Shin-Ichiro Imai

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PhD/MSTP Students

23410

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Research activity per year

Research interests

My lab's major interest is to understand the systemic regulatory network for the control of aging and longevity in mammals, focusing on the roles of NAD-dependent mammalian sirtuins and NAD biosynthesis pathways. We are also trying to translate our findings to humans and develop preventive/therapeutic anti-aging interventions.

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Available to Mentor:

PhD/MSTP Students

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69 Article
25 Review article
3 Chapter
2 Editorial
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NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control
Imai, S. I., Dec 2025, In: npj Aging. 11, 1, 4.
Research output: Contribution to journal › Review article › peer-review

Open Access
1 Scopus citations
PPDPF: Preventing kidney disease through NAD⁺ regulation
Imai, S. I. & Imai, S. I., Mar 21 2025, In: Science Advances. 11, 12, eadw6815.
Research output: Contribution to journal › Article › peer-review
Protocol to study inter-tissue communication between the hypothalamus and white adipose tissue and lifespan using a chemogenetic approach in aged mice
Tokizane, K. & Imai, S. I., Mar 21 2025, In: STAR Protocols. 6, 1, 103551.
Research output: Contribution to journal › Article › peer-review

Open Access
Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)
Unno, J., Mills, K. F., Ogura, T., Nishimura, M. & Imai, S. I., Dec 2024, In: npj Aging. 10, 1, 2.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Scopus citations
DMH^Ppp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication
Tokizane, K., Brace, C. S. & Imai, S. I., Feb 6 2024, In: Cell metabolism. 36, 2, p. 377-392.e11
Research output: Contribution to journal › Article › peer-review

Open Access
14 Scopus citations

Shin-Ichiro Imai

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Research interests

Available to Mentor:

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Collaborations and top research areas from the last five years

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NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

PPDPF: Preventing kidney disease through NAD⁺ regulation

Protocol to study inter-tissue communication between the hypothalamus and white adipose tissue and lifespan using a chemogenetic approach in aged mice

Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)

DMH^Ppp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication

Shin-Ichiro Imai

Personal profile

Research interests

Available to Mentor:

Fingerprint

Collaborations and top research areas from the last five years

Research output

NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

PPDPF: Preventing kidney disease through NAD+ regulation

Protocol to study inter-tissue communication between the hypothalamus and white adipose tissue and lifespan using a chemogenetic approach in aged mice

Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)

DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication

PPDPF: Preventing kidney disease through NAD⁺ regulation

DMH^Ppp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication