• 7934 Citations
1992 …2020

Research output per year

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Personal profile

Research interests

My group is interested in understanding how age-related changes in the stromal compartment impact tumorigenesis. To study this we utilize basic cell culture systems and have created a conditional mouse in which we can induce old fibroblasts in young animals and determine how this impacts tumor rates in the skin and breast. Ultimately we intend to use this mouse model to determine the mechanism by which old stromal cells promote tumorigenesis.

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Research Output

  • 7934 Citations
  • 52 Article
  • 8 Review article
  • 2 Chapter
  • 1 Comment/debate

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., Hynes, R. O., Jain, R. K., Janowitz, T., Jorgensen, C., Kimmelman, A. C., Kolonin, M. G., Maki, R. G., Powers, R. S., Puré, E., Ramirez, D. C. & 9 others, Scherz-Shouval, R., Sherman, M. H., Stewart, S., Tlsty, T. D., Tuveson, D. A., Watt, F. M., Weaver, V., Weeraratna, A. T. & Werb, Z., Mar 1 2020, In : Nature Reviews Cancer. 20, 3, p. 174-186 13 p.

Research output: Contribution to journalReview article

Open Access
  • 68 Scopus citations

    Therapy-induced senescence drives bone loss

    Yao, Z., Murali, B., Ren, Q., Luo, X., Faget, D. V., Cole, T., Ricci, B., Thotala, D., Monahan, J., Van Deursen, J. M., Baker, D., Faccio, R., Schwarz, J. K. & Stewart, S. A., Mar 1 2020, In : Cancer research. 80, 5, p. 1171-1182 12 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Unmasking senescence: context-dependent effects of SASP in cancer

    Faget, D. V., Ren, Q. & Stewart, S. A., Aug 1 2019, In : Nature Reviews Cancer. 19, 8, p. 439-453 15 p.

    Research output: Contribution to journalReview article

  • 43 Scopus citations

    c-Myb and C/EBPβ regulate OPN and other senescenceassociated secretory phenotype factors

    Flanagan, K. C., Alspach, E., Pazolli, E., Parajuli, S., Ren, Q., Arthur, L. L., Tapia, R. & Stewart, S. A., Jan 1 2018, In : Oncotarget. 9, 1, p. 21-36 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    Increasing nerve autograft length increases senescence and reduces regeneration

    Hoben, G. M., Ee, X., Schellhardt, L., Yan, Y., Hunter, D. A., Moore, A. M., Snyder-Warwick, A. K., Stewart, S., Mackinnon, S. E. & Wood, M. D., Jan 1 2018, In : Plastic and reconstructive surgery. 142, 4, p. 952-961 10 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations