Personal profile

Research interests

Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic linkage, recurrent familial cases, targeted gene ablation in murine lineages, and by racial disparity in risk of neonatal respiratory distress syndrome. Successful fetal-neonatal pulmonary transition requires production of the pulmonary surfactant, a phospholipid-protein film that lines alveoli and maintains alveolar patency at end expiration. Our goal is to understand the genetic mechanisms that disrupt pulmonary surfactant metabolism and cause neonatal respiratory distress syndrome.

Clinical interests

Inherited lung diseases of infancy, surfactant protein-B deficiency, newborn immunity, newborn infections, complement biosynthesis


Dr. Cole has mentored more than 100 trainees from high school students to post-doctoral scientists and junior faculty members.  He is committed to mentoring through listening, problem solving, nurturing, and critical thinking and to an inclusive, supportive, and scientifically rigorous environment.

Available to Mentor:

  • PhD/MSTP Students


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Collaborations and top research areas from the last five years

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