Shabaana Abdul Khader

Professor of Molecular Microbiology, Professor of Pathology and Immunology, Professor of Pathology and Immunology

    • 6511 Citations

    Research output per year

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    Personal profile

    Research interests

    Approximately one-third of the world’s population is infected with Mycobacterium tuberculosis (Mtb), the pathogen that causes the infectious disease tuberculosis (TB). Every year almost 8.6 million new cases of this infectious disease are recorded, resulting in around 1.3 million people dying of TB, equaling one death every 24 seconds. It is estimated that 10% of infected individuals will progress to exhibit clinical disease, a form called pulmonary TB (PTB). The risk of developing TB is 10-20 times greater in people infected with HIV, resulting in TB being the biggest killer in HIV/AIDS patients. Global efforts to combat TB are hampered by the emergence of extremely drug-resistant (XDR) and multi drug-resistant (MDR) strains of Mtb and the variable efficacy of the currently available vaccine, M.bovis BCG. Unfortunately, the immune mechanisms that govern progression from latent to PTB remain poorly defined, preventing rational design of treatments or vaccines that may promote the immune control of TB. In addition, although significant progress has been made in identifying protective Mtb antigen candidates, our poor understanding of how immune responses mediate protection in the lung remains a major hurdle to successful vaccine design. The major goal of the Khader Lab is to define the basic requirements for induction of protective immunity in the lung that will result in improved vaccines, therapies and treatment for TB. Work in the Khader Lab is focused on three major areas of research interests: 1. Targeting the cytokine Interleukin-17 to generate vaccine responses against TB 2. Studying the role of inducible Bronchus Associated Lymphoid tissue (iBALT) in TB 3. Host pathogen interactions of non-tuberculous mycobacterial infections

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    Research Output

    Chronic Immune Activation in TB/HIV Co-infection

    Sharan, R., Bucşan, A. N., Ganatra, S., Paiardini, M., Mohan, M., Mehra, S., Khader, S. A. & Kaushal, D., Jan 1 2020, (Accepted/In press) In : Trends in Microbiology.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport

    Li, L. X., Hole, C. R., Rangel-Moreno, J., Abdul Khader, S. & Doering, T. L., Jul 21 2020, In : Infection and immunity. 88, 8

    Research output: Contribution to journalArticle

  • Erratum: Chronic Immune Activation in TB/HIV Co-infection: (Trends in Microbiology 28, XXX–XXX; 2020) (Trends in Microbiology, (S0966842X2030086X), (10.1016/j.tim.2020.03.015))

    Sharan, R., Bucşan, A. N., Ganatra, S., Paiardini, M., Mohan, M., Mehra, S., Khader, S. A. & Kaushal, D., Jan 1 2020, (Accepted/In press) In : Trends in Microbiology.

    Research output: Contribution to journalComment/debate

  • Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Mycobacterium tuberculosis Expressed Determinants

    Dunlap, M. D., Prince, O. A., Rangel-Moreno, J., Thomas, K. A., Scordo, J. M., Torrelles, J. B., Cox, J., Steyn, A. J. C., Zúñiga, J., Kaushal, D. & Khader, S. A., Jun 30 2020, In : Frontiers in immunology. 11, 1325.

    Research output: Contribution to journalArticle

    Open Access
  • Immune correlates of tuberculosis disease and risk translate across species

    Ahmed, M., Thirunavukkarasu, S., Rosa, B. A., Thomas, K. A., Das, S., Rangel-Moreno, J., Lu, L., Mehra, S., Mbandi, S. K., Thackray, L. B., Diamond, M. S., Murphy, K. M., Means, T., Martin, J., Kaushal, D., Scriba, T. J., Mitreva, M. & Khader, S. A., Jan 29 2020, In : Science translational medicine. 12, 528, eaay0233.

    Research output: Contribution to journalArticle

  • 1 Scopus citations