Sessions Cole

Park J White, M.D. Professor of Pediatrics, Professor of Cell Biology and Physiology, Executive Vice Chair of the Department of Pediatrics, Executive Vice Chair of the Department of Pediatrics

    • Source: Scopus
    1976 …2021

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    Research interests

    Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic linkage, recurrent familial cases, targeted gene ablation in murine lineages, and by racial disparity in risk of neonatal respiratory distress syndrome. Successful fetal-neonatal pulmonary transition requires production of the pulmonary surfactant, a phospholipid-protein film that lines alveoli and maintains alveolar patency at end expiration. Our goal is to understand the genetic mechanisms that disrupt pulmonary surfactant metabolism and cause neonatal respiratory distress syndrome.

    Areas of Clinical Interest

    Inherited lung diseases of infancy, surfactant protein-B deficiency, newborn immunity, newborn infections, complement biosynthesis

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