Research output per year
Research output per year
Personal profile
Research interests
My group is interested in understanding how age-related changes in the stromal compartment impact tumorigenesis. To study this we utilize basic cell culture systems and have created a conditional mouse in which we can induce old fibroblasts in young animals and determine how this impacts tumor rates in the skin and breast. Ultimately we intend to use this mouse model to determine the mechanism by which old stromal cells promote tumorigenesis.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer
Belle, J. I., Sen, D., Baer, J. M., Liu, X., Lander, V. E., Ye, J., Sells, B. E., Knolhoff, B. L., Faiz, A., Kang, L. I., Qian, G., Fields, R. C., Ding, L., Kim, H., Provenzano, P. P., Stewart, S. A. & Denardo, D. G., Jul 1 2024, In: Cancer discovery. 14, 7, p. 1324-1355 32 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression
Ye, J., Baer, J. M., Faget, D. V., Morikis, V. A., Ren, Q., Melam, A., Delgado, A. P., Luo, X., Mullick Bagchi, S., Belle, J. I., Campos, E., Friedman, M., Veis, D. J., Knudsen, E. S., Witkiewicz, A. K., Powers, S., Longmore, G. D., Denardo, D. G. & Stewart, S. A., Jul 1 2024, In: Cancer discovery. 14, 7, p. 1302-1323 22 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration
Hwang, P. Y., Mathur, J., Cao, Y., Almeida, J., Ye, J., Morikis, V., Cornish, D., Clarke, M., Stewart-Wigglesworth, S., Pathak, A. & Longmore, G. D., Jan 9 2023, In: Developmental cell. 58, 1, p. 34-50.e9Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy
Faget, D. V., Luo, X., Inkman, M. J., Ren, Q., Su, X., Ding, K., Waters, M. R., Raut, G. K., Pandey, G., Dodhiawala, P. B., Ramalho-Oliveira, R., Ye, J., Cole, T., Murali, B., Zheleznyak, A., Shokeen, M., Weiss, K. R., Monahan, J. B., Deselm, C. J. & Lee, A. V. & 5 others, , Jun 1 2023, In: Cancer discovery. 13, 6, p. 1454-1477 24 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Gene expression predicts dormant metastatic breast cancer cell phenotype
Ren, Q., Khoo, W. H., Corr, A. P., Phan, T. G., Croucher, P. I. & Stewart, S. A., Dec 2022, In: Breast Cancer Research. 24, 1, 10.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations