Personal profile
Research interests
My group is interested in understanding how age-related changes in the stromal compartment impact tumorigenesis. To study this we utilize basic cell culture systems and have created a conditional mouse in which we can induce old fibroblasts in young animals and determine how this impacts tumor rates in the skin and breast. Ultimately we intend to use this mouse model to determine the mechanism by which old stromal cells promote tumorigenesis.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Cellular senescence in human liver under normal aging and cancer
Karpova, A., Li, X., Peng, C. W., Gallant, K. L., Rapp, D. R., Alligood, D. M., Houston, A. J., Park, A., Targino da Costa, A. L. N., Chou, W. H., Iglesia, M., Herndon, J. M., Byrnes, K., Naser Al Deen, N., Lal, P., Fang, X., Jayasinghe, R. G., Blatnik, J., Hawkins, W. & Sanford, D. & 19 others, , Feb 11 2026, In: Cell Genomics. 6, 2, 101133.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Chemotherapy-induced adipo-lineage cell senescence drives bone loss
Raut, G. K., Malachowski, T., Melam, A., Ramalho-Oliveira, R., Holt, T., Luo, X., Yao, Z., Faget, D. V., Ren, Q., DeNardo, D. G. & Stewart, S. A., Dec 2026, In: Nature communications. 17, 1, 1042.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Inflammaging in aged tissues drives remodeling of the CD8+T cell compartment
Shchukina, I., Rodriguez-Hernandez, C. J., Ruiz, H. S., Kleverov, M., Mintz, R. L., Mineura, K., Gunawardana, S. C., Hsiung, S., Bhattarai, B., Vachova, V., Kossl, J., Mogilenko, D. A., Field, R. L., Nguyen, T. H., Alayo, Q. A., Huckstep, C. G., Vander Wielen, B., Brestoff, J. R., Stewart, S. A. & Piston, D. W. & 4 others, , May 26 2026, In: Cell Reports. 45, 5, 117303.Research output: Contribution to journal › Article › peer-review
Open Access -
Age-related mesenchymal stromal cell senescence is associated with progression from MGUS to multiple myeloma
Plakhova, N., Panagopoulos, V., Cantley, M. D., Trainor, L. J., Hewett, D. R., Clark, K. C., Gardiner, J., Yong, A., Lee, C., Horvath, N., Croucher, P. I., Cakouros, D., Stewart, S. A., Gronthos, S., Zannettino, A. C. W., Mrozik, K. M. & Vandyke, K., Jun 2025, In: Leukemia. 39, 6, p. 1464-1475 12 p., 606.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan
Chen, S., Liu, R., Mo, C. K., Wendl, M. C., Houston, A., Lal, P., Zhao, Y., Caravan, W., Shinkle, A. T., Abedin-Do, A., Naser Al Deen, N., Sato, K., Li, X., Targino da Costa, A. L. N., Li, Y., Karpova, A., Herndon, J. M., Artyomov, M. N., Rubin, J. B. & Jain, S. & 4 others, , May 2025, In: Nature Genetics. 57, 5, p. 1213-1227 15 p., 1396.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Scopus citations