Research output per year
Research output per year
Personal profile
Research interests
My lab's major interest is to understand the systemic regulatory network for the control of aging and longevity in mammals, focusing on the roles of NAD-dependent mammalian sirtuins and NAD biosynthesis pathways. We are also trying to translate our findings to humans and develop preventive/therapeutic anti-aging interventions.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)
Unno, J., Mills, K. F., Ogura, T., Nishimura, M. & Imai, S. I., Dec 2024, In: npj Aging. 10, 1, 2.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication
Tokizane, K., Brace, C. S. & Imai, S. I., Feb 6 2024, In: Cell metabolism. 36, 2, p. 377-392.e11Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Inter-organ communication is a critical machinery to regulate metabolism and aging
Tokizane, K. & Imai, S. I., 2024, (Accepted/In press) In: Trends in Endocrinology and Metabolism.Research output: Contribution to journal › Review article › peer-review
Open Access -
Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study
Akasaka, H., Nakagami, H., Sugimoto, K., Yasunobe, Y., Minami, T., Fujimoto, T., Yamamoto, K., Hara, C., Shiraki, A., Nishida, K., Asano, K., Kanou, M., Yamana, K., Imai, S. I. & Rakugi, H., Jan 2023, In: Geriatrics and Gerontology International. 23, 1, p. 38-43 6 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus
Johnson, S., Yoshioka, K., Brace, C. S. & Imai, S. I., Dec 2023, In: npj Aging. 9, 1, 1.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations