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Shin-Ichiro Imai

Professor of Developmental Biology, Professor of Medicine

    • 15396 Citations
    1992 …2020

    Research output per year

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    Personal profile

    Research interests

    My lab's major interest is to understand the systemic regulatory network for the control of aging and longevity in mammals, focusing on the roles of NAD-dependent mammalian sirtuins and NAD biosynthesis pathways. We are also trying to translate our findings to humans and develop preventive/therapeutic anti-aging interventions.

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    Research Output

    Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

    Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., Okano, H., Nabeshima, Y. I., Imai, S. I., Yasui, M., Tsubota, K. & Itoh, H., Jan 1 2020, In : Endocrine Journal. 67, 2, p. 153-160 8 p.

    Research output: Contribution to journal › Article

    Open Access
    • 8 Scopus citations

    SS-31 and NMN: Two paths to improve metabolism and function in aged hearts

    Whitson, J. A., Bitto, A., Zhang, H., Sweetwyne, M. T., Coig, R., Bhayana, S., Shankland, E. G., Wang, L., Bammler, T. K., Mills, K. F., Imai, S. I., Conley, K. E., Marcinek, D. J. & Rabinovitch, P. S., 2020, (Accepted/In press) In : Aging Cell.

    Research output: Contribution to journal › Article

    Open Access

    • Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter (Nature Metabolism, (2019), 1, 1, (47-57), 10.1038/s42255-018-0009-4)

    Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E. & Imai, S. I., Jul 1 2019, In : Nature Metabolism. 1, 7, 1 p.

    Research output: Contribution to journal › Comment/debate

    • Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice

    Yoshida, M., Satoh, A., Lin, J. B., Mills, K. F., Sasaki, Y., Rensing, N., Wong, M., Apte, R. S. & Imai, S. I., Aug 6 2019, In : Cell metabolism. 30, 2, p. 329-342.e5

    Research output: Contribution to journal › Article

    • 42 Scopus citations

    Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

    Grozio, A., Mills, K., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Sasaki, Y., Migaud, M. & Imai, S. I., Jul 1 2019, In : Nature Metabolism. 1, 7, p. 662-665 4 p.

    Research output: Contribution to journal › Letter

    Open Access
    1 Scopus citations