

    Chin, S. M., Jansen, S. & Goode, B. L., Apr 24 2016, In : Journal of Molecular Biology. 428, 8, p. 1604-1616 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 17 Scopus citations

    Combinatorial genetic analysis of a network of actin disassembly-promoting factors

    Ydenberg, C. A., Johnston, A., Weinstein, J., Bellavance, D., Jansen, S. & Goode, B. L., Jul 1 2015, In : Cytoskeleton. 72, 7, p. 349-361 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 11 Scopus citations

    Coronin Enhances Actin Filament Severing by Recruiting Cofilin to Filament Sides and Altering F-Actin Conformation

    Mikati, M. A., Breitsprecher, D., Jansen, S., Reisler, E. & Goode, B. L., Sep 25 2015, In : Journal of Molecular Biology. 427, 19, p. 3137-3147 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 33 Scopus citations