• 12004 Citations
1990 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

The development of diffusion tensor imaging (DTI) biomarker of white matter injury validated using mouse models of central nervous system (CNS) disorders has been the primary research goal of Song lab for the past decade. During this period, Song group has demonstrated that DTI derived axial and radial diffusivity accurately reflects mouse CNS white matter injury. The approach has been translated to patients of multiple sclerosis (MS) and cervical spinal cord injury patients. To improve the sensitivity and specificity of diffusion MRI biomarker of CNS injury, a novel diffusion MRI method, diffusion basis spectrum imaging (DBSI), has recently been developed to resolve the intravoxel partial volume effect to correctly estimate axial and radial diffusivity of axonal fibers in the presence of inflammation and/or tissue loss. One of the crucial utilities of DBSI is its ability to detect and quantify the extent of increased cellularity and edema associated with CNS inflammation. In addition to the development of the biomarker of CNS injury, Song lab has also reported the first successful diffusion fMRI to non-invasively detect the activation of mouse optic nerve.

Fingerprint Dive into the research topics where Sheng-Kwei Song is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 29 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

  • 12004 Citations
  • 120 Article
  • 6 Conference contribution
  • 3 Review article

Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions

Ye, Z., George, A., Wu, A. T., Niu, X., Lin, J., Adusumilli, G., Naismith, R. T., Cross, A. H., Sun, P. & Song, S. K., May 1 2020, In : Annals of Clinical and Translational Neurology. 7, 5, p. 695-706 12 p.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    Diffusion basis spectrum imaging provides insights into MS pathology

    Sun, P., George, A., Perantie, D. C., Trinkaus, K., Ye, Z., Naismith, R. T., Song, S. K. & Cross, A. H., Mar 1 2020, In : Neurology(R) neuroimmunology & neuroinflammation. 7, 2

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging

    Samara, A., Murphy, T., Strain, J., Rutlin, J., Sun, P., Neyman, O., Sreevalsan, N., Shimony, J. S., Ances, B. M., Song, S. K., Hershey, T. & Eisenstein, S. A., Jan 14 2020, In : Frontiers in Human Neuroscience. 13, 464.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

    Human Tumor Atlas Network, Apr 16 2020, In : Cell. 181, 2, p. 236-249 14 p.

    Research output: Contribution to journalReview article

    Open Access
  • 5 Scopus citations

    Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

    Shin, J., Yan, Y., Bai, W., Xue, Y., Gamble, P., Tian, L., Kandela, I., Haney, C. R., Spees, W., Lee, Y., Choi, M., Ko, J., Ryu, H., Chang, J. K., Pezhouh, M., Kang, S. K., Won, S. M., Yu, K. J., Zhao, J., Lee, Y. K. & 5 others, MacEwan, M. R., Song, S. K., Huang, Y., Ray, W. Z. & Rogers, J. A., Jan 1 2019, In : Nature Biomedical Engineering. 3, 1, p. 37-46 10 p.

    Research output: Contribution to journalArticle

  • 47 Scopus citations