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Sharon Cresci

Associate Professor of Medicine, Associate Professor of Genetics

    • 2810 Citations
    1992 …2020

    Research output per year

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    Personal profile

    Research interests

    My laboratory is engaged in translational research focused on investigating genetic and pharmacogenetic associations with cardiovascular disease, with a particular interest in diabetic cardiovascular disease. Ongoing projects in my laboratory include 1) comprehensively investigating the genetic and pharmacogenetic associations of PPAR-pathway variants, using a custom PPAR-pathway targeted-genotyping 3K array, in a population with type 2 DM and coronary artery disease that has been extensively phenotyped (BARI 2D cohort); 2) assessing the predictive impact of genetic variants in the context of modern post-ACS therapy in a cohort of 4,500 patients with acute myocardial infarction (TRIUMPH cohort).

    Areas of Clinical Interest

    Transthoracic, transesophageal and stress echocardiograms

    Keywords

    • COVID-19

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    Research Output

    Association of factor v leiden with subsequent atherothrombotic events: A GENIUS-CHD study of individual participant data

    Mahmoodi, B. K., Tragante, V., Kleber, M. E., Holmes, M. V., Schmidt, A. F., McCubrey, R. O., Howe, L. J., Direk, K., Allayee, H., Baranova, E. V., Braund, P. S., Delgado, G. E., Eriksson, N., Gijsberts, C. M., Gong, Y., Hartiala, J., Heydarpour, M., Pasterkamp, G., Kotti, S., Kuukasjärvi, P. & 64 others, Lenzini, P. A., Levin, D., Lyytikäinen, L. P., Muehlschlegel, J. D., Nelson, C. P., Nikus, K., Pilbrow, A. P., Wilson Tang, W. H., Van Der Laan, S. W., Van Setten, J., Vilmundarson, R. O., Deanfield, J., Deloukas, P., Dudbridge, F., James, S., Mordi, I. R., Teren, A., Bergmeijer, T. O., Body, S. C., Bots, M., Burkhardt, R., Cooper-Dehoff, R. M., Cresci, S., Danchin, N., Doughty, R. N., Grobbee, D. E., Hagström, E., Hazen, S. L., Held, C., Hoefer, I. E., Hovingh, G. K., Johnson, J. A., Kaczor, M. P., Kähönen, M., Klungel, O. H., Laurikka, J. O., Lehtimäki, T., Maitland-Van Der Zee, A. H., McPherson, R., Palmer, C. N., Kraaijeveld, A. O., Pepine, C. J., Sanak, M., Sattar, N., Scholz, M., Simon, T., Spertus, J. A., Stewart, A. F. R., Szczeklik, W., Thiery, J., Visseren, F. L. J., Waltenberger, J., Richards, A. M., Lang, C. C., Cameron, V. A., Åkerblom, A., Pare, G., März, W., Samani, N. J., Hingorani, A. D., Ten Berg, J. M., Wallentin, L., Asselbergs, F. W. & Patel, R. S., Aug 11 2020, In : Circulation. 142, 6, p. 546-555 10 p.

    Research output: Contribution to journal › Article

    • PPARA polymorphism influences the cardiovascular benefit of fenofibrate in type 2 diabetes: Findings from accord-lipid

    Morieri, M. L., Shah, H. S., Sjaarda, J., Lenzini, P. A., Campbell, H., Motsinger-Reif, A. A., Gao, H., Lovato, L., Prudente, S., Pandolfi, A., Pezzolesi, M. G., Sigal, R. J., Paré, G., Marcovina, S. M., Rotroff, D. M., Patorno, E., Mercuri, L., Trischitta, V., Chew, E. Y., Kraft, P. & 7 others, Buse, J. B., Wagner, M. J., Cresci, S., Gerstein, H. C., Ginsberg, H. N., Mychaleckyj, J. C. & Doria, A., Apr 1 2020, In : Diabetes. 69, 4, p. 771-783 13 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    A genetic locus on chromosome 2q24 predicting peripheral neuropathy risk in type 2 diabetes: Results from the ACCORD and BARI 2D studies

    Tang, Y., Lenzini, P. A., Pop-Busui, R., Ray, P. R., Campbell, H., Perkins, B. A., Callaghan, B., Wagner, M. J., Motsinger-Reif, A. A., Buse, J. B., Price, T. J., Mychaleckyj, J. C., Cresci, S., Shah, H. & Doria, A., Aug 1 2019, In : Diabetes. 68, 8, p. 1649-1662 14 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Association of chromosome 9p21 with subsequent coronary heart disease events: A GENIUS-CHD study of individual participant data

    CARDIoGRAMPlusC4D Consortium, 2019, In : Circulation: Genomic and Precision Medicine. 12, 4, p. 161-172 12 p.

    Research output: Contribution to journal › Article

    Open Access
    • 6 Scopus citations

    Heart Failure in the Era of Precision Medicine: A Scientific Statement from the American Heart Association

    Cresci, S., Pereira, N. L., Ahmad, F., Byku, M., De Las Fuentes, L., Lanfear, D. E., Reilly, C. M., Owens, A. T. & Wolf, M. J., Oct 1 2019, In : Circulation: Genomic and Precision Medicine. 12, 10, p. 458-485 28 p., e000058.

    Research output: Contribution to journal › Review article

    • 7 Scopus citations