Research output per year
Research output per year
Personal profile
Research interests
My lab's major interest is to understand the systemic regulatory network for the control of aging and longevity in mammals, focusing on the roles of NAD-dependent mammalian sirtuins and NAD biosynthesis pathways. We are also trying to translate our findings to humans and develop preventive/therapeutic anti-aging interventions.
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Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment
Whitson, J. A., Johnson, R., Wang, L., Bammler, T. K., Imai, S. I., Zhang, H., Fredrickson, J., Latorre-Esteves, E., Bitto, A., MacCoss, M. J. & Rabinovitch, P. S., Jun 2022, In: GeroScience. 44, 3, p. 1621-1639 19 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
SIRT1 mediates hypoxic postconditioning- and resveratrol-induced protection against functional connectivity deficits after subarachnoid hemorrhage
Clarke, J. V., Brier, L. M., Rahn, R. M., Diwan, D., Yuan, J. Y., Bice, A. R., Imai, S. I., Vellimana, A. K., Culver, J. P. & Zipfel, G. J., Jul 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 7, p. 1210-1223 14 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
Ito, N., Takatsu, A., Ito, H., Koike, Y., Yoshioka, K., Kamei, Y. & Imai, S. I., Jul 26 2022, In: Cell Reports. 40, 4, 111131.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Friends and foes: Extracellular vesicles in aging and rejuvenation
Lananna, B. V. & Imai, S. I., Oct 2021, In: FASEB BioAdvances. 3, 10, p. 787-801 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I. & Klein, S., Jun 11 2021, In: Science. 372, 6547, p. 1224-1229 6 p.Research output: Contribution to journal › Article › peer-review
91 Scopus citations