Research output per year
Research output per year
Personal profile
Research interests
Regulation of adaptive and innate immunity by actin-binding proteins, currently focusing on the role of the bundling protein L-plastin. Mice deficient for L-plastin exhibit defects in T and B cell chemotaxis and activation due to failures of cellular polarization and maintenance of cell contacts. I am also developing a research interested into pulmonary immunity and the immune response in pneumococcal pneumonia.
Clinical interests
Pediatric infections
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L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis
Joshi, H., Almgren-Bell, A., Anaya, E. P., Todd, E. M., Van Dyken, S. J., Seth, A., McIntire, K. M., Singamaneni, S., Sutterwala, F. & Morley, S. C., Mar 15 2022, In: Cell Reports. 38, 11, 110507.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel mouse model reveals that serine phosphorylation of l-plastin is essential for effective splenic clearance of pneumococcus
Anaya, E. P., Lin, X., Todd, E. M., Szasz, T. P. & Morley, S. C., May 1 2021, In: Journal of Immunology. 206, 9, p. 2135-2145 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Recovery from COVID-19 in a Child with Chronic Granulomatous Disease and T Cell Lymphopenia
Mantravadi, V., Nguyen, S. T., Morley, S. C., Bednarski, J. J., Kitcharoensakkul, M. & Cooper, M. A., Jan 2021, In: Journal of Clinical Immunology. 41, 1, p. 23-25 3 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction
Chellaiah, M. A., Moorer, M. C., Majumdar, S., Aljohani, H., Morley, S. C., Yingling, V. & Stains, J. P., Dec 1 2020, In: Bone Research. 8, 1, 3.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin
Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., Cody, M. J., Morley, S. C., Nagalla, S., Weyrich, A. S., Rowley, J. W., O'Connell, R. M., Rondina, M. T., Campbell, R. A. & Bray, P. F., Oct 8 2020, In: Blood. 136, 15, p. 1760-1772 13 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations