Personal profile
Research interests
We have recently discovered that HIV-1 Integrase protein regulates particle maturation, a role completely independent of its catalytic activity. This involves the binding of integrase to viral RNA molecules, which ensures the encapsidation of viral RNA and IN in the viral core. Remarkably, integrase-RNA interactions can be targeted by a novel class of compounds that are currently in clinical trials. Our goal is to discover novel compounds that directly target integrase-RNA interactions and determine their mechanism of action, which will be of great value in the clinical setting.
Available to Mentor:
- PhD Students
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
SARS-CoV-2 Antivirals Identified from Small Molecule Modulators of Programmed −1 Ribosomal Frameshifting
Swanson Hay, E. G., Maille, M. M., Zafferani, M., Puray-Chavez, M., Xia, M., Luu, T. T. B., Muralidharan, D., Li, M. L., Brewer, G., Kutluay, S. B., Mouzakis, K. D. & Hargrove, A. E., May 8 2026, In: ACS Infectious Diseases. 12, 5, p. 1586-1599 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging
Vuong, H. R., Zhou, Q., Lesko, S. L., Tenneti, K., Davis, K., Scott, S., Guo, M., Boodwa-Ko, D., Eschbach, J. E., Gopal, K., Porter, J. M., Wang, Q., Xia, M., Boateng, A., Wang, Y., Mohammed, S., Lee, N., Telesnitsky, A., Sherer, N. M. & Kutluay, S. B., Apr 7 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 14, e2522851123.Research output: Contribution to journal › Article › peer-review
Open Access -
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models
Puray-Chavez, M., Eschbach, J. E., Xia, M., LaPak, K. M., Zhou, Q., Jasuja, R., Pan, J., Xu, J., Zhou, Z., Mohammed, S., Wang, Q., Lawson, D. Q., Djokic, S., Hou, G., Ding, S., Brody, S. L., Major, M. B., Goldfarb, D. & Kutluay, S. B., Dec 2024, In: Nature communications. 15, 1, 8394.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Scopus citations -
Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels
Zeng, Q., Antia, A., Casorla-Perez, L. A., Puray-Chavez, M., Kutluay, S. B., Ciorba, M. A. & Ding, S., Mar 2024, In: mBio. 15, 3Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs
Whitworth, I. T., Knoener, R. A., Puray-Chavez, M., Halfmann, P., Romero, S., Baddouh, M., Scalf, M., Kawaoka, Y., Kutluay, S. B., Smith, L. M. & Sherer, N. M., Jan 5 2024, In: Journal of Proteome Research. 23, 1, p. 149-160 12 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations