• Source: Scopus
20052019

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The actin cytoskeleton is an intricate polymer system that can be assembled into many different structures, ranging from stable stress fibers that locally support cell adhesion, to the extensive and dynamic branched network at the leading edge that drives cell migration. However, a question that keeps intriguing the field is how this plethora of structures, each with their own particular turnover rates and physical properties, can be assembled in the same cytosol from the same basic building blocks, i.e. actin filaments. In other words, what determines the fate of an actin filament?

In the Jansen lab, we are using a combination of genetics, biomimetic systems, cell imaging, multi-color in vitro TIRF microscopy and single molecule techniques to investigate how two important, but heavily understudied families of actin-binding proteins, the Tropomyosins and the Coronins, play a role as regulatory hubs that generate different actin filament populations that are optimally suited to mediate intracellular trafficking, cell migration, cytokinesis or cell adhesion. For more information on past and current projects, go to https://silviajansen.wixsite.com/jansen-lab.

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