Research output per year
Research output per year
Personal profile
Research interests
Regulation of adaptive and innate immunity by actin-binding proteins, currently focusing on the role of the bundling protein L-plastin. Mice deficient for L-plastin exhibit defects in T and B cell chemotaxis and activation due to failures of cellular polarization and maintenance of cell contacts. I am also developing a research interested into pulmonary immunity and the immune response in pneumococcal pneumonia.
Clinical interests
Pediatric infections
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis
Lin, X., Krishnamoorthy, P., Walker, E. C., Joshi, H. & Morley, S. C., 2023, In: Frontiers in Cell and Developmental Biology. 11, 1020091.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood
Borcherding, N., Jia, W., Giwa, R., Field, R. L., Moley, J. R., Kopecky, B. J., Chan, M. M., Yang, B. Q., Sabio, J. M., Walker, E. C., Osorio, O., Bredemeyer, A. L., Pietka, T., Alexander-Brett, J., Morley, S. C., Artyomov, M. N., Abumrad, N. A., Schilling, J., Lavine, K., Crewe, C., & 1 others, Oct 4 2022, In: Cell metabolism. 34, 10, p. 1499-1513.e8Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Efficient T Cell Migration and Activation Require L-Plastin
Joshi, H. & Morley, S. C., Jun 29 2022, In: Frontiers in immunology. 13, 916137.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay
Seth, A., Mittal, E., Luan, J., Kolla, S., Mazer, M., Joshi, H., Gupta, R., Rathi, P., Wang, Z., Morrissey, J. J., Ernst, J. D., Portal-Celhay, C., Morley, S. C., Philips, J. A. & Singamaneni, S., Aug 22 2022, In: Cell Reports Methods. 2, 8, 100267.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis
Joshi, H., Almgren-Bell, A., Anaya, E. P., Todd, E. M., Van Dyken, S. J., Seth, A., McIntire, K. M., Singamaneni, S., Sutterwala, F. & Morley, S. C., Mar 15 2022, In: Cell Reports. 38, 11, 110507.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations