• 15396 Citations
1992 …2020

Research output per year

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Personal profile

Research interests

My lab's major interest is to understand the systemic regulatory network for the control of aging and longevity in mammals, focusing on the roles of NAD-dependent mammalian sirtuins and NAD biosynthesis pathways. We are also trying to translate our findings to humans and develop preventive/therapeutic anti-aging interventions.

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Research Output

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., Okano, H., Nabeshima, Y. I., Imai, S. I., Yasui, M., Tsubota, K. & Itoh, H., Jan 1 2020, In : Endocrine Journal. 67, 2, p. 153-160 8 p.

Research output: Contribution to journalArticle

Open Access
  • 8 Scopus citations

    SS-31 and NMN: Two paths to improve metabolism and function in aged hearts

    Whitson, J. A., Bitto, A., Zhang, H., Sweetwyne, M. T., Coig, R., Bhayana, S., Shankland, E. G., Wang, L., Bammler, T. K., Mills, K. F., Imai, S. I., Conley, K. E., Marcinek, D. J. & Rabinovitch, P. S., 2020, (Accepted/In press) In : Aging Cell.

    Research output: Contribution to journalArticle

    Open Access
  • Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter (Nature Metabolism, (2019), 1, 1, (47-57), 10.1038/s42255-018-0009-4)

    Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E. & Imai, S. I., Jul 1 2019, In : Nature Metabolism. 1, 7, 1 p.

    Research output: Contribution to journalComment/debate

  • Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice

    Yoshida, M., Satoh, A., Lin, J. B., Mills, K. F., Sasaki, Y., Rensing, N., Wong, M., Apte, R. S. & Imai, S. I., Aug 6 2019, In : Cell metabolism. 30, 2, p. 329-342.e5

    Research output: Contribution to journalArticle

  • 42 Scopus citations

    Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

    Grozio, A., Mills, K., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Sasaki, Y., Migaud, M. & Imai, S. I., Jul 1 2019, In : Nature Metabolism. 1, 7, p. 662-665 4 p.

    Research output: Contribution to journalLetter

    Open Access
    1 Scopus citations